Ankrd49 (ankyrin repeat domain 49) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ankrd49 (ankyrin repeat domain 49) Rattus norvegicus
Analyze
Symbol: Ankrd49
Name: ankyrin repeat domain 49
RGD ID: 1311759
Description: Predicted to be involved in positive regulation of DNA-templated transcription. Orthologous to human ANKRD49 (ankyrin repeat domain 49); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ankyrin repeat domain-containing protein 49; LOC315434; RGD1311759; similar to hypothetical protein FLJ20189
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8819,908,968 - 19,913,656 (-)NCBIGRCr8
mRatBN7.2811,627,512 - 11,632,200 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,627,518 - 11,632,207 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx815,612,322 - 15,617,018 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0813,910,067 - 13,914,763 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0811,885,651 - 11,890,344 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0813,299,556 - 13,304,244 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,299,561 - 13,304,244 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0813,240,202 - 13,244,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,582,729 - 11,587,414 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1811,584,027 - 11,585,732 (-)NCBI
Celera813,097,199 - 13,101,884 (-)NCBICelera
Cytogenetic Map8q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:11162141   PMID:12477932   PMID:16131492  


Genomics

Comparative Map Data
Ankrd49
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8819,908,968 - 19,913,656 (-)NCBIGRCr8
mRatBN7.2811,627,512 - 11,632,200 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,627,518 - 11,632,207 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx815,612,322 - 15,617,018 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0813,910,067 - 13,914,763 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0811,885,651 - 11,890,344 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0813,299,556 - 13,304,244 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,299,561 - 13,304,244 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0813,240,202 - 13,244,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,582,729 - 11,587,414 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1811,584,027 - 11,585,732 (-)NCBI
Celera813,097,199 - 13,101,884 (-)NCBICelera
Cytogenetic Map8q12NCBI
ANKRD49
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381194,493,984 - 94,499,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1194,493,979 - 94,499,578 (+)EnsemblGRCh38hg38GRCh38
GRCh371194,227,150 - 94,232,744 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361193,866,801 - 93,872,392 (+)NCBINCBI36Build 36hg18NCBI36
Celera1191,514,963 - 91,520,554 (+)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1190,292,648 - 90,298,239 (+)NCBIHuRef
CHM1_11194,110,168 - 94,115,759 (+)NCBICHM1_1
T2T-CHM13v2.01194,501,024 - 94,506,618 (+)NCBIT2T-CHM13v2.0
Ankrd49
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,690,916 - 14,695,869 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl914,690,914 - 14,696,152 (-)EnsemblGRCm39 Ensembl
GRCm38914,779,620 - 14,784,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl914,779,618 - 14,784,856 (-)EnsemblGRCm38mm10GRCm38
MGSCv37914,584,642 - 14,587,408 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36914,530,591 - 14,533,357 (-)NCBIMGSCv36mm8
Celera912,060,935 - 12,063,701 (-)NCBICelera
Cytogenetic Map9A2NCBI
cM Map94.33NCBI
ANKRD49
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2995,341,191 - 95,346,823 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11196,432,682 - 96,441,112 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01189,500,796 - 89,506,436 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11192,986,088 - 92,991,713 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,986,224 - 92,991,713 (+)Ensemblpanpan1.1panPan2
ANKRD49
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,443,330 - 6,449,676 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,443,844 - 6,446,591 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,454,014 - 6,460,370 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0216,623,991 - 6,630,353 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl216,623,991 - 6,630,255 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1216,410,819 - 6,417,174 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0216,473,886 - 6,480,248 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0216,522,972 - 6,529,328 (-)NCBIUU_Cfam_GSD_1.0
Ankrd49
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494779,424,965 - 79,430,472 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936674460,456 - 466,410 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936674459,976 - 466,366 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANKRD49
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl926,634,708 - 26,642,512 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1926,634,616 - 26,642,520 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2930,388,480 - 30,396,511 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANKRD49
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,694,327 - 85,700,585 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,694,365 - 85,699,352 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604340,073,785 - 40,080,095 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ankrd49
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473539,153,975 - 39,159,531 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ankrd49
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:294
Count of miRNA genes:208
Interacting mature miRNAs:236
Transcripts:ENSRNOT00000012583
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat

Markers in Region
RH136874  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2811,627,550 - 11,627,748 (+)MAPPERmRatBN7.2
Rnor_6.0813,299,595 - 13,299,792NCBIRnor6.0
Rnor_5.0813,240,241 - 13,240,438UniSTSRnor5.0
RGSC_v3.4811,582,765 - 11,582,962UniSTSRGSC3.4
Celera813,097,235 - 13,097,432UniSTS
RH 3.4 Map8107.4UniSTS
Cytogenetic Map8q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000012583   ⟹   ENSRNOP00000012583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl811,627,518 - 11,632,207 (-)Ensembl
Rnor_6.0 Ensembl813,299,561 - 13,304,244 (-)Ensembl
RefSeq Acc Id: NM_001126283   ⟹   NP_001119755
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,908,971 - 19,913,656 (-)NCBI
mRatBN7.2811,627,515 - 11,632,200 (-)NCBI
Rnor_6.0813,299,559 - 13,304,244 (-)NCBI
Rnor_5.0813,240,202 - 13,244,890 (-)NCBI
RGSC_v3.4811,582,729 - 11,587,414 (-)RGD
Celera813,097,199 - 13,101,884 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242525   ⟹   XP_006242587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,908,968 - 19,913,644 (-)NCBI
mRatBN7.2811,627,512 - 11,632,192 (-)NCBI
Rnor_6.0813,299,556 - 13,304,223 (-)NCBI
Rnor_5.0813,240,202 - 13,244,890 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039081350   ⟹   XP_038937278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,908,968 - 19,913,609 (-)NCBI
mRatBN7.2811,627,512 - 11,632,075 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001119755 (Get FASTA)   NCBI Sequence Viewer  
  XP_006242587 (Get FASTA)   NCBI Sequence Viewer  
  XP_038937278 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI61982 (Get FASTA)   NCBI Sequence Viewer  
  EDL78464 (Get FASTA)   NCBI Sequence Viewer  
  EDL78465 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012583.4
RefSeq Acc Id: NP_001119755   ⟸   NM_001126283
- UniProtKB: B1WC29 (UniProtKB/TrEMBL),   A6JNA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242587   ⟸   XM_006242525
- Peptide Label: isoform X1
- UniProtKB: B1WC29 (UniProtKB/TrEMBL),   A6JNA1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012583   ⟸   ENSRNOT00000012583
RefSeq Acc Id: XP_038937278   ⟸   XM_039081350
- Peptide Label: isoform X1
- UniProtKB: B1WC29 (UniProtKB/TrEMBL),   A6JNA1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WC29-F1-model_v2 AlphaFold B1WC29 1-239 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695748
Promoter ID:EPDNEW_R6272
Type:multiple initiation site
Name:Ankrd49_1
Description:ankyrin repeat domain 49
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0813,304,237 - 13,304,297EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311759 AgrOrtholog
BioCyc Gene G2FUF-31682 BioCyc
Ensembl Genes ENSRNOG00000009233 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012583.5 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9030206 IMAGE-MGC_LOAD
InterPro Ank_repeat_dom-contain_49 UniProtKB/TrEMBL
  Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
KEGG Report rno:315434 UniProtKB/TrEMBL
MGC_CLONE MGC:187797 IMAGE-MGC_LOAD
NCBI Gene 315434 ENTREZGENE
PANTHER ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 49 UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
PhenoGen Ankrd49 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009233 RatGTEx
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
UniProt A6JNA1 ENTREZGENE, UniProtKB/TrEMBL
  B1WC29 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ankrd49  ankyrin repeat domain 49   Ankrd49_predicted  ankyrin repeat domain 49 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ankrd49_predicted  ankyrin repeat domain 49 (predicted)  RGD1311759_predicted  similar to hypothetical protein FLJ20189 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1311759_predicted  similar to hypothetical protein FLJ20189 (predicted)  LOC315434_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC315434_predicted  similar to hypothetical protein FLJ20189 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL