Paqr3 (progestin and adipoQ receptor family member 3) - Rat Genome Database

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Gene: Paqr3 (progestin and adipoQ receptor family member 3) Rattus norvegicus
Analyze
Symbol: Paqr3
Name: progestin and adipoQ receptor family member 3
RGD ID: 1310426
Description: Predicted to enable signaling receptor activity. Predicted to act upstream of or within negative regulation of neuron projection development; negative regulation of protein phosphorylation; and protein localization to Golgi apparatus. Predicted to be located in Golgi apparatus. Orthologous to human PAQR3 (progestin and adipoQ receptor family member 3); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC305203; progestin and adipoQ receptor family member III
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81412,766,539 - 12,796,461 (+)NCBIGRCr8
mRatBN7.21412,462,568 - 12,484,999 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1412,462,563 - 12,479,994 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1412,430,368 - 12,447,743 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01413,730,208 - 13,747,583 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01412,446,315 - 12,463,624 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01414,107,513 - 14,129,780 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1414,107,580 - 14,124,828 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01414,051,394 - 14,073,580 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41413,915,443 - 13,932,809 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11413,915,442 - 13,932,807 (+)NCBI
Celera1412,524,152 - 12,541,469 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. Tang YT, etal., J Mol Evol. 2005 Sep;61(3):372-80. Epub 2005 Jul 21.
Additional References at PubMed
PMID:12477932   PMID:17724343   PMID:34461141  


Genomics

Comparative Map Data
Paqr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81412,766,539 - 12,796,461 (+)NCBIGRCr8
mRatBN7.21412,462,568 - 12,484,999 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1412,462,563 - 12,479,994 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1412,430,368 - 12,447,743 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01413,730,208 - 13,747,583 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01412,446,315 - 12,463,624 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01414,107,513 - 14,129,780 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1414,107,580 - 14,124,828 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01414,051,394 - 14,073,580 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41413,915,443 - 13,932,809 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11413,915,442 - 13,932,807 (+)NCBI
Celera1412,524,152 - 12,541,469 (+)NCBICelera
Cytogenetic Map14p22NCBI
PAQR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38478,887,076 - 78,939,438 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl478,887,127 - 78,939,438 (-)EnsemblGRCh38hg38GRCh38
GRCh37479,833,032 - 79,860,592 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36480,058,118 - 80,079,606 (-)NCBINCBI36Build 36hg18NCBI36
Build 34480,196,273 - 80,217,736NCBI
Celera477,134,736 - 77,156,218 (-)NCBICelera
Cytogenetic Map4q21.21NCBI
HuRef475,584,922 - 75,606,407 (-)NCBIHuRef
CHM1_1479,815,596 - 79,837,073 (-)NCBICHM1_1
T2T-CHM13v2.0482,222,838 - 82,275,056 (-)NCBIT2T-CHM13v2.0
Paqr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39597,229,223 - 97,259,608 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl597,230,188 - 97,259,455 (-)EnsemblGRCm39 Ensembl
GRCm38597,081,364 - 97,111,749 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl597,082,329 - 97,111,596 (-)EnsemblGRCm38mm10GRCm38
MGSCv37597,511,348 - 97,540,615 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36597,322,631 - 97,351,898 (-)NCBIMGSCv36mm8
Celera594,418,839 - 94,448,197 (-)NCBICelera
Cytogenetic Map5E3NCBI
cM Map547.29NCBI
Paqr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554333,321,625 - 3,350,588 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554333,323,426 - 3,350,358 (-)NCBIChiLan1.0ChiLan1.0
PAQR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2351,123,276 - 51,144,710 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1451,312,480 - 51,333,914 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0445,255,403 - 45,279,319 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1451,102,305 - 51,126,259 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl451,102,305 - 51,123,506 (+)Ensemblpanpan1.1panPan2
PAQR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1323,292,034 - 3,316,914 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl323,288,645 - 3,316,965 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3238,564,201 - 38,592,983 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0323,313,961 - 3,342,769 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl323,320,252 - 3,342,882 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1323,357,006 - 3,379,920 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0323,249,518 - 3,278,120 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03236,891,795 - 36,920,580 (+)NCBIUU_Cfam_GSD_1.0
Paqr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052858,986,750 - 9,063,357 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366762,497,728 - 2,520,499 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366762,497,219 - 2,520,493 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAQR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8138,646,625 - 138,669,115 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18138,646,626 - 138,670,166 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28147,790,069 - 147,815,994 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAQR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1727,358,443 - 27,385,612 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl727,367,059 - 27,385,568 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660375,742,288 - 5,769,928 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Paqr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475712,138,681 - 12,159,661 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475712,140,041 - 12,303,568 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Paqr3
113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:495
Count of miRNA genes:232
Interacting mature miRNAs:293
Transcripts:ENSRNOT00000032130
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000032130   ⟹   ENSRNOP00000037290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1412,462,630 - 12,479,994 (+)Ensembl
Rnor_6.0 Ensembl1414,107,580 - 14,124,828 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105516   ⟹   ENSRNOP00000083560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1412,462,563 - 12,465,424 (+)Ensembl
RefSeq Acc Id: NM_001012033   ⟹   NP_001012033
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81412,766,605 - 12,783,971 (+)NCBI
mRatBN7.21412,462,630 - 12,479,996 (+)NCBI
Rnor_6.01414,107,580 - 14,124,830 (+)NCBI
Rnor_5.01414,051,394 - 14,073,580 (+)NCBI
RGSC_v3.41413,915,443 - 13,932,809 (+)RGD
Celera1412,524,152 - 12,541,469 (+)RGD
Sequence:
RefSeq Acc Id: XM_017599170   ⟹   XP_017454659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81412,766,539 - 12,783,976 (+)NCBI
mRatBN7.21412,462,568 - 12,480,001 (+)NCBI
Rnor_6.01414,107,513 - 14,126,464 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599171   ⟹   XP_017454660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81412,766,539 - 12,796,461 (+)NCBI
mRatBN7.21412,462,568 - 12,484,999 (+)NCBI
Rnor_6.01414,107,513 - 14,129,780 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091840   ⟹   XP_038947768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81412,766,768 - 12,785,878 (+)NCBI
mRatBN7.21412,462,796 - 12,481,630 (+)NCBI
RefSeq Acc Id: XM_039091841   ⟹   XP_038947769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81412,766,793 - 12,785,878 (+)NCBI
mRatBN7.21412,462,793 - 12,481,630 (+)NCBI
RefSeq Acc Id: XR_010057364
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81412,766,539 - 12,796,461 (+)NCBI
RefSeq Acc Id: NP_001012033   ⟸   NM_001012033
- UniProtKB: Q6AXP7 (UniProtKB/TrEMBL),   A6K658 (UniProtKB/TrEMBL),   A6K659 (UniProtKB/TrEMBL),   F7ELC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454660   ⟸   XM_017599171
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017454659   ⟸   XM_017599170
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000037290   ⟸   ENSRNOT00000032130
RefSeq Acc Id: XP_038947769   ⟸   XM_039091841
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038947768   ⟸   XM_039091840
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000083560   ⟸   ENSRNOT00000105516

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXP7-F1-model_v2 AlphaFold Q6AXP7 1-311 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699201
Promoter ID:EPDNEW_R9726
Type:initiation region
Name:Paqr3_1
Description:progestin and adipoQ receptor family member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01414,107,545 - 14,107,605EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310426 AgrOrtholog
BioCyc Gene G2FUF-16344 BioCyc
Ensembl Genes ENSRNOG00000002035 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032130.5 UniProtKB/TrEMBL
  ENSRNOT00000105516.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7113653 IMAGE-MGC_LOAD
InterPro HlyIII_related UniProtKB/TrEMBL
KEGG Report rno:305203 UniProtKB/TrEMBL
MGC_CLONE MGC:94959 IMAGE-MGC_LOAD
NCBI Gene 305203 ENTREZGENE
PANTHER HlyIII_related UniProtKB/TrEMBL
  PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3 UniProtKB/TrEMBL
Pfam HlyIII UniProtKB/TrEMBL
PhenoGen Paqr3 PhenoGen
RatGTEx ENSRNOG00000002035 RatGTEx
UniProt A0A8I6G974_RAT UniProtKB/TrEMBL
  A6K658 ENTREZGENE, UniProtKB/TrEMBL
  A6K659 ENTREZGENE, UniProtKB/TrEMBL
  F7ELC3 ENTREZGENE, UniProtKB/TrEMBL
  Q6AXP7 ENTREZGENE
UniProt Secondary Q6AXP7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Paqr3  progestin and adipoQ receptor family member 3  Paqr3  progestin and adipoQ receptor family member III  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Paqr3  progestin and adipoQ receptor family member III  Paqr3_predicted  progestin and adipoQ receptor family member III (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Paqr3_predicted  progestin and adipoQ receptor family member III (predicted)      Symbol and Name status set to approved 70820 APPROVED