Maml1 (mastermind-like transcriptional coactivator 1) - Rat Genome Database

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Gene: Maml1 (mastermind-like transcriptional coactivator 1) Rattus norvegicus
Analyze
Symbol: Maml1
Name: mastermind-like transcriptional coactivator 1
RGD ID: 1308631
Description: Predicted to enable peptide antigen binding activity; protein kinase binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including atrioventricular node cell development; positive regulation of myotube differentiation; and positive regulation of transcription of Notch receptor target. Predicted to act upstream of or within Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of MAML1-RBP-Jkappa- ICN1 complex. Predicted to be active in nucleoplasm. Orthologous to human MAML1 (mastermind like transcriptional coactivator 1); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC303101; mastermind like 1; mastermind like 1 (Drosophila); mastermind-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,089,715 - 35,124,100 (-)NCBIGRCr8
mRatBN7.21034,588,639 - 34,623,024 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,588,646 - 34,623,338 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,259,884 - 39,294,285 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,799,136 - 7,833,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,253,556 - 34,287,955 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,765,196 - 35,801,375 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,765,719 - 35,800,120 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,526,970 - 35,561,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,814,839 - 35,850,122 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,818,052 - 35,851,152 (-)NCBI
Celera1033,936,867 - 33,971,456 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Wang SY, etal., Neuroscience. 2015 Aug 20;301:276-88. doi: 10.1016/j.neuroscience.2015.06.002. Epub 2015 Jun 8.
Additional References at PubMed
PMID:9874765   PMID:11101851   PMID:15019995   PMID:15546612   PMID:16510869   PMID:17317671   PMID:21266778   PMID:23160044  


Genomics

Comparative Map Data
Maml1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,089,715 - 35,124,100 (-)NCBIGRCr8
mRatBN7.21034,588,639 - 34,623,024 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,588,646 - 34,623,338 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,259,884 - 39,294,285 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,799,136 - 7,833,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,253,556 - 34,287,955 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,765,196 - 35,801,375 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,765,719 - 35,800,120 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,526,970 - 35,561,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,814,839 - 35,850,122 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,818,052 - 35,851,152 (-)NCBI
Celera1033,936,867 - 33,971,456 (-)NCBICelera
Cytogenetic Map10q22NCBI
MAML1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385179,732,822 - 179,777,283 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5179,732,822 - 179,777,283 (+)EnsemblGRCh38hg38GRCh38
GRCh375179,159,823 - 179,204,284 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,092,457 - 179,136,890 (+)NCBINCBI36Build 36hg18NCBI36
Build 345179,092,456 - 179,136,887NCBI
Celera5174,784,899 - 174,829,445 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,886,041 - 173,930,435 (+)NCBIHuRef
CHM1_15178,592,272 - 178,636,696 (+)NCBICHM1_1
T2T-CHM13v2.05180,288,007 - 180,332,482 (+)NCBIT2T-CHM13v2.0
Maml1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,146,461 - 50,183,163 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,146,461 - 50,183,138 (-)EnsemblGRCm39 Ensembl
GRCm381150,255,634 - 50,293,131 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,255,634 - 50,292,311 (-)EnsemblGRCm38mm10GRCm38
MGSCv371150,069,136 - 50,105,838 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,099,061 - 50,110,291 (-)NCBIMGSCv36mm8
Celera1154,816,231 - 54,852,945 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.42NCBI
Maml1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955408804,535 - 813,475 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955408802,277 - 850,218 (-)NCBIChiLan1.0ChiLan1.0
MAML1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24174,675,398 - 174,719,867 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,814,949 - 172,861,947 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,886,694 - 174,931,153 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15182,203,371 - 182,242,296 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5182,230,351 - 182,242,296 (+)Ensemblpanpan1.1panPan2
MAML1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,915,622 - 1,927,598 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,918,133 - 1,963,836 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha112,038,998 - 2,087,221 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0111,890,184 - 1,938,415 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl111,890,898 - 1,938,376 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1111,861,654 - 1,909,956 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,940,584 - 1,988,788 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,181,090 - 2,229,297 (-)NCBIUU_Cfam_GSD_1.0
Maml1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,797,158 - 119,840,812 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367391,006,705 - 1,050,394 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367391,006,273 - 1,051,338 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAML1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,818,411 - 78,876,615 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,818,658 - 78,876,633 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2280,385,037 - 80,443,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAML1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12381,456,537 - 81,508,893 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2381,496,033 - 81,506,497 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607512,831,231 - 12,885,701 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Maml1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473342,618,127 - 42,663,827 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473342,618,105 - 42,663,262 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Maml1
135 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:667
Count of miRNA genes:296
Interacting mature miRNAs:386
Transcripts:ENSRNOT00000004361
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
RH131159  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21034,623,866 - 34,624,052 (+)MAPPERmRatBN7.2
Rnor_6.01035,800,944 - 35,801,129NCBIRnor6.0
Rnor_5.01035,562,610 - 35,562,795UniSTSRnor5.0
RGSC_v3.41035,850,946 - 35,851,131UniSTSRGSC3.4
Celera1033,972,280 - 33,972,465UniSTS
RH 3.4 Map10347.4UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004361   ⟹   ENSRNOP00000004361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,588,646 - 34,623,338 (-)Ensembl
Rnor_6.0 Ensembl1035,765,719 - 35,800,120 (-)Ensembl
RefSeq Acc Id: NM_001401556   ⟹   NP_001388485
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,089,715 - 35,124,100 (-)NCBI
mRatBN7.21034,588,639 - 34,623,024 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001388485 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM04267 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004361.6
Ensembl Acc Id: ENSRNOP00000004361   ⟸   ENSRNOT00000004361
RefSeq Acc Id: NP_001388485   ⟸   NM_001401556
- UniProtKB: D4A930 (UniProtKB/TrEMBL)
Protein Domains
Mastermind-like 1/3 transactivation   Neurogenic mastermind-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A930-F1-model_v2 AlphaFold D4A930 1-784 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697153
Promoter ID:EPDNEW_R7677
Type:single initiation site
Name:Maml1_1
Description:mastermind-like transcriptional coactivator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01035,800,118 - 35,800,178EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308631 AgrOrtholog
BioCyc Gene G2FUF-25244 BioCyc
Ensembl Genes ENSRNOG00000003268 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004361.7 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.970 UniProtKB/TrEMBL
InterPro MAML1-3 UniProtKB/TrEMBL
  MAML1_3_TAD2 UniProtKB/TrEMBL
  MAML_N_sf UniProtKB/TrEMBL
  Mastermind-like_N UniProtKB/TrEMBL
NCBI Gene 303101 ENTREZGENE
PANTHER MASTERMIND-LIKE PROTEIN 1 UniProtKB/TrEMBL
  PTHR15692 UniProtKB/TrEMBL
Pfam MamL-1 UniProtKB/TrEMBL
  MAML1_3_TAD2 UniProtKB/TrEMBL
PhenoGen Maml1 PhenoGen
RatGTEx ENSRNOG00000003268 RatGTEx
SMART MamL-1 UniProtKB/TrEMBL
UniProt A6HE12_RAT UniProtKB/TrEMBL
  D4A930 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-13 Maml1  mastermind-like transcriptional coactivator 1  Maml1  mastermind like 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Maml1  mastermind like 1 (Drosophila)   Maml1_predicted  mastermind like 1 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Maml1_predicted  mastermind like 1 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED