Syne2 (spectrin repeat containing nuclear envelope protein 2) - Rat Genome Database

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Gene: Syne2 (spectrin repeat containing nuclear envelope protein 2) Rattus norvegicus
Analyze
Symbol: Syne2
Name: spectrin repeat containing nuclear envelope protein 2
RGD ID: 1305248
Description: Predicted to enable actin binding activity and cytoskeleton-nuclear membrane anchor activity. Predicted to be involved in several processes, including centrosome localization; nuclear migration; and regulation of cilium assembly. Predicted to be located in several cellular components, including cell projection membrane; focal adhesion; and nucleus. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Used to study cryptorchidism. Human ortholog(s) of this gene implicated in autosomal dominant Emery-Dreifuss muscular dystrophy 5. Orthologous to human SYNE2 (spectrin repeat containing nuclear envelope protein 2); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cefaloridine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07064873.1; LOC102551447; LOC299151; LOC366669; nesprin 2 long isoform; nesprin-2; nesprin-2-like; RGD1305248; similar to mKIAA1011 protein; similar to nesprin-2; spectrin repeat containing, nuclear envelope 2; synaptic nuclear envelope 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,272,729 - 100,586,364 (+)NCBIGRCr8
mRatBN7.2694,537,088 - 94,848,085 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl694,537,088 - 94,848,064 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0698,884,269 - 99,153,551 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl698,844,926 - 99,153,551 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.06108,300,643 - 108,565,625 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,457,147 - 98,601,686 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1698,460,902 - 98,605,226 (+)NCBI
Celera693,001,776 - 93,273,770 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7beta-aminocephalosporanic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
ammonium hexachloroplatinate  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clotrimazole  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
diallyl trisulfide  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epichlorohydrin  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
glafenine  (EXP)
glycidol  (EXP)
hexamethylene diisocyanate  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Polygenic inheritance of cryptorchidism susceptibility in the LE/orl rat. Barthold JS, etal., Mol Hum Reprod. 2016 Jan;22(1):18-34. doi: 10.1093/molehr/gav060. Epub 2015 Oct 26.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12118075   PMID:12477932   PMID:15671068   PMID:18396275   PMID:18477613   PMID:18570454   PMID:19596800   PMID:19874786   PMID:20457914   PMID:20724637   PMID:22349700   PMID:25721888  
PMID:26506308  


Genomics

Comparative Map Data
Syne2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,272,729 - 100,586,364 (+)NCBIGRCr8
mRatBN7.2694,537,088 - 94,848,085 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl694,537,088 - 94,848,064 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0698,884,269 - 99,153,551 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl698,844,926 - 99,153,551 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.06108,300,643 - 108,565,625 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,457,147 - 98,601,686 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1698,460,902 - 98,605,226 (+)NCBI
Celera693,001,776 - 93,273,770 (+)NCBICelera
Cytogenetic Map6q24NCBI
SYNE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381463,761,596 - 64,226,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1463,761,899 - 64,226,433 (+)EnsemblGRCh38hg38GRCh38
GRCh371464,319,722 - 64,693,167 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361463,389,436 - 63,762,920 (+)NCBINCBI36Build 36hg18NCBI36
Build 341463,612,085 - 63,762,903NCBI
Celera1444,377,022 - 44,750,869 (+)NCBICelera
Cytogenetic Map14q23.2NCBI
HuRef1444,548,587 - 44,865,749 (+)NCBIHuRef
CHM1_11464,258,594 - 64,632,989 (+)NCBICHM1_1
T2T-CHM13v2.01457,969,282 - 58,434,164 (+)NCBIT2T-CHM13v2.0
Syne2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391275,865,092 - 76,157,702 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1275,864,908 - 76,157,700 (+)EnsemblGRCm39 Ensembl
GRCm381275,818,318 - 76,110,928 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1275,818,134 - 76,110,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv371276,919,305 - 77,211,915 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361276,772,909 - 77,029,768 (+)NCBIMGSCv36mm8
Celera1276,923,010 - 77,205,661 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.11NCBI
Syne2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554665,646,516 - 5,926,382 (-)NCBIChiLan1.0ChiLan1.0
SYNE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21564,969,228 - 65,338,128 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11464,185,749 - 64,554,042 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01444,438,851 - 44,807,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11462,694,928 - 63,064,136 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1462,751,560 - 63,064,136 (+)Ensemblpanpan1.1panPan2
SYNE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1838,373,900 - 38,643,544 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl838,373,964 - 38,643,240 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha838,066,748 - 38,335,928 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0838,601,180 - 38,866,632 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl838,550,295 - 38,866,628 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1838,217,742 - 38,486,813 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0838,289,976 - 38,558,948 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0838,650,638 - 38,919,080 (+)NCBIUU_Cfam_GSD_1.0
Syne2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864066,242,282 - 66,512,354 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364957,658,250 - 7,949,417 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYNE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1193,911,965 - 194,264,354 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11193,909,563 - 194,352,550 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,795,839 - 216,243,192 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SYNE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,054,609 - 41,443,067 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,054,621 - 41,443,436 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605329,245,733 - 29,619,251 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Syne2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473436,832,490 - 37,167,438 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Syne2
1509 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat

Markers in Region
D6Rat72  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2694,710,382 - 94,710,591 (+)MAPPERmRatBN7.2
Rnor_6.0699,015,382 - 99,015,590NCBIRnor6.0
Rnor_5.06108,431,344 - 108,431,552UniSTSRnor5.0
RGSC_v3.4698,591,094 - 98,591,303RGDRGSC3.4
RGSC_v3.4698,591,095 - 98,591,303UniSTSRGSC3.4
RGSC_v3.1698,594,550 - 98,594,759RGD
Celera693,135,618 - 93,135,828UniSTS
FHH x ACI Map668.04RGD
FHH x ACI Map668.04UniSTS
Cytogenetic Map6q24UniSTS
BI301410  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2694,743,043 - 94,743,197 (+)MAPPERmRatBN7.2
Rnor_6.0699,048,675 - 99,048,828NCBIRnor6.0
Rnor_5.06108,462,531 - 108,462,684UniSTSRnor5.0
Celera693,169,251 - 93,169,404UniSTS
RH 3.4 Map6670.2UniSTS
Cytogenetic Map6q24UniSTS
BF390456  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0699,143,452 - 99,143,639NCBIRnor6.0
Rnor_5.06108,555,526 - 108,555,713UniSTSRnor5.0
RH 3.4 Map6671.1UniSTS
Cytogenetic Map6q24UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC098809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK681779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000007070   ⟹   ENSRNOP00000079593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl694,537,088 - 94,848,064 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078463   ⟹   ENSRNOP00000079026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl694,817,610 - 94,848,064 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092100   ⟹   ENSRNOP00000097901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl694,537,088 - 94,848,064 (+)Ensembl
RefSeq Acc Id: NM_001427326   ⟹   NP_001414255
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,272,729 - 100,583,743 (+)NCBI
RefSeq Acc Id: XM_039113258   ⟹   XP_038969186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,272,768 - 100,586,364 (+)NCBI
mRatBN7.2694,537,122 - 94,848,084 (+)NCBI
RefSeq Acc Id: XM_039113259   ⟹   XP_038969187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,312,487 - 100,586,364 (+)NCBI
mRatBN7.2694,576,954 - 94,848,085 (+)NCBI
RefSeq Acc Id: XM_039113260   ⟹   XP_038969188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,312,484 - 100,586,364 (+)NCBI
mRatBN7.2694,576,386 - 94,848,085 (+)NCBI
RefSeq Acc Id: XM_039113261   ⟹   XP_038969189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,272,768 - 100,586,364 (+)NCBI
mRatBN7.2694,537,122 - 94,848,084 (+)NCBI
RefSeq Acc Id: XM_039113262   ⟹   XP_038969190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,272,768 - 100,586,364 (+)NCBI
mRatBN7.2694,537,122 - 94,848,084 (+)NCBI
RefSeq Acc Id: XM_039113263   ⟹   XP_038969191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,272,768 - 100,586,364 (+)NCBI
mRatBN7.2694,537,122 - 94,848,084 (+)NCBI
RefSeq Acc Id: XM_039113264   ⟹   XP_038969192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,272,768 - 100,586,364 (+)NCBI
mRatBN7.2694,537,122 - 94,848,084 (+)NCBI
RefSeq Acc Id: XM_039113268   ⟹   XP_038969196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,272,768 - 100,586,364 (+)NCBI
mRatBN7.2694,537,122 - 94,848,084 (+)NCBI
RefSeq Acc Id: XM_039113269   ⟹   XP_038969197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,272,768 - 100,578,828 (+)NCBI
mRatBN7.2694,537,122 - 94,843,132 (+)NCBI
RefSeq Acc Id: XM_039113270   ⟹   XP_038969198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,425,331 - 100,586,364 (+)NCBI
mRatBN7.2694,688,932 - 94,848,085 (+)NCBI
RefSeq Acc Id: XM_063262183   ⟹   XP_063118253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,272,768 - 100,586,364 (+)NCBI
RefSeq Acc Id: XM_063262184   ⟹   XP_063118254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,272,768 - 100,586,364 (+)NCBI
RefSeq Acc Id: XM_063262185   ⟹   XP_063118255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,549,785 - 100,586,364 (+)NCBI
RefSeq Acc Id: XP_038969186   ⟸   XM_039113258
- Peptide Label: isoform X1
- UniProtKB: A0A5P8DHK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969192   ⟸   XM_039113264
- Peptide Label: isoform X6
- UniProtKB: A0A5P8DHK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969191   ⟸   XM_039113263
- Peptide Label: isoform X5
- UniProtKB: A0A5P8DHK3 (UniProtKB/TrEMBL),   A0A8I5ZNW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969196   ⟸   XM_039113268
- Peptide Label: isoform X8
- UniProtKB: A0A5P8DHK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969189   ⟸   XM_039113261
- Peptide Label: isoform X2
- UniProtKB: A0A5P8DHK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969190   ⟸   XM_039113262
- Peptide Label: isoform X3
- UniProtKB: A0A5P8DHK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969197   ⟸   XM_039113269
- Peptide Label: isoform X9
- UniProtKB: A0A5P8DHK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969188   ⟸   XM_039113260
- Peptide Label: isoform X1
- UniProtKB: A0A5P8DHK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969187   ⟸   XM_039113259
- Peptide Label: isoform X1
- UniProtKB: A0A5P8DHK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969198   ⟸   XM_039113270
- Peptide Label: isoform X10
RefSeq Acc Id: ENSRNOP00000079593   ⟸   ENSRNOT00000007070
RefSeq Acc Id: ENSRNOP00000079026   ⟸   ENSRNOT00000078463
RefSeq Acc Id: ENSRNOP00000097901   ⟸   ENSRNOT00000092100
RefSeq Acc Id: NP_001414255   ⟸   NM_001427326
- UniProtKB: A0A5P8DHK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118254   ⟸   XM_063262184
- Peptide Label: isoform X7
- UniProtKB: A0A5P8DHK3 (UniProtKB/TrEMBL),   A0A8I6AWY4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118253   ⟸   XM_063262183
- Peptide Label: isoform X4
- UniProtKB: A0A5P8DHK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118255   ⟸   XM_063262185
- Peptide Label: isoform X11
- UniProtKB: A0A8I5ZM90 (UniProtKB/TrEMBL)
Protein Domains
Calponin-homology (CH)   KASH

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305248 AgrOrtholog
BioCyc Gene G2FUF-37072 BioCyc
Ensembl Genes ENSRNOG00000005323 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007070.9 UniProtKB/TrEMBL
  ENSRNOT00000078463.2 UniProtKB/TrEMBL
  ENSRNOT00000092100.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  Anc-1/SYNE1/2-like UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  KASH UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
NCBI Gene Syne2 ENTREZGENE
PANTHER SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2 UniProtKB/TrEMBL
  SPECTRIN REPEAT-CONTAINING NUCLEAR ENVELOPE PROTEIN 2 UniProtKB/TrEMBL
Pfam KASH UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PhenoGen Syne2 PhenoGen
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  KASH UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005323 RatGTEx
SMART KASH UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP Spectrin repeat UniProtKB/TrEMBL
  SSF47576 UniProtKB/TrEMBL
UniProt A0A5P8DHK3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZM90 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNW6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AWY4 ENTREZGENE, UniProtKB/TrEMBL
  A6HC94_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Syne2  spectrin repeat containing nuclear envelope protein 2  AABR07064873.1    Data merged from RGD:15003291 737654 PROVISIONAL
2021-09-02 AABR07064873.1    Syne2  spectrin repeat containing nuclear envelope protein 2  Symbol and/or name change 19259462 PROVISIONAL
2021-08-09 Syne2  spectrin repeat containing nuclear envelope protein 2  AABR07064873.1    Symbol and/or name change 19259462 PROVISIONAL
2021-03-09 Syne2  spectrin repeat containing nuclear envelope protein 2  LOC102551447  nesprin-2-like  Data merged from RGD:7625884 737654 PROVISIONAL
2019-11-08 AABR07064873.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2016-05-05 Syne2  spectrin repeat containing nuclear envelope protein 2  Syne2  spectrin repeat containing, nuclear envelope 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102551447  nesprin-2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-11-27 Syne2  spectrin repeat containing, nuclear envelope 2  LOC366669  similar to mKIAA1011 protein  Data merged from RGD:1564631 737654 APPROVED
2008-11-17 Syne2  spectrin repeat containing, nuclear envelope 2  Syne2  synaptic nuclear envelope 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Syne2  synaptic nuclear envelope 2  RGD1305248_predicted  similar to nesprin-2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC366669  similar to mKIAA1011 protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1305248_predicted  similar to nesprin-2 (predicted)  LOC299151_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC299151_predicted  similar to nesprin-2 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL