Nppa (natriuretic peptide A) - Rat Genome Database

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Gene: Nppa (natriuretic peptide A) Ictidomys tridecemlineatus
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Symbol: Nppa
Name: natriuretic peptide A
RGD ID: 12453412
Description: ENCODES a protein that exhibits hormone activity (ortholog); hormone receptor binding (ortholog); neuropeptide hormone activity (ortholog); INVOLVED IN cardiac muscle hypertrophy in response to stress (ortholog); cell growth involved in cardiac muscle cell development (ortholog); cellular response to angiotensin (ortholog); PARTICIPATES IN atrial natriuretic peptide signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adenocarcinoma (ortholog); FOUND IN brush border (ortholog); cytoplasm (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: natriuretic peptides A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,846,575 - 34,848,291 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936474671,362 - 673,610 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
aortic valve insufficiency  (ISO)
atrial standstill 1  (ISO)
atrial standstill 2  (ISO)
brain ischemia  (ISO)
Cardiomegaly  (ISO)
chronic kidney disease  (ISO)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (ISO)
coronary artery disease  (ISO)
coronary stenosis  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diastolic heart failure  (ISO)
dilated cardiomyopathy  (ISO)
Experimental Diabetes Mellitus  (ISO)
Familial Atrial Fibrillation 6  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
heart disease  (ISO)
Hypercapnia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypotension  (ISO)
Hypoxia  (ISO)
intrinsic cardiomyopathy  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
Lung Neoplasms  (ISO)
melanoma  (ISO)
Metabolic Side Effects of Drugs and Substances  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
nephrosis  (ISO)
obesity  (ISO)
Pain  (ISO)
patent ductus arteriosus  (ISO)
peritonitis  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
renal hypertension  (ISO)
Right Ventricular Hypertrophy  (ISO)
Skin Neoplasms  (ISO)
small cell carcinoma  (ISO)
stroke  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
Urination Disorders  (ISO)
Ventricular Remodeling  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle hypertrophy in response to stress  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cellular response to angiotensin  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to mechanical stimulus  (ISO)
cGMP biosynthetic process  (ISO)
cGMP metabolic process  (ISO)
female pregnancy  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of collecting lymphatic vessel constriction  (ISO)
negative regulation of epidermal growth factor receptor signaling pathway  (ISO)
negative regulation of JUN kinase activity  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
neuropeptide signaling pathway  (ISO)
positive regulation of cardiac muscle contraction  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of potassium ion export across plasma membrane  (ISO)
protein folding  (ISO)
receptor guanylyl cyclase signaling pathway  (ISO)
regulation of atrial cardiac muscle cell membrane repolarization  (ISO)
regulation of blood pressure  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
response to 3-methylcholanthrene  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
signal transduction  (IEA)
sodium ion export across plasma membrane  (ISO)
synaptic signaling via neuropeptide  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:25679215   PMID:30032202  


Genomics

Comparative Map Data
Nppa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,846,575 - 34,848,291 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936474671,362 - 673,610 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,845,709 - 11,847,783 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,845,709 - 11,848,345 (-)Ensemblhg38GRCh38
GRCh37111,905,766 - 11,907,840 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,828,363 - 11,830,422 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34111,840,041 - 11,842,101NCBI
Celera111,019,389 - 11,021,472 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,060,823 - 11,062,905 (-)NCBIHuRef
CHM1_1111,893,660 - 11,895,736 (-)NCBICHM1_1
T2T-CHM13v2.0111,389,795 - 11,391,868 (-)NCBIT2T-CHM13v2.0
Nppa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,085,179 - 148,086,531 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,085,179 - 148,086,536 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384148,000,722 - 148,002,074 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,000,722 - 148,002,079 (+)Ensemblmm10GRCm38
MGSCv374147,374,855 - 147,376,176 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364146,844,546 - 146,845,867 (+)NCBIMGSCv36mm8
Celera4150,267,117 - 150,268,440 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.66NCBI
Nppa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,712,184 - 163,713,493 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5163,712,184 - 163,713,493 (+)EnsemblGRCr8
mRatBN7.25158,429,042 - 158,430,351 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,429,042 - 158,430,351 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5161,145,793 - 161,147,102 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,973,730 - 162,975,039 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,930,077 - 162,931,386 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5163,291,824 - 163,293,133 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive5165,304,845 - 165,306,154 (+)NCBILyon_Normotensive
Lyon_Hypertensive5164,480,442 - 164,481,751 (+)NCBILyon_Hypertensive
F344_StmMcwi5158,024,844 - 158,026,153 (+)NCBIF344_StmMcwi
Rnor_6.05164,808,407 - 164,809,716 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,808,323 - 164,809,705 (+)Ensemblrn6Rnor6.0
Rnor_5.05168,466,309 - 168,467,618 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45165,074,518 - 165,075,827 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5156,710,885 - 156,712,194 (+)NCBICelera
RGSC_v3.15165,084,713 - 165,086,000 (+)NCBI
RH 3.4 Map51106.6RGD
Cytogenetic Map5q36NCBI
Nppa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,060,735 - 2,063,003 (+)Ensembl
ChiLan1.0NW_0049554862,061,196 - 2,062,805 (+)NCBIChiLan1.0ChiLan1.0
NPPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,375,951 - 216,382,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,021,064 - 215,023,807 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,608,025 - 10,610,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,825,072 - 11,827,452 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,825,072 - 11,827,373 (-)EnsemblpanPan2panpan1.1
NPPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,406,317 - 84,408,115 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,396,073 - 84,408,385 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha280,939,561 - 80,941,359 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0285,071,241 - 85,073,039 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,060,271 - 85,073,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,819,847 - 81,821,645 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,819,771 - 82,821,568 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,882,545 - 83,884,343 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
NPPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,918,845 - 71,921,405 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1671,919,557 - 71,921,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,829,057 - 65,830,990 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,942,412 - 119,946,211 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,944,532 - 119,945,917 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605423,811,217 - 23,814,235 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nppa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,147,974 - 1,148,927 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248181,147,654 - 1,149,722 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nppa
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1112,774,438 - 12,775,888 (-)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_005317468   ⟹   XP_005317525
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505834,846,575 - 34,848,274 (-)NCBI
SpeTri2.0NW_004936474671,362 - 673,610 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040287931   ⟹   XP_040143865
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505834,846,855 - 34,848,291 (-)NCBI
Protein Sequences
Protein RefSeqs XP_077883859 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AGC95107 (Get FASTA)   NCBI Sequence Viewer  
  KAG3282166 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005317525   ⟸   XM_005317468
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040143865   ⟸   XM_040287931
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00015015188 ENTREZGENE
InterPro Natr_peptide UniProtKB/TrEMBL
  Natriuretic_peptide_atrial UniProtKB/TrEMBL
NCBI Gene Nppa ENTREZGENE
Pfam ANP UniProtKB/TrEMBL
PRINTS ANATPEPTIDE UniProtKB/TrEMBL
UniProt L7X300_ICTTR UniProtKB/TrEMBL