PNPLA8 (patatin like phospholipase domain containing 8) - Rat Genome Database

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Pathways
Gene: PNPLA8 (patatin like phospholipase domain containing 8) Canis lupus familiaris
Analyze
Symbol: PNPLA8
Name: patatin like phospholipase domain containing 8
RGD ID: 12363276
Description: ENCODES a protein that exhibits A2-type glycerophospholipase activity (inferred); catalytic activity (inferred); glycerophospholipase activity (inferred); INVOLVED IN regulation of cellular response to oxidative stress (ortholog); ASSOCIATED WITH genetic disease (ortholog); Mitochondrial Myopathy with Lactic Acidosis (ortholog); FOUND IN mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calcium-independent phospholipase A2-gamma
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11812,134,921 - 12,181,496 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1812,141,830 - 12,179,974 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1811,779,378 - 11,825,993 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01812,406,088 - 12,453,716 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1812,406,080 - 12,454,928 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11812,223,261 - 12,270,831 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01812,143,880 - 12,191,247 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01812,371,185 - 12,418,564 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




References
Additional References at PubMed
PMID:30032202   PMID:35864734  


Genomics

Comparative Map Data
PNPLA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11812,134,921 - 12,181,496 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1812,141,830 - 12,179,974 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1811,779,378 - 11,825,993 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01812,406,088 - 12,453,716 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1812,406,080 - 12,454,928 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11812,223,261 - 12,270,831 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01812,143,880 - 12,191,247 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01812,371,185 - 12,418,564 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
PNPLA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387108,470,417 - 108,528,178 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7108,470,417 - 108,569,666 (-)Ensemblhg38GRCh38
GRCh377108,110,861 - 108,168,622 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367107,899,305 - 107,953,874 (-)NCBIBuild 36Build 36hg18NCBI36
Celera7102,925,427 - 102,979,992 (-)NCBICelera
Cytogenetic Map7q31.1NCBI
HuRef7102,479,082 - 102,536,797 (-)NCBIHuRef
CHM1_17108,044,179 - 108,101,909 (-)NCBICHM1_1
T2T-CHM13v2.07109,795,069 - 109,852,801 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27107,478,078 - 107,535,820 (-)NCBI
Pnpla8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391244,315,916 - 44,362,718 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1244,268,153 - 44,369,315 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381244,269,132 - 44,315,936 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1244,221,370 - 44,322,532 (+)Ensemblmm10GRCm38
MGSCv371245,370,141 - 45,414,424 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361245,139,472 - 45,182,573 (+)NCBIMGSCv36mm8
Celera1245,626,908 - 45,667,980 (+)NCBICelera
Cytogenetic Map12B2NCBI
cM Map1220.71NCBI
Pnpla8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8667,056,783 - 67,118,714 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl667,056,697 - 67,120,512 (+)EnsemblGRCr8
mRatBN7.2661,329,810 - 61,391,736 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl661,329,810 - 61,391,734 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx661,665,649 - 61,727,585 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0661,980,640 - 62,042,576 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0661,453,124 - 61,515,027 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0664,224,870 - 64,288,465 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl664,224,861 - 64,286,785 (+)Ensemblrn6Rnor6.0
Rnor_5.0673,814,201 - 73,876,147 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4663,644,462 - 63,676,544 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera660,325,313 - 60,388,908 (+)NCBICelera
RGSC_v3.1663,674,719 - 63,707,771 (+)NCBI
Cytogenetic Map6q21NCBI
Pnpla8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541012,711,082 - 12,753,433 (-)Ensembl
ChiLan1.0NW_00495541012,715,072 - 12,753,433 (-)NCBIChiLan1.0ChiLan1.0
PNPLA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26145,320,226 - 145,365,332 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17193,590,196 - 193,681,667 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07100,456,096 - 100,511,836 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17113,176,014 - 113,230,799 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7113,177,202 - 113,230,799 (-)EnsemblpanPan2panpan1.1
Pnpla8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511868,318,956 - 68,348,464 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366531,470,299 - 1,499,900 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366531,470,314 - 1,499,813 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9108,269,830 - 108,320,267 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19108,271,343 - 108,320,574 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29119,139,826 - 119,157,430 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PNPLA8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12177,385,923 - 77,437,894 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2177,385,537 - 77,437,860 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604226,424,768 - 26,477,705 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnpla8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473921,260,117 - 21,289,195 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473921,252,812 - 21,305,118 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pnpla8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1757,906,912 - 57,969,205 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in PNPLA8
500 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005630935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022405192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038423736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038423737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038423738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038500093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038500094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038500095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038562683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038562684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038562685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038626766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038626767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038626768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_533087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000005884   ⟹   ENSCAFP00000005450
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1812,141,830 - 12,179,974 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845039479   ⟹   ENSCAFP00845030937
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1812,406,080 - 12,452,779 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845039600   ⟹   ENSCAFP00845031023
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1812,406,085 - 12,454,928 (+)Ensembl
RefSeq Acc Id: XM_005630935   ⟹   XP_005630992
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11812,134,921 - 12,181,496 (+)NCBI
Dog10K_Boxer_Tasha1811,779,378 - 11,825,993 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022405192   ⟹   XP_022260900
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11812,134,921 - 12,168,584 (+)NCBI
Dog10K_Boxer_Tasha1811,779,378 - 11,812,706 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038423736   ⟹   XP_038279664
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01812,406,088 - 12,453,716 (+)NCBI
RefSeq Acc Id: XM_038423737   ⟹   XP_038279665
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01812,406,088 - 12,453,716 (+)NCBI
RefSeq Acc Id: XM_038423738   ⟹   XP_038279666
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01812,406,088 - 12,439,731 (+)NCBI
RefSeq Acc Id: XM_038500093   ⟹   XP_038356021
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11812,223,261 - 12,270,831 (+)NCBI
RefSeq Acc Id: XM_038500094   ⟹   XP_038356022
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11812,223,261 - 12,270,831 (+)NCBI
RefSeq Acc Id: XM_038500095   ⟹   XP_038356023
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11812,223,261 - 12,256,657 (+)NCBI
RefSeq Acc Id: XM_038562683   ⟹   XP_038418611
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01812,371,185 - 12,418,564 (+)NCBI
RefSeq Acc Id: XM_038562684   ⟹   XP_038418612
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01812,371,185 - 12,418,564 (+)NCBI
RefSeq Acc Id: XM_038562685   ⟹   XP_038418613
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01812,371,185 - 12,404,583 (+)NCBI
RefSeq Acc Id: XM_038626766   ⟹   XP_038482694
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01812,143,880 - 12,191,247 (+)NCBI
RefSeq Acc Id: XM_038626767   ⟹   XP_038482695
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01812,143,880 - 12,191,247 (+)NCBI
RefSeq Acc Id: XM_038626768   ⟹   XP_038482696
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01812,143,880 - 12,177,274 (+)NCBI
RefSeq Acc Id: XM_533087   ⟹   XP_533087
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11812,134,921 - 12,181,496 (+)NCBI
Dog10K_Boxer_Tasha1811,779,378 - 11,825,993 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005630992   ⟸   XM_005630935
- Peptide Label: isoform X1
- UniProtKB: A0A8C0S9W8 (UniProtKB/TrEMBL),   A0A8I3PEV9 (UniProtKB/TrEMBL),   A0A8C0PBD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_533087   ⟸   XM_533087
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PBD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022260900   ⟸   XM_022405192
- Peptide Label: isoform X4
- UniProtKB: A0A8I3PEJ7 (UniProtKB/TrEMBL),   A0A8P0S9B0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000005450   ⟸   ENSCAFT00000005884
RefSeq Acc Id: XP_038356021   ⟸   XM_038500093
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038356022   ⟸   XM_038500094
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038356023   ⟸   XM_038500095
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038482694   ⟸   XM_038626766
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038482695   ⟸   XM_038626767
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038482696   ⟸   XM_038626768
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038279664   ⟸   XM_038423736
- Peptide Label: isoform X1
- UniProtKB: A0A8C0S9W8 (UniProtKB/TrEMBL),   A0A8I3PEV9 (UniProtKB/TrEMBL),   A0A8C0PBD4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038279665   ⟸   XM_038423737
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PBD4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038279666   ⟸   XM_038423738
- Peptide Label: isoform X3
- UniProtKB: A0A8I3PEJ7 (UniProtKB/TrEMBL),   A0A8P0S9B0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038418611   ⟸   XM_038562683
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LK45 (UniProtKB/TrEMBL),   A0A8C0PBD4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038418612   ⟸   XM_038562684
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PBD4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038418613   ⟸   XM_038562685
- Peptide Label: isoform X3
- UniProtKB: A0A8I3PEJ7 (UniProtKB/TrEMBL),   A0A8P0S9B0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845031023   ⟸   ENSCAFT00845039600
Ensembl Acc Id: ENSCAFP00845030937   ⟸   ENSCAFT00845039479
Protein Domains
PNPLA

Promoters
RGD ID:13686436
Promoter ID:EPDNEW_C4502
Type:multiple initiation site
Name:PNPLA8_1
Description:patatin like phospholipase domain containing 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11812,134,964 - 12,135,024EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003661 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022754 UniProtKB/TrEMBL
  ENSCAFG00040011203 UniProtKB/TrEMBL
  ENSCAFG00845022366 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000005884.5 UniProtKB/TrEMBL
  ENSCAFT00000107650.1 UniProtKB/TrEMBL
  ENSCAFT00030041855.1 UniProtKB/TrEMBL
  ENSCAFT00030041931.1 UniProtKB/TrEMBL
  ENSCAFT00040020686.1 UniProtKB/TrEMBL
  ENSCAFT00845039479.1 UniProtKB/TrEMBL
  ENSCAFT00845039600 ENTREZGENE
  ENSCAFT00845039600.1 UniProtKB/TrEMBL
Gene3D-CATH Cytosolic phospholipase A2 catalytic domain UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPLipase UniProtKB/TrEMBL
  PNPLA8-like UniProtKB/TrEMBL
  PNPLA_dom UniProtKB/TrEMBL
KEGG Report cfa:475880 UniProtKB/TrEMBL
NCBI Gene PNPLA8 ENTREZGENE
PANTHER CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA UniProtKB/TrEMBL
  CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA UniProtKB/TrEMBL
Pfam Patatin UniProtKB/TrEMBL
PROSITE PNPLA UniProtKB/TrEMBL
Superfamily-SCOP SSF52151 UniProtKB/TrEMBL
UniProt A0A8C0LK45 ENTREZGENE
  A0A8C0PBD4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S9W8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PEJ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PEV9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0S9B0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44758 ENTREZGENE