MAP3K3 (mitogen-activated protein kinase kinase kinase 3) - Rat Genome Database

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Pathways
Gene: MAP3K3 (mitogen-activated protein kinase kinase kinase 3) Canis lupus familiaris
Analyze
Symbol: MAP3K3
Name: mitogen-activated protein kinase kinase kinase 3
RGD ID: 12156761
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); MAP kinase kinase kinase activity (inferred); INVOLVED IN blood vessel development (ortholog); intracellular signal transduction (ortholog); positive regulation of p38MAPK cascade (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; Erk5 MAPK signaling pathway; interleukin-1 signaling pathway; ASSOCIATED WITH Cerebral Cavernous Malformation 5 (ortholog); Esophageal Neoplasms (ortholog); verrucous keratotic hemangioma (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,612,527 - 11,678,407 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,612,994 - 11,675,838 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha912,572,499 - 12,638,395 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0913,276,493 - 13,339,186 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,276,310 - 13,338,713 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,220,815 - 12,286,279 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,245,905 - 15,311,520 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,248,794 - 15,314,683 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
MAP3K3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,612,527 - 11,678,407 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,612,994 - 11,675,838 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha912,572,499 - 12,638,395 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0913,276,493 - 13,339,186 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,276,310 - 13,338,713 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,220,815 - 12,286,279 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,245,905 - 15,311,520 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,248,794 - 15,314,683 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MAP3K3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,622,417 - 63,696,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,622,381 - 63,696,305 (+)Ensemblhg38GRCh38
GRCh371761,699,777 - 61,773,665 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,053,533 - 59,127,402 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341759,053,532 - 59,127,401NCBI
Celera1756,087,919 - 56,161,790 (+)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,077,975 - 57,141,816 (+)NCBIHuRef
CHM1_11761,764,216 - 61,838,082 (+)NCBICHM1_1
T2T-CHM13v2.01764,493,028 - 64,567,209 (+)NCBIT2T-CHM13v2.0
Map3k3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,975,358 - 106,047,482 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11105,975,439 - 106,046,272 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811106,084,587 - 106,156,656 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,084,613 - 106,155,446 (+)Ensemblmm10GRCm38
MGSCv3711105,946,216 - 106,016,760 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611105,900,992 - 105,971,536 (+)NCBIMGSCv36mm8
Celera11117,815,382 - 117,885,664 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.89NCBI
Map3k3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,519,976 - 91,588,651 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1091,519,888 - 91,588,651 (+)EnsemblGRCr8
mRatBN7.21091,020,174 - 91,088,852 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,020,174 - 91,088,848 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1096,075,116 - 96,143,482 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,538,287 - 95,606,652 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01090,949,010 - 91,017,411 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,280,703 - 94,349,372 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,280,703 - 94,349,368 (+)Ensemblrn6Rnor6.0
Rnor_5.01094,029,306 - 94,098,042 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41095,482,303 - 95,551,065 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1089,696,294 - 89,764,939 (+)NCBICelera
RGSC_v3.11095,496,690 - 95,565,451 (+)NCBI
Cytogenetic Map10q32.1NCBI
Map3k3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554788,125,436 - 8,199,253 (-)Ensembl
ChiLan1.0NW_0049554788,122,999 - 8,185,138 (-)NCBIChiLan1.0ChiLan1.0
MAP3K3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21979,794,119 - 79,868,489 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11784,611,585 - 84,685,943 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01757,702,242 - 57,776,601 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11762,858,655 - 62,922,874 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1762,858,635 - 62,922,874 (+)EnsemblpanPan2panpan1.1
Map3k3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,849,361 - 14,918,227 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,276,371 - 4,344,008 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,276,371 - 4,345,239 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,230,182 - 15,298,784 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11215,228,979 - 15,298,784 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,215,673 - 15,285,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11657,594,770 - 57,670,047 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1657,597,288 - 57,669,720 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607728,205,915 - 28,279,700 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,118,492 - 1,185,777 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248491,118,275 - 1,186,244 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Map3k3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1972,961,501 - 73,029,339 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in MAP3K3
604 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000038012   ⟹   ENSCAFP00000033671
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl911,612,994 - 11,675,838 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845034003   ⟹   ENSCAFP00845026610
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl913,276,310 - 13,338,713 (+)Ensembl
RefSeq Acc Id: XM_022422822   ⟹   XP_022278530
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1911,612,527 - 11,678,407 (+)NCBI
Dog10K_Boxer_Tasha912,572,499 - 12,638,395 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038485138   ⟹   XP_038341066
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1912,220,815 - 12,286,279 (+)NCBI
RefSeq Acc Id: XM_038546906   ⟹   XP_038402834
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0915,248,794 - 15,314,000 (-)NCBI
RefSeq Acc Id: XM_038546907   ⟹   XP_038402835
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0915,248,794 - 15,314,683 (-)NCBI
RefSeq Acc Id: XM_038610877   ⟹   XP_038466805
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0915,245,905 - 15,310,837 (-)NCBI
RefSeq Acc Id: XM_038610879   ⟹   XP_038466807
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0915,245,905 - 15,311,520 (-)NCBI
RefSeq Acc Id: XM_038675290   ⟹   XP_038531218
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0913,276,493 - 13,339,186 (+)NCBI
RefSeq Acc Id: XM_537600   ⟹   XP_537600
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1911,613,148 - 11,678,407 (+)NCBI
Dog10K_Boxer_Tasha912,573,183 - 12,638,395 (+)NCBI
Sequence:
RefSeq Acc Id: XP_537600   ⟸   XM_537600
- Peptide Label: isoform X7
- UniProtKB: A0A8C0LQY8 (UniProtKB/TrEMBL),   A0A8C0N5V6 (UniProtKB/TrEMBL),   A0A8P0NN13 (UniProtKB/TrEMBL),   A0A8C0SSR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022278530   ⟸   XM_022422822
- Peptide Label: isoform X8
- UniProtKB: A0A8C0SSR2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000033671   ⟸   ENSCAFT00000038012
RefSeq Acc Id: XP_038341066   ⟸   XM_038485138
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038466807   ⟸   XM_038610879
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038466805   ⟸   XM_038610877
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038531218   ⟸   XM_038675290
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SSR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038402835   ⟸   XM_038546907
- Peptide Label: isoform X6
- UniProtKB: A0A8C0SSR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038402834   ⟸   XM_038546906
- Peptide Label: isoform X5
- UniProtKB: A0A8C0LQY8 (UniProtKB/TrEMBL),   A0A8C0N5V6 (UniProtKB/TrEMBL),   A0A8C0SSR2 (UniProtKB/TrEMBL),   A0A8P0NN13 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845026610   ⟸   ENSCAFT00845034003
Protein Domains
PB1   Protein kinase

Promoters
RGD ID:13684456
Promoter ID:EPDNEW_C2525
Type:single initiation site
Name:MAP3K3_1
Description:mitogen-activated protein kinase kinase kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1911,613,273 - 11,613,333EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012934 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012134 UniProtKB/TrEMBL
  ENSCAFG00040015594 UniProtKB/TrEMBL
  ENSCAFG00845019265 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000038012.4 UniProtKB/TrEMBL
  ENSCAFT00030022491.1 UniProtKB/TrEMBL
  ENSCAFT00040028717.1 UniProtKB/TrEMBL
  ENSCAFT00845034003 ENTREZGENE
  ENSCAFT00845034003.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  PB1-like UniProtKB/TrEMBL
  PB1_dom UniProtKB/TrEMBL
  PB1_MEKK2/3 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
NCBI Gene MAP3K3 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 UniProtKB/TrEMBL
  SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam PB1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PB1 UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART PB1 UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0LQY8 ENTREZGENE
  A0A8C0N5V6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SSR2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PGC5_CANLF UniProtKB/TrEMBL
  A0A8P0NN13 ENTREZGENE
UniProt Secondary A0A8P0NN13 UniProtKB/TrEMBL
VGNC ID VGNC:42973 ENTREZGENE