TGFBRAP1 (transforming growth factor beta receptor associated protein 1) - Rat Genome Database

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Gene: TGFBRAP1 (transforming growth factor beta receptor associated protein 1) Canis lupus familiaris
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Symbol: TGFBRAP1
Name: transforming growth factor beta receptor associated protein 1
RGD ID: 12149531
Description: ENCODES a protein that exhibits SMAD binding (inferred); transforming growth factor beta receptor binding (inferred); INVOLVED IN endosomal vesicle fusion (inferred); endosome to lysosome transport (inferred); intracellular protein transport (inferred); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH long QT syndrome (ortholog); FOUND IN CORVET complex (inferred); cytoplasm (inferred); early endosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transforming growth factor-beta receptor-associated protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11038,096,407 - 38,159,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1038,095,547 - 38,157,506 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1038,021,631 - 38,084,686 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01038,952,430 - 39,015,760 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1038,953,286 - 39,015,555 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11038,677,282 - 38,739,914 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01038,956,356 - 39,019,382 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01039,148,381 - 39,211,069 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
CORVET complex  (IBA,IEA)
cytoplasm  (IBA,IEA)
early endosome  (IEA)
membrane  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TGFBRAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11038,096,407 - 38,159,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1038,095,547 - 38,157,506 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1038,021,631 - 38,084,686 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01038,952,430 - 39,015,760 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1038,953,286 - 39,015,555 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11038,677,282 - 38,739,914 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01038,956,356 - 39,019,382 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01039,148,381 - 39,211,069 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
TGFBRAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382105,249,404 - 105,329,735 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2105,264,359 - 105,329,735 (-)Ensemblhg38GRCh38
GRCh372105,865,861 - 105,946,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362105,249,961 - 105,312,561 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342105,342,059 - 105,404,647NCBI
Celera2100,084,016 - 100,146,596 (-)NCBICelera
Cytogenetic Map2q12.1-q12.2NCBI
HuRef299,652,442 - 99,693,661 (-)NCBIHuRef
CHM1_12105,887,841 - 105,929,095 (-)NCBICHM1_1
T2T-CHM13v2.02105,710,521 - 105,790,921 (-)NCBIT2T-CHM13v2.0
Tgfbrap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39143,086,360 - 43,137,788 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl143,086,360 - 43,137,797 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38143,047,200 - 43,098,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl143,047,200 - 43,098,637 (-)Ensemblmm10GRCm38
MGSCv37143,104,114 - 43,155,467 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36142,991,815 - 43,043,168 (-)NCBIMGSCv36mm8
Celera143,385,583 - 43,437,075 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map122.13NCBI
Tgfbrap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8952,813,087 - 52,863,441 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl952,813,087 - 52,863,441 (-)EnsemblGRCr8
mRatBN7.2945,320,975 - 45,371,329 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl945,320,930 - 45,371,311 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx953,815,752 - 53,865,936 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0958,938,553 - 58,988,735 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0957,218,826 - 57,269,178 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd956,584,383 - 56,634,733 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive952,359,687 - 52,410,033 (-)NCBILyon_Normotensive
Lyon_Hypertensive952,495,187 - 52,545,537 (-)NCBILyon_Hypertensive
F344_StmMcwi954,411,486 - 54,461,840 (-)NCBIF344_StmMcwi
Rnor_6.0949,852,560 - 49,902,943 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl949,852,560 - 49,902,943 (-)Ensemblrn6Rnor6.0
Rnor_5.0949,523,134 - 49,573,517 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4942,251,501 - 42,301,886 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera943,038,902 - 43,089,223 (-)NCBICelera
RGSC_v3.1942,255,317 - 42,280,535 (-)NCBI
Cytogenetic Map9q22NCBI
Tgfbrap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547010,176,607 - 10,223,234 (-)Ensembl
ChiLan1.0NW_00495547010,178,936 - 10,223,234 (-)NCBIChiLan1.0ChiLan1.0
TGFBRAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21222,388,353 - 22,466,069 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A22,391,136 - 22,468,834 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A96,500,444 - 96,578,068 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A106,338,088 - 106,394,327 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A106,338,098 - 106,394,327 (-)EnsemblpanPan2panpan1.1
Tgfbrap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629287,252,589 - 87,324,664 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936764701,116 - 747,621 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936764675,615 - 747,613 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBRAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl349,466,903 - 49,521,875 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1349,469,898 - 49,521,879 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2351,797,929 - 51,849,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TGFBRAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1148,900,342 - 8,963,107 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl148,898,587 - 8,942,148 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041176,618,479 - 176,684,106 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfbrap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247499,384,883 - 9,432,565 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247499,384,996 - 9,432,612 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tgfbrap1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14119,202,010 - 119,249,766 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in TGFBRAP1
978 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022424546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038643695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038643706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038643714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038680176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038680177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038680178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_538441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000003341   ⟹   ENSCAFP00000003101
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1038,119,713 - 38,157,506 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000077255   ⟹   ENSCAFP00000064842
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1038,095,547 - 38,155,620 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845017217   ⟹   ENSCAFP00845013419
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1038,953,286 - 39,015,555 (+)Ensembl
RefSeq Acc Id: XM_038488927   ⟹   XP_038344855
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11038,677,282 - 38,739,914 (+)NCBI
RefSeq Acc Id: XM_038550896   ⟹   XP_038406824
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01039,148,381 - 39,211,069 (+)NCBI
RefSeq Acc Id: XM_038614806   ⟹   XP_038470734
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01038,956,723 - 39,019,382 (+)NCBI
RefSeq Acc Id: XM_038614807   ⟹   XP_038470735
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01038,956,356 - 39,019,382 (+)NCBI
RefSeq Acc Id: XM_038614808   ⟹   XP_038470736
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01038,956,723 - 39,015,315 (+)NCBI
RefSeq Acc Id: XM_038643695   ⟹   XP_038499623
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1038,022,011 - 38,084,686 (+)NCBI
RefSeq Acc Id: XM_038643706   ⟹   XP_038499634
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1038,021,631 - 38,084,686 (+)NCBI
RefSeq Acc Id: XM_038643714   ⟹   XP_038499642
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1038,022,011 - 38,080,614 (+)NCBI
RefSeq Acc Id: XM_038680176   ⟹   XP_038536104
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01038,952,840 - 39,015,760 (+)NCBI
RefSeq Acc Id: XM_038680177   ⟹   XP_038536105
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01038,952,430 - 39,015,760 (+)NCBI
RefSeq Acc Id: XM_038680178   ⟹   XP_038536106
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01038,952,840 - 39,011,689 (+)NCBI
Ensembl Acc Id: ENSCAFP00000064842   ⟸   ENSCAFT00000077255
Ensembl Acc Id: ENSCAFP00000003101   ⟸   ENSCAFT00000003341
RefSeq Acc Id: XP_038344855   ⟸   XM_038488927
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038470735   ⟸   XM_038614807
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038470734   ⟸   XM_038614806
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038470736   ⟸   XM_038614808
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038536105   ⟸   XM_038680177
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NCS7 (UniProtKB/TrEMBL),   A0A8C0K9F1 (UniProtKB/TrEMBL),   A0A8C0QQC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038536104   ⟸   XM_038680176
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NCS7 (UniProtKB/TrEMBL),   A0A8C0K9F1 (UniProtKB/TrEMBL),   A0A8C0QQC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038536106   ⟸   XM_038680178
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038499634   ⟸   XM_038643706
- Peptide Label: isoform X1
- UniProtKB: A0A8P0S8B0 (UniProtKB/TrEMBL),   A0A8C0QQC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038499623   ⟸   XM_038643695
- Peptide Label: isoform X1
- UniProtKB: A0A8P0S8B0 (UniProtKB/TrEMBL),   A0A8C0QQC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038499642   ⟸   XM_038643714
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038406824   ⟸   XM_038550896
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QQC6 (UniProtKB/TrEMBL),   A0A8P0S8B0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845013419   ⟸   ENSCAFT00845017217
Protein Domains
CNH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002112 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040007535 UniProtKB/TrEMBL
  ENSCAFG00845009768 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003341.5 UniProtKB/TrEMBL
  ENSCAFT00040014078.1 UniProtKB/TrEMBL
  ENSCAFT00845017217 ENTREZGENE
  ENSCAFT00845017217.1 UniProtKB/TrEMBL
InterPro Clathrin_H-chain/VPS_repeat UniProtKB/TrEMBL
  CNH_dom UniProtKB/TrEMBL
  Vam6/VPS39/TRAP1 UniProtKB/TrEMBL
  VPS39/TGF_beta_rcpt-assoc_1 UniProtKB/TrEMBL
  VPS39/TGF_beta_rcpt-assoc_2 UniProtKB/TrEMBL
NCBI Gene TGFBRAP1 ENTREZGENE
PANTHER PTHR12894 UniProtKB/TrEMBL
  TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1 UniProtKB/TrEMBL
Pfam CNH UniProtKB/TrEMBL
  Vps39_1 UniProtKB/TrEMBL
  Vps39_2 UniProtKB/TrEMBL
PROSITE CHCR UniProtKB/TrEMBL
  CNH UniProtKB/TrEMBL
UniProt A0A8C0K9F1 ENTREZGENE
  A0A8C0QQC6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NCS7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0S8B0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:47313 ENTREZGENE