PRODH2 (proline dehydrogenase 2) - Rat Genome Database

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Gene: PRODH2 (proline dehydrogenase 2) Canis lupus familiaris
Analyze
Symbol: PRODH2
Name: proline dehydrogenase 2
RGD ID: 12069456
Description: ENCODES a protein that exhibits oxidoreductase activity (inferred); oxidoreductase activity, acting on the CH-NH group of donors (inferred); proline dehydrogenase activity (inferred); INVOLVED IN L-proline catabolic process (inferred); L-proline metabolic process (inferred); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hydroxyproline dehydrogenase; probable proline dehydrogenase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,831,722 - 116,842,698 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,831,722 - 116,916,278 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1116,237,189 - 116,247,915 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01117,434,889 - 117,445,619 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,434,889 - 117,445,619 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,998,294 - 117,009,017 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,621,797 - 116,632,644 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,677,246 - 117,687,980 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PRODH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,831,722 - 116,842,698 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,831,722 - 116,916,278 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1116,237,189 - 116,247,915 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01117,434,889 - 117,445,619 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,434,889 - 117,445,619 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,998,294 - 117,009,017 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,621,797 - 116,632,644 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,677,246 - 117,687,980 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
PRODH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,799,988 - 35,812,845 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,799,975 - 35,813,299 (-)Ensemblhg38GRCh38
GRCh371936,290,890 - 36,303,747 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,982,732 - 40,996,041 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341940,982,731 - 40,996,041NCBI
Celera1933,004,365 - 33,017,674 (-)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,795,750 - 32,809,099 (-)NCBIHuRef
CHM1_11936,292,192 - 36,305,500 (-)NCBICHM1_1
T2T-CHM13v2.01938,345,290 - 38,358,148 (-)NCBIT2T-CHM13v2.0
Prodh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,193,011 - 30,212,830 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,193,047 - 30,212,827 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38730,493,586 - 30,513,402 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,493,622 - 30,513,402 (+)Ensemblmm10GRCm38
MGSCv37731,278,677 - 31,298,421 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36730,202,418 - 30,222,162 (+)NCBIMGSCv36mm8
Celera725,084,968 - 25,104,699 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map718.36NCBI
Prodh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,881,000 - 94,894,609 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl194,881,061 - 94,894,609 (+)EnsemblGRCr8
mRatBN7.2185,753,558 - 85,767,165 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,753,644 - 85,767,162 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx191,170,442 - 91,183,855 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,636,602 - 99,650,023 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,928,723 - 92,942,134 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd193,497,059 - 93,510,565 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive198,639,509 - 98,653,067 (+)NCBILyon_Normotensive
Lyon_Hypertensive195,172,804 - 95,186,362 (+)NCBILyon_Hypertensive
F344_StmMcwi193,624,081 - 93,637,603 (+)NCBIF344_StmMcwi
Rnor_6.0188,955,125 - 88,968,501 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,955,135 - 88,968,501 (+)Ensemblrn6Rnor6.0
Rnor_5.0190,110,667 - 90,123,506 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4185,546,014 - 85,559,530 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera180,125,644 - 80,138,959 (+)NCBICelera
RGSC_v3.1185,624,134 - 85,637,586 (+)NCBI
Cytogenetic Map1q21NCBI
Prodh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,747,862 - 2,754,592 (+)Ensembl
ChiLan1.0NW_0049554682,747,870 - 2,754,621 (+)NCBIChiLan1.0ChiLan1.0
PRODH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,783,171 - 41,807,083 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,776,415 - 43,792,468 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,713,686 - 32,726,964 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,462,685 - 41,475,915 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,462,735 - 41,476,308 (-)EnsemblpanPan2panpan1.1
Prodh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,114,580 - 11,123,661 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570522,290 - 531,241 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936570522,275 - 531,300 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRODH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,226,332 - 45,240,442 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1645,213,712 - 45,240,437 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,673,972 - 40,688,103 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRODH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,709,269 - 30,723,735 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,709,488 - 30,723,356 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660738,501,244 - 8,515,103 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prodh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479410,098,737 - 10,104,212 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prodh2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12165,495,942 - 165,509,708 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in PRODH2
145 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
4 4 3 12 14 13 6 6 6 4 24 14 7 13 7

Sequence


Ensembl Acc Id: ENSCAFT00000010897   ⟹   ENSCAFP00000010099
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1116,831,722 - 116,842,698 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000081253   ⟹   ENSCAFP00000051431
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1116,831,722 - 116,916,278 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845001888   ⟹   ENSCAFP00845001485
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1117,434,889 - 117,445,619 (+)Ensembl
RefSeq Acc Id: NM_001313832   ⟹   NP_001300761
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11116,831,722 - 116,842,698 (+)NCBI
Dog10K_Boxer_Tasha1116,237,189 - 116,247,915 (+)NCBI
ROS_Cfam_1.01117,434,889 - 117,445,619 (+)NCBI
UMICH_Zoey_3.11116,998,294 - 117,009,017 (+)NCBI
UNSW_CanFamBas_1.01116,621,797 - 116,632,644 (+)NCBI
UU_Cfam_GSD_1.01117,677,246 - 117,687,980 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001300761 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CBX85298 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000010099.3
  ENSCAFP00030011309.1
  ENSCAFP00040034428.1
  ENSCAFP00845001485
  ENSCAFP00845001485.1
RefSeq Acc Id: NP_001300761   ⟸   NM_001313832
- UniProtKB: A0A8I3RR96 (UniProtKB/TrEMBL),   A0A8C0TE73 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000010099   ⟸   ENSCAFT00000010897
Ensembl Acc Id: ENSCAFP00000051431   ⟸   ENSCAFT00000081253
Ensembl Acc Id: ENSCAFP00845001485   ⟸   ENSCAFT00845001888
Protein Domains
Proline dehydrogenase

Promoters
RGD ID:13682339
Promoter ID:EPDNEW_C409
Type:initiation region
Name:PRODH2_1
Description:Canis lupus familiaris proline dehydrogenase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11116,831,784 - 116,831,844EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006767 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030007052 UniProtKB/TrEMBL
  ENSCAFG00040021259 UniProtKB/TrEMBL
  ENSCAFG00845001097 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010897.4 UniProtKB/TrEMBL
  ENSCAFT00030012940.1 UniProtKB/TrEMBL
  ENSCAFT00040039455.1 UniProtKB/TrEMBL
  ENSCAFT00845001888 ENTREZGENE
  ENSCAFT00845001888.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.220 UniProtKB/TrEMBL
InterPro FAD-linked_oxidoreductase-like UniProtKB/TrEMBL
  Proline_DH_dom UniProtKB/TrEMBL
  Proline_oxidase UniProtKB/TrEMBL
KEGG Report cfa:484572 UniProtKB/TrEMBL
NCBI Gene PRODH2 ENTREZGENE
PANTHER HYDROXYPROLINE DEHYDROGENASE UniProtKB/TrEMBL
  PTHR13914 UniProtKB/TrEMBL
Pfam Pro_dh UniProtKB/TrEMBL
Superfamily-SCOP SSF51730 UniProtKB/TrEMBL
UniProt A0A8C0MTA1_CANLF UniProtKB/TrEMBL
  A0A8C0TE73 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RR96 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8P0SC17 UniProtKB/TrEMBL
VGNC ID VGNC:45009 ENTREZGENE