PRODH2 (proline dehydrogenase 2) - Rat Genome Database

Name: PRODH2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: PRODH2 (proline dehydrogenase 2) Chlorocebus sabaeus

Analyze

Symbol:

PRODH2

Name:

proline dehydrogenase 2

RGD ID:

18649976

Description:

ENCODES a protein that exhibits oxidoreductase activity, acting on the CH-NH group of donors (ortholog); INVOLVED IN proline catabolic process (inferred); proline catabolic process to glutamate (inferred); proline metabolic process (inferred); ASSOCIATED WITH Brugada syndrome 5 (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

hydroxyproline dehydrogenase; probable proline dehydrogenase 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	30,709,269 - 30,723,735 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	30,709,488 - 30,723,356 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	8,501,244 - 8,515,103 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brugada syndrome 5 (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 75 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proline catabolic process (IEA)

proline catabolic process to glutamate (IEA)

proline metabolic process (IEA)

Cellular Component

mitochondrion (IEA)

Molecular Function

FAD binding (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the CH-NH group of donors (ISO)

proline dehydrogenase activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

PRODH2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	30,709,269 - 30,723,735 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	30,709,488 - 30,723,356 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	8,501,244 - 8,515,103 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

PRODH2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	35,799,988 - 35,812,845 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	35,799,988 - 35,813,299 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	36,290,890 - 36,303,747 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	40,982,732 - 40,996,041 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	40,982,731 - 40,996,041	NCBI
Celera	19	33,004,365 - 33,017,674 (-)	NCBI		Celera
Cytogenetic Map	19	q13.12	NCBI
HuRef	19	32,795,750 - 32,809,099 (-)	NCBI		HuRef
CHM1_1	19	36,292,192 - 36,305,500 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	38,345,290 - 38,358,148 (-)	NCBI		T2T-CHM13v2.0

Prodh2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	30,193,011 - 30,212,830 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	30,193,047 - 30,212,827 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	30,493,586 - 30,513,402 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	30,493,622 - 30,513,402 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	31,278,677 - 31,298,421 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	30,202,418 - 30,222,162 (+)	NCBI		MGSCv36	mm8
Celera	7	25,084,968 - 25,104,699 (+)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	18.36	NCBI

Prodh2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	94,881,000 - 94,894,609 (+)	NCBI		GRCr8
mRatBN7.2	1	85,753,558 - 85,767,165 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	85,753,644 - 85,767,162 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	91,170,442 - 91,183,855 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	99,636,602 - 99,650,023 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	92,928,723 - 92,942,134 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	88,955,125 - 88,968,501 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	88,955,135 - 88,968,501 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	90,110,667 - 90,123,506 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	85,546,014 - 85,559,530 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	85,624,134 - 85,637,586 (+)	NCBI
Celera	1	80,125,644 - 80,138,959 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

Prodh2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	2,747,862 - 2,754,592 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	2,747,870 - 2,754,621 (+)	NCBI	ChiLan1.0	ChiLan1.0

PRODH2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	41,783,171 - 41,807,083 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	43,776,415 - 43,792,468 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	32,713,686 - 32,726,964 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	41,462,685 - 41,475,915 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	41,462,735 - 41,476,308 (-)	Ensembl	panpan1.1		panPan2

PRODH2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	116,831,722 - 116,842,698 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	116,831,722 - 116,916,278 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	116,237,189 - 116,247,915 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	117,434,889 - 117,445,619 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	117,434,889 - 117,445,619 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	116,998,294 - 117,009,017 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	116,621,797 - 116,632,644 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	117,677,246 - 117,687,980 (+)	NCBI		UU_Cfam_GSD_1.0

Prodh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	11,114,580 - 11,123,661 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936570	522,290 - 531,241 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936570	522,275 - 531,300 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRODH2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	45,213,712 - 45,240,437 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	40,673,972 - 40,688,103 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Prodh2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624794	10,098,737 - 10,104,212 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low		12	22
Below cutoff	7	5	20

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007998482	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000002354 ⟹ ENSCSAP00000000669

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	6	30,709,488 - 30,723,356 (-)	Ensembl

RefSeq Acc Id:

XM_007998482 ⟹ XP_007996673

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	6	30,709,269 - 30,723,735 (-)	NCBI
Vero_WHO_p1.0	NW_023666073	8,501,244 - 8,515,103 (-)	NCBI

Sequence:

show sequence

ATGCCCAAACCAGGGGTGATTAATGTCACTGCCCCCAGTCTGGGCAAGGGGCAGTTGGTGAACC
TGCTGCCTCCAGAGCACCTTCCCTGGTGTGGAGGCAGCCAGGGACCCAGGATGCTCCGGACCTG
TTACCCGCTCTGTTCCCAAGCTGGTCCCCTGGCGAGGGGCTGGCAGCCCCTGAGCTTTGATGGT
GGCGCCTTCCACCTCAAGGGCACAGGAGAGCTGACACGGGCCTTGCTGGTTCTCCGGCTGTGTG
CTTGGCCCCCACTCGTCACTCACGGGCTGGCGCTCCAGGCCTGGTCTCAGCGACTCCTGGGCTC
CCGGCTCTCAGGCGCGTTTCTCCGAGCATCCGTCTATGGGCAGTTTGTGGCTGGTGAGACAGTA
GAGGAGGTGAGGGGCTGTGTGCAGCAGCTGCGGACCCTCAGCCTCCGACCACTGCTGGCAGTGC
CCACTGAGGAGGAGCCGGACTCTGCTGCCAAGAGCGGTGAGGCCTGGTATGAGGGGAACCTCGG
CGCTATGCTGCGGTGTGTGGACCTGTCGCGGGACCTCCTGGAGCCCCCCAGCCTGGCTGAAGCC
AGCCTCATGCAGCTGAAGGTGACGGCGCTGACCAGCGCTCGGCTCTGTAAGGAGCTAGCCTCAT
GGGTCAGAAGGCCAGGAGCCTCCTTGGAGCTGAGCCCCGAGAGGCTGGCTGAAGCCATGGACTC
TGGGCAGAACCTCCAGGTCTCCTGCCTCAACAACGAGCAGAACCAGCACCTCCAGGCCTCCCTC
AGCCGCTTGCATCGGGTGGCCCAGTATGCCCGGGCCCAGCACGTGCGGCTCCTGGTGGATGCGG
AGTACACCTCACTGAACCCTGCGCTCTCGCTGCTGGTGGCTGCCCTGGCCGTGCGCTGGAACAG
CCCAGGGGAAGGCGGGCCCTGGGTGTGGAACACCTACCAGGCCTGTCTAAAGGACACATTCGAG
CGGCTGGGGAGGGACGCAGAGGCCGCACACAGGGCCGGCCTGGCCTTTGGAGTGAAGCTGGTAC
GAGGTGCCTATCTGGACAAGGAGAGAGCGGTGGCCCAGCTTCATGGGATGAAGGACCCCACTCA
GCCTGACTATGAGGCCACCAGTCAGAGTTACAGCCGCTGCCTGGAACTGATGCTGACGCGCGTG
GCCCGCCACGGCCCCATGTGCCACCTCATGGTGGCTTCCCACAATGAGGAATCTGTTCGCCAGG
CAACCAAGCGCATGTGGGAGCTGGGCATTCCTCTGGACGGGACTGTCTGTTTCGGACAACTTCT
GGGCATGTGTGACCACGTCTCTCTGGCACTGGGGCAGGCCGGCTATGTAGTGTATAAGTCCATC
CCCTATGGCTCCTTGGAGGAGGTAATCCCCTACCTGATCCGGAGGGCCCAGGAAAACCGGAGCG
TGCTTCAGGGTGTCCGCAGGGAACAGGAGCTGCTCAGCCAAGAACTGTGGCGGCGCCTGCTGCC
AGGACGCCGAAGGATACCCCACTAGCACCCCTGAGGGGGTCATGTGGTCAATAAAGGTCCTTAG
GCACTGCCGAAGCTGCTGTCCTGCACTGACACCGCCTCCTTGTGGAAGGGCTCATCTTGACCTC
AGCCAGTCCAAGCTAGGGGTTTTGCAATTCAAGAGAGATCGTTAGGCTGGGAGTGGTGGCTCTT
GCCTATAATCCCAGTGCTTTGGGAGGCCAAGGTGGGAGGCTTCCTTCAGTTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_007996673	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000000669.1

RefSeq Acc Id:	XP_007996673 ⟸ XM_007998482
- UniProtKB:	A0A0D9QWD0 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000000669 ⟸ ENSCSAT00000002354

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000004325	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000002354.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.220	UniProtKB/TrEMBL
InterPro	FAD-linked_oxidoreductase-like	UniProtKB/TrEMBL
	Proline_DH_dom	UniProtKB/TrEMBL
	Proline_oxidase	UniProtKB/TrEMBL
NCBI Gene	PRODH2	ENTREZGENE
PANTHER	HYDROXYPROLINE DEHYDROGENASE	UniProtKB/TrEMBL
	PTHR13914	UniProtKB/TrEMBL
Pfam	Pro_dh	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51730	UniProtKB/TrEMBL
UniProt	A0A0D9QWD0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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