| 11760360 | CALY | calcyon neuron specific vesicular protein | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); positive regulation of clathrin coat assembly (ortholog); positive regulation of retrograde axon cargo transport (ortholog); ASSOCIATED WITH Animal Disease Models (orth olog); attention deficit hyperactivity disorder (ortholog); essential hypertension (ortholog); FOUND IN axon (ortholog) | | | | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11750528 | AAK1 | AP2 associated kinase 1 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); ATP binding (inferred); kinase activity (inferred); INVOLVED IN protein phosphorylation (ortholog); ASSOCIATED WITH tooth agenesis (ortholog); FOUND IN calyx of Held (ortholog); cell leadin g edge (ortholog); clathrin complex (ortholog) | 2A | 69506651 | 69686765 | Bonobo | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 11713607 | ATP1A3 | ATPase Na+/K+ transporting subunit alpha 3 | ENCODES a protein that exhibits amyloid-beta binding (ortholog); D1 dopamine receptor binding (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); blood circulation (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ort holog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 2 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | 19 | 38854243 | 38882034 | Bonobo | 267 | description | gene, protein-coding, MODEL [RefSeq] |
| 11813415 | CACNA1A | calcium voltage-gated channel subunit alpha1 A | ENCODES a protein that exhibits calmodulin binding (ortholog); high voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Alternating Hemiplegia of Childhood 1 (ortholog); amyotrophic lateral sclerosis (ortholog); Ataxia (ortholog); FOUND IN calyx of Held (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | 19 | 12769586 | 13189022 | Bonobo | 240 | description | gene, protein-coding, MODEL [RefSeq] |
| 11906641 | CALB1 | calbindin 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cochlea development (ortholog); learning or memory (ortholog); locomotory behavior (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); bilirubin metabolic disorder (ortholog); gestational diabetes (ortholog); FOUND IN calyx of Held (ortholog); cuticular plate (ortholog); neuronal cell body (ortholog) | 8 | 86747702 | 86771995 | Bonobo | 66 | description | gene, protein-coding, MODEL [RefSeq] |
| 11901849 | CCIN | calicin | INVOLVED IN cell differentiation (inferred); spermatogenesis (inferred); ASSOCIATED WITH spermatogenic failure 91 (ortholog); FOUND IN cytoskeletal calyx (inferred); perinuclear theca (inferred); sperm glycocalyx (inferred) | 9 | 36014394 | 36021056 | Bonobo | 13 | description | gene, protein-coding, MODEL [RefSeq] |
| 11667972 | CYLC2 | cylicin 2 | ENCODES a protein that exhibits structural constituent of cytoskeleton (inferred); INVOLVED IN acrosome assembly (ortholog); maintenance of cell number (ortholog); manchette assembly (ortholog); FOUND IN cytoskeletal calyx (inferred); nucleus (inferred); perinuc lear theca (inferred) | 9 | 74188934 | 74208842 | Bonobo | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 11838896 | GIT2 | GIT ArfGAP 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH inflammatory bowel disease (ortholog); FOUND IN calyx of Held (ortholog); presynapse (ortholog) | 12 | 107505791 | 107572641 | Bonobo | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 11814475 | GLRA1 | glycine receptor alpha 1 | ENCODES a protein that exhibits extracellularly glycine-gated chloride channel activity (ortholog); extracellularly glycine-gated ion channel activity (ortholog); glycine binding (ortholog); INVOLVED IN acrosome reaction (ortholog); action potential (ortholog); adult walking behavior (ortholog); PAR TICIPATES IN Inhibitory synaptic transmission pathway; ASSOCIATED WITH dystonia (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); endoplasmic reticulum (ortholog); postsynaptic specialization membrane (ortholog) | 5 | 147245741 | 147348555 | Bonobo | 100 | description | gene, protein-coding, MODEL [RefSeq] |
| 11994364 | HTR1B | 5-hydroxytryptamine receptor 1B | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); heterocyclic compound binding (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN bone remodeling (ortholog); chemical synap tic transmission (ortholog); drinking behavior (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); amphetamine abuse (ortholog); Anorexia (ortholog); FOUND IN calyx of Held (ortholog) | 6 | 75309078 | 75313747 | Bonobo | 99 | description | gene, protein-coding, MODEL [RefSeq] |
| 11751332 | ITSN1 | intersectin 1 | ENCODES a protein that exhibits kinase activator activity (ortholog); INVOLVED IN cell-cell signaling (ortholog); endocytosis (ortholog); negative regulation of neuron apoptotic process (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ephrin - ephrin receptor bidirectiona l signaling axis; ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); esophageal atresia/tracheoesophageal fistula (ortholog); FOUND IN apical dendrite (ortholog); calyx of Held (ortholog); clathrin-coated pit (ortholog) | 21 | 20009385 | 20266835 | Bonobo | 94 | description | gene, protein-coding, MODEL [RefSeq] |
| 12041426 | KCNA1 | potassium voltage-gated channel subfamily A member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane po tential (ortholog); INVOLVED IN axon development (ortholog); cell communication by electrical coupling (ortholog); cerebral cortex development (ortholog); ASSOCIATED WITH epilepsy (ortholog); epilepsy with generalized tonic-clonic seizures (ortholog); episodic ataxia (ortholog); FOUND IN apical plasma membrane (ortholog); calyx of Held (ortholog); cell surface (ortholog) | 12 | 5027333 | 5037136 | Bonobo | 101 | description | gene, protein-coding, MODEL [RefSeq] |
| 11771955 | KCNA2 | potassium voltage-gated channel subfamily A member 2 | ENCODES a protein that exhibits kinesin binding (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); INVOLVED IN cerebral cortex development (ortholog); corpus callosum development (ortholog); neuronal action potential (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 1 (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); lamellipodium (ortholog) | 1 | 113187158 | 113256260 | Bonobo | 85 | description | gene, protein-coding, MODEL [RefSeq] |
| 11690385 | KCNA3 | potassium voltage-gated channel subfamily A member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); potassium ion transmembrane transport (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); glutamatergic synapse (ortholog) | 1 | 113304340 | 113323367 | Bonobo | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 11952710 | KCNC1 | potassium voltage-gated channel subfamily C member 1 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); cerebellum development (ortholog); corpus callosum development (ortholog); ASSOCIATED WI TH Alzheimer's disease (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); cell surface (ortholog); dendrite (ortholog) | 11 | 17788010 | 17936591 | Bonobo | 79 | description | gene, protein-coding, MODEL [RefSeq] |
| 11680584 | KCNC3 | potassium voltage-gated channel subfamily C member 3 | ENCODES a protein that exhibits voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); cortical actin cytoskeleton organization (ortholog); optic nerve development (ortholog); ASSOCIATED WITH genetic disease (ortholog); spinocerebellar ataxia 13 (ort holog); FOUND IN axolemma (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | 19 | 47275213 | 47296809 | Bonobo | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 12018879 | KCNC4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | 1 | 112860887 | 112884687 | Bonobo | 60 | description | gene, protein-coding, MODEL [RefSeq] |
| 11723174 | KCNQ5 | potassium voltage-gated channel subfamily Q member 5 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual deve lopmental disorder (ortholog); autosomal dominant intellectual developmental disorder 46 (ortholog); congenital diaphragmatic hernia (ortholog); FOUND IN calyx of Held (ortholog); presynaptic membrane (ortholog) | 6 | 70448161 | 71025173 | Bonobo | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 11992394 | NCS1 | neuronal calcium sensor 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); magnesium ion binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of calcium-mediated signaling (ortholog); positive regulation of exocytosis (ortholog); regulation of neuron projection development (or tholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; FOUND IN calyx of Held (ortholog); dense core granule (ortholog); glutamatergic synapse (ortholog) | 9 | 101299724 | 101364897 | Bonobo | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 12041736 | RIMBP2 | RIMS binding protein 2 | ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); structural constituent of presynaptic active zone (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of calcium-depende nt activation of synaptic vesicle fusion (ortholog); regulation of presynaptic membrane potential (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); presynaptic active zone cytoplasmic component (ortholog) | 12 | 128009575 | 128338009 | Bonobo | 16 | description | gene, protein-coding, MODEL [RefSeq] |
| 11714436 | TPRG1L | tumor protein p63 regulated 1 like | ENCODES a protein that exhibits calmodulin binding (ortholog); identical protein binding (ortholog); INVOLVED IN calcineurin-NFAT signaling cascade (ortholog); negative regulation of synaptic transmission (ortholog); regulation of synaptic transmission, glutamatergic (ortholog); FOUND IN caly ='font-weight:700;'>calyx of Held (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | 1 | 2296601 | 2301687 | Bonobo | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 11924019 | TSPOAP1 | TSPO associated protein 1 | ENCODES a protein that exhibits benzodiazepine receptor binding (inferred); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (inferred); INVOLVED IN regulation of neurotransmitter secretion (inferred); regulation of presynaptic cytosolic calcium i on concentration (inferred); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); COVID-19 (ortholog); dystonia (ortholog); FOUND IN calyx of Held (inferred); cytoplasm (inferred); glutamatergic synapse (inferred) | 17 | 52376707 | 52404160 | Bonobo | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 11736397 | UNC13A | unc-13 homolog A | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); dense core granule docking (ortholog); innervation (ortholog); PARTICIPATES IN insul in secretion pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); autistic disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); excitatory synapse (ortholog) | 19 | 17088654 | 17175559 | Bonobo | 83 | description | gene, protein-coding, MODEL [RefSeq] |
| 11739172 | UNC13B | unc-13 homolog B | ENCODES a protein that exhibits GTP-dependent protein binding (ortholog); syntaxin binding (ortholog); INVOLVED IN acrosomal vesicle exocytosis (ortholog); cellular response to glucose stimulus (ortholog); chemical synaptic transmission (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN caly style='font-weight:700;'>calyx of Held (ortholog); cytosol (ortholog); early phagosome (ortholog) | 9 | 35011350 | 35255148 | Bonobo | 71 | description | gene, protein-coding, MODEL [RefSeq] |
| 11864531 | UNC13C | unc-13 homolog C | ENCODES a protein that exhibits calmodulin binding (ortholog); syntaxin binding (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); negative regulation of synaptic plasticity (ortholog); synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH clubfoot (o rtholog); FOUND IN calyx of Held (ortholog); parallel fiber to Purkinje cell synapse (ortholog); presynapse (ortholog) | 15 | 32914784 | 33563610 | Bonobo | 14 | description | gene, protein-coding, MODEL [RefSeq] |