| 1332440 | Shroom1 | shroom family member 1 | Enables actin filament binding activity and myosin II binding activity. Involved in actin filament bundle assembly and cell morphogenesis. Predicted to be located in cytoplasm and microtubule. Predicted to be active in several cellular components, including adherens junction; apical junction complex ; and apical plasma membrane. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Orthologous to human SHROOM1 (shroom family member 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 53347904 | 53358593 | Mouse | 80 | symbol , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1614985 | Shroom2 | shroom family member 2 | Enables actin filament binding activity; beta-catenin binding activity; and protein domain specific binding activity. Involved in cell migration and melanosome organization. Acts upstream of or within cell-cell junction maintenance and negative regulation of actin filament depolymerization. Located in several cellular components, including adherens junction; apical plasma membrane; and bicellular tight junction. Colocalizes with cortical actin cytoskeleton. Is expressed in several structures, including blood vessel; central nervous system; epithelium; inner ear; and retina inner plexiform layer. Orthologous to human SHROOM2 (shroom family member 2). [provided by Alliance of Genome Resources, Jul 2025] | X | 151392505 | 151553784 | Mouse | 133 | symbol , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1557949 | Shroom3 | shroom family member 3 | Enables actin binding activity. Acts upstream of or within several processes, including columnar/cuboidal epithelial cell development; neural tube closure; and regulation of cell shape. Located in several cellular components, including adherens junction; apical junction complex; and apical plasma me mbrane. Is expressed in several structures, including central nervous system; gut; heart; paraxial mesenchyme; and sensory organ. Orthologous to human SHROOM3 (shroom family member 3). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 92831294 | 93113618 | Mouse | 155 | symbol , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1620640 | Shroom4 | shroom family member 4 | Enables actin filament binding activity and myosin II binding activity. Acts upstream of or within actin filament organization. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and stress fiber. Colocalizes with cortical actin cytoskeleton. Is expresse d in several structures, including brain; genitourinary system; heart; liver; and lung. Orthologous to human SHROOM4 (shroom family member 4). [provided by Alliance of Genome Resources, Jul 2025] | X | 6312012 | 6549508 | Mouse | 93 | symbol , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 10898 | Mip | major intrinsic protein of lens fiber | Enables water channel activity. A structural constituent of eye lens. Acts upstream of or within lens development in camera-type eye; visual perception; and water transport. Located in plasma membrane. Is expressed in several structures, including eye; femur; and main olfactory bulb. Used to study c ataract 15 multiple types. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human MIP (major intrinsic protein of lens fiber). [provided by Alliance of Genome Resources, Apr 2025] | 10 | 128061679 | 128067681 | Mouse | 123 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1624066 | Ttn | titin | Enables ankyrin binding activity. Involved in heart development; regulation of relaxation of cardiac muscle; and somitogenesis. Acts upstream of or within several processes, including forward locomotion; heart development; and sarcomere organization. Located in M band and Z disc. Is expressed in sev eral structures, including alimentary system; embryo mesenchyme; heart; lung; and musculature. Used to study autosomal recessive limb-girdle muscular dystrophy type 2J; dilated cardiomyopathy 1G; and tibial muscular dystrophy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to human TTN (titin). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 76534324 | 76812901 | Mouse | 521 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1609478 | Ajap1 | adherens junction associated protein 1 | Enables protein domain specific binding activity. Predicted to be involved in negative regulation of cell-matrix adhesion; negative regulation of wound healing; and regulation of polarized epithelial cell differentiation. Predicted to be located in basolateral plasma membrane and cell surface. Predi cted to be active in adherens junction; cell-cell contact zone; and cytoplasmic side of plasma membrane. Is expressed in several structures, including adrenal gland; brain; eye; genitourinary system; and spinal cord. Orthologous to human AJAP1 (adherens junctions associated protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 153457678 | 153568313 | Mouse | 111 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
