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Gene: Mip (major intrinsic protein of lens fiber) Mus musculus
Symbol: Mip
Name: major intrinsic protein of lens fiber
RGD ID: 10898
Description: Exhibits water channel activity. Involved in lens development in camera-type eye; visual perception; and water transport. Localizes to plasma membrane. Is expressed in several structures, including eye; femur; and main olfactory bulb. Used to study cataract 15 multiple types. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human MIP (major intrinsic protein of lens fiber); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; acetohydrazide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Aq; Aqp0; aquaporin 0; aquaporin-0; Cat; cataract and small eye; Ct; Cts; dominant cataract; Hfi; hydropic fibers; lens fiber major intrinsic protein; lens opacity; Lop; major intrinsic protein of eye lens fiber; MIP26; MP26; shri; shrivelled; Svl
Homo sapiens (human) : MIP (major intrinsic protein of lens fiber)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mip (major intrinsic protein of lens fiber)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mip (major intrinsic protein of lens fiber)
Pan paniscus (bonobo/pygmy chimpanzee) : MIP (major intrinsic protein of lens fiber)
Canis lupus familiaris (dog) : MIP (major intrinsic protein of lens fiber)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mip (major intrinsic protein of lens fiber)
Sus scrofa (pig) : MIP (major intrinsic protein of lens fiber)
Chlorocebus sabaeus (African green monkey) : MIP (major intrinsic protein of lens fiber)
Heterocephalus glaber (naked mole-rat) : Mip (major intrinsic protein of lens fiber)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl10128,225,838 - 128,231,812 (+)EnsemblGRCm38mm10GRCm38
GRCm3810128,225,810 - 128,231,812 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710127,662,894 - 127,668,867 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610127,628,787 - 127,634,760 (+)NCBImm8
Celera10133,261,918 - 133,267,869 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Mip
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10898
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.