| 1550713 | Ufm1 | ubiquitin-fold modifier 1 | Involved in protein ufmylation and response to endoplasmic reticulum stress. Located in endoplasmic reticulum and nucleus. Is expressed in embryo and pancreas epithelium. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 14. Orthologous to human UFM1 ;'>UFM1 (ubiquitin fold modifier 1). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 53760797 | 53771228 | Mouse | 143 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1319588 | Ufl1 | UFM1 specific ligase 1 | Predicted to enable UFM1 ligase activity and protein kinase binding activity. Involved in several processes, including hemopoiesis; negative regulation of T cell activation; and positive regulation of autophagy. Acts upstream of or within positive regulation of glial cell proliferation; regulation of gene expression; and response to L-glutamate. Located in cytoplasm and neuron projection. Is expressed in cerebellum; cerebral cortex; embryo; and liver. Orthologous to human UFL1 (UFM1 specific ligase 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 25247149 | 25281821 | Mouse | 211 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1623958 | Ufsp1 | UFM1-specific peptidase 1 | Enables deUFMylase activity. Predicted to be involved in protein maturation. Predicted to be active in cytosol. Is expressed in several structures, including diaphragm; limb segment; nervous system; skeletal musculature; and thymus primordium. Orthologous to human UFSP1 (UFM1 ;'>UFM1 specific peptidase 1). [provided by Alliance of Genome Resources, Apr 2025] | 5 | 137292931 | 137293926 | Mouse | 53 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1322473 | Ufsp2 | UFM1-specific peptidase 2 | Enables deUFMylase activity. Involved in regulation of type II interferon production. Located in endoplasmic reticulum and nucleus. Is expressed in liver; orbito-sphenoid; pancreas epithelium; and turbinate bone primordium. Human ortholog(s) of this gene implicated in Beukes hip dysplasia and develo pmental and epileptic encephalopathy 106. Orthologous to human UFSP2 (UFM1 specific peptidase 2). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 46428551 | 46449995 | Mouse | 98 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1323297 | Uba5 | ubiquitin-like modifier activating enzyme 5 | Enables UFM1 activating enzyme activity. Involved in myeloid cell differentiation; protein ufmylation; and regulation of type II interferon production. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol. Is expressed in liver. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 24 and developmental and epileptic encephalopathy 44. Orthologous to human UBA5 (ubiquitin like modifier activating enzyme 5). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 103923786 | 103940767 | Mouse | 160 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1615128 | Ufc1 | ubiquitin-fold modifier conjugating enzyme 1 | Enables UFM1 conjugating enzyme activity. Involved in protein ufmylation and regulation of type II interferon production. Is expressed in chondrocranium and liver. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spasticity and poor growth. Orthologous to human UFC1 (ubiquitin-fold modifier conjugating enzyme 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 171116137 | 171122575 | Mouse | 77 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1557559 | Ddrgk1 | DDRGK domain containing 1 | Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; UFM1-modified protein reader activity; and ubiquitin-like protein ligase binding activity. Involved in several processes, including negative regulation of endoplasm ic reticulum unfolded protein response; positive regulation of plasma cell differentiation; and positive regulation of protein localization to endoplasmic reticulum. Is active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver and biliary system; and nervous system. Orthologous to human DDRGK1 (DDRGK domain containing 1). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 130495955 | 130506549 | Mouse | 166 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1316998 | Zup1 | zinc finger containing ubiquitin peptidase 1 | Predicted to enable cysteine-type deubiquitinase activity and zinc ion binding activity. Predicted to be located in cytosol and nucleoplasm. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZUP1 (zinc finger containing ubiquitin peptidase 1). [provided by Alliance o f Genome Resources, Jul 2025] | 10 | 33795138 | 33827316 | Mouse | 79 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1614357 | Saysd1 | SAYSVFN motif domain containing 1 | Predicted to enable UFM1-modified protein reader activity. Predicted to be involved in protein quality control for misfolded or incompletely synthesized proteins and rescue of stalled ribosome. Is active in endoplasmic reticulum. Orthologous to human SAYSD1 (SAY SVFN motif domain containing 1). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 20125704 | 20133240 | Mouse | 55 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1319807 | Stk38 | serine/threonine kinase 38 | Predicted to enable several functions, including ATP binding activity; UFM1-modified protein reader activity; and magnesium ion binding activity. Predicted to be involved in several processes, including DNA damage checkpoint signaling; negative regulation of MAP kinase activity; and protein phosphorylation. Predicted to be located in cytosol and nucleus. Predicted to be active in glutamatergic synapse and site of double-strand break. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and nose. Orthologous to human STK38 (serine/threonine kinase 38). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 29189854 | 29226979 | Mouse | 194 | description | gene, protein-coding, VALIDATED [RefSeq] |