| 1557826 | Sms | spermine synthase | Predicted to enable spermine synthase activity. Acts upstream of or within spermine metabolic process. Is expressed in several structures, including central nervous system; ganglia; limb; respiratory system; and tooth. Human ortholog(s) of this gene implicated in anxiety disorder and syndromic X-lin ked intellectual disability Snyder type. Orthologous to human SMS (spermine synthase). [provided by Alliance of Genome Resources, Jul 2025] | X | 156226847 | 156275283 | Mouse | 148 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 2298745 | Sms-ps | spermine synthase, pseudogene | | X | 61818734 | 61820243 | Mouse | | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 737192 | Sstr1 | somatostatin receptor 1 | Enables somatostatin receptor activity. Acts upstream of or within cellular response to leukemia inhibitory factor; glutamate receptor signaling pathway; and neuropeptide signaling pathway. Located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; re spiratory system; and sensory organ. Orthologous to human SSTR1 (somatostatin receptor 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 58258524 | 58262822 | Mouse | 123 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1552204 | Sstr2 | somatostatin receptor 2 | The protein encoded by this gene is a receptor for somatostatin, which acts at many sites to inhibit the release of several hormones and other secretory proteins. The encoded protein is a member of the superfamily of receptors having seven transmembrane segments and is involved in many processes, in cluding adenylyl cyclase inhibition, phosphotyrosine phosphatase stimulation, and inhibition of calcium entry and cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] | 11 | 113510153 | 113516854 | Mouse | 198 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1551363 | Sstr3 | somatostatin receptor 3 | Enables signaling receptor binding activity. Predicted to be involved in neuropeptide signaling pathway. Located in ciliary membrane; neuron projection; and non-motile cilium. Is expressed in several structures, including central nervous system; cochlea; gallbladder; genitourinary system; and gut. O rthologous to human SSTR3 (somatostatin receptor 3). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 78421214 | 78433565 | Mouse | 127 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 735551 | Sstr4 | somatostatin receptor 4 | Predicted to enable neuropeptide binding activity and somatostatin receptor activity. Predicted to be involved in several processes, including neuropeptide signaling pathway; positive regulation of arachidonate secretion; and regulation of signal transduction. Predicted to be active in neuron projec tion and plasma membrane. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and sensory organ. Orthologous to human SSTR4 (somatostatin receptor 4). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 148237297 | 148238684 | Mouse | 107 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 736502 | Sstr5 | somatostatin receptor 5 | Predicted to enable neuropeptide binding activity and somatostatin receptor activity. Acts upstream of or within glucose homeostasis and regulation of insulin secretion. Located in plasma membrane. Is expressed in brain; cochlea; cochlear duct epithelium; cochlear ganglion; and organ of Corti. Human ortholog(s) of this gene implicated in bipolar disorder. Orthologous to human SSTR5 (somatostatin receptor 5). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 25708849 | 25716262 | Mouse | 99 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1315070 | Samd8 | sterile alpha motif domain containing 8 | Enables ceramide phosphoethanolamine synthase activity. Acts upstream of or within ceramide biosynthetic process and ceramide phosphoethanolamine biosynthetic process. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be active in Golgi membrane; endoplasmic reticulum membra ne; and plasma membrane. Orthologous to human SAMD8 (sterile alpha motif domain containing 8). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 21800599 | 21848794 | Mouse | 105 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1553375 | Sgms1 | sphingomyelin synthase 1 | Enables ceramide phosphoethanolamine synthase activity and sphingomyelin synthase activity. Involved in sphingomyelin biosynthetic process. Acts upstream of or within ceramide biosynthetic process. Predicted to be located in Golgi trans cisterna. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; ear; limb; and respiratory system. Orthologous to human SGMS1 (sphingomyelin synthase 1). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 32100127 | 32367285 | Mouse | 238 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1331987 | Sgms2 | sphingomyelin synthase 2 | Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthe sis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. [provided by RefSeq, Oct 2008] | 3 | 131112634 | 131197204 | Mouse | 203 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 737256 | Sst | somatostatin | Enables receptor ligand activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels and somatostatin signaling pathway. Acts upstream of or within regulation of cell migration. Located in extracellular space. Is active in GABA-ergic synapse and cytosol. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Orthologous to human SST (somatostatin). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 23708327 | 23710041 | Mouse | 242 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1320988 | Smtn | smoothelin | Predicted to enable actin binding activity. Acts upstream of or within negative regulation of systemic arterial blood pressure and positive regulation of cardiac muscle contraction. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in alimentary system; bladder wall; limb; and musc ulature. Orthologous to human SMTN (smoothelin). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 3467522 | 3489337 | Mouse | 156 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |