| 1323373 | Prc1 | protein regulator of cytokinesis 1 | Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in mitotic spindle midzone assembly; positive regulation of cell population proliferation; and regulation of cytokinesis. Predicted to act upst ream of or within microtubule bundle formation. Predicted to be located in several cellular components, including contractile ring; intercellular bridge; and midbody. Predicted to be active in cytoplasm and mitotic spindle midzone. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 79944224 | 79966007 | Mouse | 271 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1316582 | Bmi1 | Bmi1 polycomb ring finger protot-oncogene | Enables promoter-specific chromatin binding activity and ubiquitin-protein transferase activator activity. Involved in positive regulation of B cell proliferation and positive regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including chordate embr yonic development; negative regulation of macromolecule biosynthetic process; and regulation of adaxial/abaxial pattern formation. Located in heterochromatin and nuclear body. Part of PRC1 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to several human genes including BMI1 (BMI1 proto-oncogene, polycomb ring finger). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 18681953 | 18691440 | Mouse | 443 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1550491 | Cbx7 | chromobox 7 | Enables chromatin binding activity; histone H3K9me2/3 reader activity; and single-stranded RNA binding activity. Acts upstream of or within sebaceous gland development. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in brain. Human or tholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 79800005 | 79855344 | Mouse | 179 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1558087 | Cbx8 | chromobox 8 | Enables single-stranded RNA binding activity and ubiquitin-protein transferase activator activity. Predicted to be involved in positive regulation of cell population proliferation; positive regulation of collagen biosynthetic process; and regulation of nucleobase-containing compound metabolic proces s. Predicted to act upstream of or within heterochromatin formation. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in several structures, including brain. Orthologous to human CBX8 (chromobox 8). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 118929262 | 118931739 | Mouse | 113 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1550113 | Pcgf2 | polycomb group ring finger 2 | Enables chromatin binding activity. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; chordate embryonic development; and negative regulation of transcription by RNA polymerase II. Located in nuclear body and sex chromatin. Part of PRC1 ht:700;'>PRC1 complex. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; eye; and genitourinary system. Orthologous to human PCGF2 (polycomb group ring finger 2). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 97579647 | 97593260 | Mouse | 197 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1317381 | Phc2 | polyhomeotic 2 | Predicted to enable chromatin binding activity; histone binding activity; and identical protein binding activity. Acts upstream of or within spermatogenesis. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in several structures, includ ing central nervous system and retina nuclear layer. Orthologous to human PHC2 (polyhomeotic homolog 2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 128548448 | 128646674 | Mouse | 165 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1332085 | Ring1 | ring finger protein 1 | Enables chromatin binding activity and ubiquitin-protein transferase activator activity. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within anterior/posterior pattern specification; camera-type eye morphogenesis; and negative regulation of DNA-tem plated transcription. Located in nuclear body and sex chromatin. Part of PRC1 complex. Is expressed in several structures, including central nervous system; epithelium; hemolymphoid system; reproductive system; and urinary system. Orthologous to human RING1 (ring finger protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 34239766 | 34243654 | Mouse | 118 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1313549 | Rnf2 | ring finger protein 2 | Enables chromatin binding activity and histone H2AK119 ubiquitin ligase activity. Involved in germ cell development and negative regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within with a negative e ffect on gene expression. Acts upstream of or within anterior/posterior axis specification; gastrulation with mouth forming second; and mitotic cell cycle. Located in euchromatin; nuclear body; and sex chromatin. Part of PRC1 complex. Is active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; limb; and retina. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome. Orthologous to human RNF2 (ring finger protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 151345159 | 151376562 | Mouse | 201 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1616550 | Samd11 | sterile alpha motif domain containing 11 | Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and protein domain specific binding activity. Involved in retinal rod cell development. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of PRC1 complex. Is expressed in photoreceptor layer; pineal gland; retina; retina layer; and retina outer nuclear layer. Orthologous to human SAMD11 (sterile alpha motif domain containing 11). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 156331423 | 156342409 | Mouse | 85 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1553081 | Samd7 | sterile alpha motif domain containing 7 | Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of gene expression, epigenetic and retinal rod cell development. Located in cytoplasm and nucleus. Part of PRC1 complex. Is expressed in central ner vous system; dorsal root ganglion; liver; metanephros; and neural retina. Human ortholog(s) of this gene implicated in macular degeneration. Orthologous to human SAMD7 (sterile alpha motif domain containing 7). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 30800481 | 30821323 | Mouse | 39 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1619223 | Suz12 | SUZ12 polycomb repressive complex 2 subunit | This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009] | 11 | 79883932 | 79924949 | Mouse | 233 | description | gene, protein-coding, REVIEWED [RefSeq] |
