| 730947 | Crh | corticotropin releasing hormone | This gene encodes a member of the corticotropin-releasing factor family and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is a neuropeptide hormone that binds to the corticotropin releasing hormone receptors (CRH >CRHR1 and CRHR2) to stimulate the release of adrenocorticotropic hormone from the pituitary gland in response to stress. The encoded protein may also regulate angiogenesis and inflammation. Homozygous knockout mice for this gene exhibit reduced corticosterone levels while the offspring of these mice die perinatally. [provided by RefSeq, Aug 2015] | 3 | 19747565 | 19749560 | Mouse | 534 | symbol , PhenoGen , description | gene, protein-coding, REVIEWED [RefSeq] |
| 730852 | Crhbp | corticotropin releasing hormone binding protein | Enables corticotropin-releasing hormone binding activity. Involved in several processes, including cellular response to cAMP; cellular response to estradiol stimulus; and cellular response to gonadotropin-releasing hormone. Acts upstream of or within hormone metabolic process. Located in extracellul ar space and nucleus. Is expressed in adrenal gland; central nervous system; eye; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in depressive disorder and opioid abuse. Orthologous to human CRHBP (corticotropin releasing hormone binding protein). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 95567884 | 95581339 | Mouse | 194 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 733139 | Crhr2 | corticotropin releasing hormone receptor 2 | Enables corticotrophin-releasing factor receptor activity and hormone activity. Acts upstream of or within G protein-coupled receptor signaling pathway and negative regulation of angiogenesis. Predicted to be located in cell body fiber; perikaryon; and varicosity. Predicted to be active in axon term inus; dendrite; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 55067033 | 55110001 | Mouse | 220 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737026 | Crhr1 | corticotropin releasing hormone receptor 1 | The protein encoded by this gene is a G-protein coupled receptor that binds corticotropin-releasing factor (CRH) and urocortin (UCN) with high affinity. The encoded protein upregulates adenylate cyclase activity and intracellular cAMP levels. This protein is ess ential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response, and obesity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] | 11 | 104021289 | 104066349 | Mouse | 289 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1614474 | Crip1 | cysteine-rich protein 1 | Predicted to enable peptide binding activity and zinc ion binding activity. Predicted to be involved in several processes, including cellular response to UV-B; intrinsic apoptotic signaling pathway in response to DNA damage; and response to zinc ion. Predicted to be located in cytoplasm. Is expresse d in several structures, including genitourinary system; gut; hemolymphoid system gland; integumental system; and limb segment. Orthologous to human CRIP1 (cysteine rich protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 113115632 | 113117499 | Mouse | 148 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1332093 | Carhsp1 | calcium regulated heat stable protein 1 | Predicted to enable mRNA 3'-UTR binding activity. Involved in regulation of mRNA stability. Located in P granule and cytosol. Part of cytoplasmic exosome (RNase complex). Is expressed in dorsal root ganglion; genitourinary system; limb; neural tube; and telencephalon. Orthologous to human CARHSP1 (c alcium regulated heat stable protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 8476444 | 8490017 | Mouse | 160 | old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |