| 1348902 | SSB | small RNA binding exonuclease protection factor La | The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RN As associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014] | 2 | 169798871 | 169812064 | Human | 138 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1604788 | SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | Enables ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 9292894 | 9369532 | Human | 173 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1603193 | SPSB2 | splA/ryanodine receptor domain and SOCS box containing 2 | | 12 | 6875764 | 6889358 | Human | | old_gene_name , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1603370 | SPSB4 | splA/ryanodine receptor domain and SOCS box containing 4 | Enables ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including positive regulation of protein polyubiquitination; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 141051347 | 141148611 | Human | 131 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 736464 | SSBP1 | single stranded DNA binding protein 1 | SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501 ].[supplied by OMIM, Feb 2010] | 7 | 141738321 | 141750488 | Human | 175 | symbol , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16556661 | SSBL2P | SSB like 2, pseudogene | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
| 16554858 | SSBL4P | SSB like 4, pseudogene | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
| 16562243 | AC009268.1 | Sjogren syndrome antigen B (autoantigen La) (SSB) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16555961 | AL161449.1 | Sjogren syndrome antigen B (autoantigen La) (SSB) pseudogene | | 9 | 13021476 | 13049754 | Human | | name | gene, pseudo, MODEL [RefSeq] |
| 27095971 | SSBL2P | small RNA binding exonuclease protection factor La like 2, pseudogene | | X | 62779133 | 62780626 | Human | | symbol , GTEx , old_gene_name , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 27095977 | SSBL3P | small RNA binding exonuclease protection factor La like 3, pseudogene | | 12 | 45071774 | 45073035 | Human | | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 27095978 | SSBL4P | small RNA binding exonuclease protection factor La like 4, pseudogene | | 1 | 147082034 | 147083650 | Human | | symbol , GTEx , old_gene_name , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 27095972 | SSBL5P | small RNA binding exonuclease protection factor La like 5, pseudogene | | 7 | 12471342 | 12472826 | Human | | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1317489 | INIP | INTS3 and NABP interacting protein | The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016] | 9 | 112683926 | 112718117 | Human | 76 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 35315959 | SPSB2 | splA/ryanodine receptor domain and SOCS box containing 2 | This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] | 12 | 6870935 | 6873303 | Human | 90 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1603939 | SPSB3 | splA/ryanodine receptor domain and SOCS box containing 3 | Enables ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including negative regulation of cGAS/STING signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein K48-linked ubiquitination. Part of Cul5-RING ubiquitin ligase complex. Is a ctive in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 1776712 | 1782571 | Human | 81 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16557889 | SSBL6P | small RNA binding exonuclease protection factor La like 6, pseudogene | | | | | Human | | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, processed_pseudogene |
| 1344325 | SSBP2 | single stranded DNA binding protein 2 | This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human gliobl astoma patients. [provided by RefSeq, Sep 2016] | 5 | 81412804 | 81751807 | Human | 138 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 731988 | SSBP3 | single stranded DNA binding protein 3 | Predicted to enable single-stranded DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be part of transc ription regulator complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 54225432 | 54413490 | Human | 125 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1350792 | SSBP4 | single stranded DNA binding protein 4 | Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 18402725 | 18434562 | Human | 84 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 155783003 | SSBL6P | small RNA binding exonuclease protection factor La like 6, pseudogene | | 3 | 166293756 | 166294353 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 625776950 | SSBP1P1 | SSBP1 pseudogene 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 625776956 | SSBP1P2 | SSBP1 pseudogene 2 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 625776953 | SSBP1P3 | SSBP1 pseudogene 3 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo |
| 625776963 | SSBP1P4 | SSBP1 pseudogene 4 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 14995371 | SSBP3P1 | SSBP3 pseudogene 1 | | 7 | 39833371 | 39834915 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 14995388 | SSBP3P2 | SSBP3 pseudogene 2 | | 2 | 131351886 | 131353438 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16552064 | SSBP3P3 | SSBP3 pseudogene 3 | | 22 | 15572087 | 15573263 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16561410 | SSBP3P4 | SSBP3 pseudogene 4 | | 14 | 18645045 | 18646221 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16561448 | SSBP3P5 | SSBP3 pseudogene 5 | | 14 | 19668829 | 19670000 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16552289 | SSBP3P6 | SSBP3 pseudogene 6 | | 2 | 129992889 | 129994037 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7246238 | SSBP3-AS1 | SSBP3 antisense RNA 1 | Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 54236443 | 54239063 | Human | 6 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 616336040 | SSBP3-AS2 | SSBP3 antisense RNA 2 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 1603967 | NABP1 | nucleic acid binding protein 1 | Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008] | 2 | 191678136 | 191686943 | Human | 239 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1601970 | NABP2 | nucleic acid binding protein 2 | Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008] | 12 | 56222015 | 56229854 | Human | 88 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1351802 | KIR2DL1 | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | 19 | 54769793 | 54784322 | Human | 29 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1347662 | KIR2DL2 | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | | | | Human | 23 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1351159 | KIR2DL3 | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | 19 | 54738513 | 54753052 | Human | 35 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1353116 | KIR2DL4 | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016] | 19 | 54803610 | 54814517 | Human | 37 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1607012 | KIR2DL5A | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | | | | Human | 11 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1347492 | KIR2DS1 | killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | | | | Human | 18 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1344459 | KIR2DS2 | killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene represents a haplotype-specific family member that encodes a protein with a short cytoplasmic tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] | | | | Human | 19 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1348050 | KIR2DS4 | killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 (gene/pseudogene) | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | 19 | 54832707 | 54848575 | Human | 21 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1345824 | KIR2DS5 | killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | | | | Human | 21 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 735895 | KIR3DL1 | killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | 19 | 54816468 | 54830778 | Human | 51 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1343393 | KIR3DL2 | killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011] | 19 | 54850443 | 54867207 | Human | 24 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1352085 | KIR3DL3 | killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. [provided by RefSeq, Jul 2008] | 19 | 54724442 | 54736632 | Human | 24 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1352429 | RNY1 | RNA, Ro60-associated Y1 | Y RNAs are small noncoding RNAs that were originally identified as the RNA component of soluble ribonucleoproteins (RNPs) termed Ro RNPs. Ro RNPs are detected by autoimmune sera of patients suffering from rheumatic diseases, such as from systemic lupus erythematosus (MIM 152700) and Sjogren syndrome (MIM 270200). Ro RNPs consist of a Y RNA that is associated with the autoimmune antigen proteins Ro60 (TROVE2; MIM 600063) and La (SSB; MIM 109090), as well as other proteins. Four human Y RNAs have been identified: Y1, Y3 (RNY3; MIM 601822), Y4 (RNY4; MIM 601823), and Y5 (RNY5; MIM 601824). (Y2 is a truncated form of Y1.) Y RNAs are transcribed by RNA polymerase III and range in size from 83 to 112 nucleotides. They appear to have a functional role in chromosomal DNA replication (Christov et al., 2006 [PubMed 16943439]).[supplied by OMIM, Apr 2009] | 7 | 148987136 | 148987248 | Human | 9 | description | gene, ncrna, PROVISIONAL [RefSeq] |
| 16555349 | AL357134.1 | single-stranded DNA binding protein (SSBP1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16555560 | AC004987.2 | single stranded DNA binding protein 3 (SSBP3) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16552241 | AL024474.1 | single-stranded DNA binding protein 1 (SSBP1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16564692 | AP002414.4 | single stranded DNA binding protein 4 (SSBP4) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16557009 | AL353093.1 | single-stranded DNA binding protein (SSBP1)(SSBP) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16554206 | AC016909.1 | pseudogene similar to part of single-stranded DNA binding protein 1 (SSBP1) | | | | | Human | | name | gene, processed_pseudogene |
