Men1 Gene Search Result

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4 records found for search term Men1

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
736443	MEN1	menin 1	This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin struc ... (more) ture through the modification of histones. [provided by RefSeq, May 2019]	11	64803516	64811294	Human	1279	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1346504	SF1	splicing factor 1	This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role ... (more) in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]	11	64764606	64778542	Human	176	old_gene_name	gene, protein-coding, REVIEWED [RefSeq]
1350269	ZFPL1	zinc finger protein like 1	Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]	11	65084222	65088398	Human	56	old_gene_name	gene, protein-coding, VALIDATED [RefSeq]
69115	CDKN1B	cyclin dependent kinase inhibitor 1B	This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this pr ... (more) otein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]	12	12717368	12722369	Human	1166	old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]