| 730881 | HRAS | HRas proto-oncogene, GTPase | This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protei n undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008] | 11 | 532242 | 535576 | Human | 936 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1319850 | PLAAT1 | phospholipase A and acyltransferase 1 | Enables acyltransferase activity, transferring groups other than amino-acyl groups and phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process and phosphatidylcholine metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025 ] | 3 | 193240606 | 193281426 | Human | 105 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737532 | PLAAT3 | phospholipase A and acyltransferase 3 | Enables N-acyltransferase activity; lipid binding activity; and phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process. Predicted to be located in several cellular components, including lysosome; nuclear envelope; and peroxisome. Predicted to be active in cytoplasm. Bio marker of seminoma. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 63574462 | 63616927 | Human | 264 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1344464 | PLAAT2 | phospholipase A and acyltransferase 2 | The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethano lamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016] | 11 | 63552770 | 63565070 | Human | 45 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1342575 | PLAAT4 | phospholipase A and acyltransferase 4 | Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone rece ptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008] | 11 | 63536808 | 63546458 | Human | 97 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1606473 | PLAAT5 | phospholipase A and acyltransferase 5 | Enables N-acyltransferase activity; phospholipase A1 activity; and phospholipase A2 activity. Acts upstream of or within N-acylphosphatidylethanolamine metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 63461404 | 63491167 | Human | 62 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1345319 | ERAS | ES cell expressed Ras | This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and c hemotherapy resistance. [provided by RefSeq, Dec 2012] | X | 48826513 | 48829869 | Human | 31 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1314751 | RASSF7 | Ras association domain family member 7 | Predicted to be involved in apoptotic process and signal transduction. Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 560970 | 564025 | Human | 78 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 69137 | RASGRP1 | RAS guanyl releasing protein 1 | This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activat es the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008] | 15 | 38488103 | 38564814 | Human | 265 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1321350 | DIRAS1 | DIRAS family GTPase 1 | DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004] | 19 | 2714567 | 2721372 | Human | 73 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1313693 | DIRAS2 | DIRAS family GTPase 2 | DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004] | 9 | 90609832 | 90642824 | Human | 81 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 735722 | RAB10 | RAB10, member RAS oncogene family | RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009] | 2 | 26033285 | 26137454 | Human | 193 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 737281 | RALBP1 | ralA binding protein 1 | RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RA LGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010] | 18 | 9475009 | 9538114 | Human | 180 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1315047 | RAPGEF2 | Rap guanine nucleotide exchange factor 2 | Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS a ctivators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] | 4 | 159103079 | 159360173 | Human | 218 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1343059 | RAPGEF5 | Rap guanine nucleotide exchange factor 5 | Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS a ctivators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] | 7 | 22118236 | 22357154 | Human | 114 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1312152 | RASGRP3 | RAS guanyl releasing protein 3 | The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017] | 2 | 33436348 | 33564731 | Human | 142 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1316971 | RIT2 | Ras like without CAAX 2 | RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008] | 18 | 42743227 | 43115685 | Human | 109 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1348132 | ZDHHC9 | zDHHC palmitoyltransferase 9 | This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS ;'>HRAS and NRAS. Mutations in this gene are associated with X-linked cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010] | X | 129803288 | 129843886 | Human | 172 | description | gene, protein-coding, REVIEWED [RefSeq] |
