| 736253 | HDC | histidine decarboxylase | This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscl e tone.[provided by RefSeq, Aug 2010] | 15 | 50241947 | 50265726 | Human | 256 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1312483 | HECA | hdc homolog, cell cycle regulator | This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during trach eal development. [provided by RefSeq, Jul 2008] | 6 | 139135080 | 139180802 | Human | 84 | name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1320216 | CD209 | CD209 molecule | This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viru ses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020] | 19 | 7739993 | 7747534 | Human | 122 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1321334 | DCSTAMP | dendrocyte expressed seven transmembrane protein | This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing r esults in multiple transcript variants. [provided by RefSeq, Mar 2012] | 8 | 104339796 | 104356689 | Human | 94 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1602812 | DGAT2L6 | diacylglycerol O-acyltransferase 2 like 6 | This gene is a member of the diacylglycerol acyltransferase 2 family. The encoded protein is a putative acyltransferase and is most likely involved in the synthesis of di- or triacylglycerol, however its substrate specificity is currently unknown. [provided by RefSeq, Feb 2015] | X | 70177483 | 70205704 | Human | 28 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1323209 | MOGAT1 | monoacylglycerol O-acyltransferase 1 | Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM, Mar 2008] | 2 | 222671658 | 222709930 | Human | 116 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1316028 | MOGAT2 | monoacylglycerol O-acyltransferase 2 | The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the e ndoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015] | 11 | 75717838 | 75732953 | Human | 99 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1350436 | MOGAT3 | monoacylglycerol O-acyltransferase 3 | Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM, Mar 2008] | 7 | 101192886 | 101201036 | Human | 47 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1352867 | CLEC4A | C-type lectin domain family 4 member A | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The enco ded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] | 12 | 8102907 | 8138607 | Human | 115 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1345966 | SLC25A47 | solute carrier family 25 member 47 | This gene encodes a member of a large family of mitochondrial transporters. The nuclear-encoded carrier protein is embedded in the inner mitochondrial membrane. This member of the family is thought to be an uncoupling protein that uncouples mitochondrial respiration from ATP synthesis by dissipating the transmembrane proton gradient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017] | 14 | 100323339 | 100330421 | Human | 89 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1348381 | DCP1B | decapping mRNA 1B | This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [pr ovided by RefSeq, Feb 2016] | 12 | 1941591 | 2004457 | Human | 83 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1604373 | DSTYK | dual serine/threonine and tyrosine protein kinase | This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] | 1 | 205142505 | 205211702 | Human | 151 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1314468 | ESF1 | ESF1 nucleolar pre-rRNA processing protein | Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025] | 20 | 13714325 | 13784919 | Human | 79 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1320090 | KMT2E | lysine methyltransferase 2E (inactive) | This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [p rovided by RefSeq, Jul 2008] | 7 | 105014205 | 105115019 | Human | 202 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1604813 | LARP7 | La ribonucleoprotein 7, transcriptional regulator | This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudoge ne of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012] | 4 | 112637143 | 112657586 | Human | 194 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1315499 | MRPS35 | mitochondrial ribosomal protein S35 | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryot ic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010] | 12 | 27710832 | 27756295 | Human | 80 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1315944 | MS4A4A | membrane spanning 4-domains A4A | This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spli ced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] | 11 | 60280666 | 60308970 | Human | 51 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1320353 | NUDT4 | nudix hydrolase 4 | The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates ma y contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008] | 12 | 93377925 | 93408146 | Human | 162 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1322302 | PPIL4 | peptidylprolyl isomerase like 4 | This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008] | 6 | 149504495 | 149546043 | Human | 84 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1312554 | PSMG2 | proteasome assembly chaperone 2 | Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Located in nucleus. Part of protein folding chaperone complex. Implicated in proteosome-associated autoinflammatory syndrome 4. [provided by Alliance of Genome Resources, Jul 2025] | 18 | 12658738 | 12725740 | Human | 109 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1350050 | DCP1A | decapping mRNA 1A | Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature te rmination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014] | 3 | 53283429 | 53347543 | Human | 112 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
