Csk Gene Search Result

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6 records found for search term Csk

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1318780	CSK	C-terminal Src kinase	The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein al ... (more) so phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]	15	74782080	74803197	Human	219	symbol , old_gene_name , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1604451	SCIMP	SLP adaptor and CSK interacting membrane protein	This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript ... (more) variants have been found for this gene. [provided by RefSeq, Dec 2012]	17	5208920	5234860	Human	81	old_gene_name , name	gene, protein-coding, REVIEWED [RefSeq]
1603638	PAG1	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]	8	80967810	81112068	Human	117	old_gene_name , description	gene, protein-coding, REVIEWED [RefSeq]
69108	MATK	megakaryocyte-associated tyrosine kinase	The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack ... (more) of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]	19	3777973	3801799	Human	113	old_gene_name , description	gene, protein-coding, REVIEWED [RefSeq]
2304141	CSKMT	citrate synthase lysine methyltransferase	Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; and peptidyl-lysine trimethylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]	11	62665312	62668108	Human	30	symbol , old_gene_name , COSMIC , Human Proteome Map	gene, protein-coding, VALIDATED [RefSeq]
1347139	CSNK2B	casein kinase 2 beta	This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alp ... (more) ha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]	6	31666080	31670067	Human	243	old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]