| 1303222 | Aicda | activation-induced cytidine deaminase | ENCODES a protein that exhibits cytidine deaminase activity (ortholog); identical protein binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to bacterium (ortholog); isotype switching (ortholog); PARTICIPA TES IN interleukin-4 signaling pathway; primary immunodeficiency pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Alphavirus Infections (ortholog); autoimmune disease (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-containing complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol | 4 | 157446120 | 157455958 | Rat | 142 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1347771 | AICDA | activation induced cytidine deaminase | This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. AICDA is specifically expressed and active in germinal center-like B cells. In the germinal center, AICDA is involved in somatic hy permutation, gene conversion, and class-switch recombination of immunoglobulin genes. An epigenetic role in neoplastic transformation and lymphoma progression has been experimentally ascribed to AICDA using mouse models. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Jul 2020] | 12 | 8602170 | 8612859 | Human | 206 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551301 | Aicda | activation-induced cytidine deaminase | Enables cytidine deaminase activity. Involved in cytidine deamination and isotype switching. Acts upstream of or within cellular response to lipopolysaccharide and defense response to bacterium. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in P-body and nucleus. Is expressed in several structures, including immune system; lower urogenital tract; lung; reproductive system; and urethra epithelium. Used to study immunodeficiency with hyper-IgM type 2. Human ortholog(s) of this gene implicated in hyperimmunoglobulin syndrome and immunodeficiency with hyper-IgM type 2. Orthologous to human AICDA (activation induced cytidine deaminase). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 122530768 | 122541139 | Mouse | 221 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 11771988 | AICDA | activation induced cytidine deaminase | ENCODES a protein that exhibits catalytic activity (inferred); cytidine deaminase activity (inferred); hydrolase activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to bacterium (ortholog); isotype switching (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Alphavirus Infections (ortholog); autoimmune disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred) | 12 | 8688392 | 8699008 | Bonobo | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12239783 | AICDA | activation induced cytidine deaminase | ENCODES a protein that exhibits cytidine deaminase activity (ortholog); identical protein binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to bacterium (ortholog); isotype switching (ortholog); PARTICIPA TES IN interleukin-4 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Alphavirus Infections (ortholog); autoimmune disease (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-containing complex (ortholog) | 27 | 37064107 | 37073791 | Dog | 88 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12596425 | Aicda | activation induced cytidine deaminase | ENCODES a protein that exhibits catalytic activity (inferred); cytidine deaminase activity (inferred); hydrolase activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to bacterium (ortholog); isotype switching (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Alphavirus Infections (ortholog); autoimmune disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred) | NW_004936870 | 25039 | 34601 | Squirrel | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934249 | Aicda | activation induced cytidine deaminase | ENCODES a protein that exhibits identical protein binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to bacterium (ortholog); isotype switching (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Alphavirus Infections (ortholog); autoimmune disease (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Naked Mole-Rat | 84 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626079229 | Aicda | activation induced cytidine deaminase | ENCODES a protein that exhibits cytidine deaminase activity (ortholog); identical protein binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to bacterium (ortholog); isotype switching (ortholog); PARTICIPA TES IN interleukin-4 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Alphavirus Infections (ortholog); autoimmune disease (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-containing complex (ortholog) | | | | Black Rat | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14207846 | AICDA | activation induced cytidine deaminase | ENCODES a protein that exhibits catalytic activity (inferred); cytidine deaminase activity (inferred); hydrolase activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to bacterium (ortholog); isotype switching (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Alphavirus Infections (ortholog); autoimmune disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); protein-containing complex (inferred) | | | | Pig | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18430293 | AICDA | activation induced cytidine deaminase | ENCODES a protein that exhibits catalytic activity (inferred); cytidine deaminase activity (inferred); hydrolase activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to bacterium (ortholog); isotype switching (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Alphavirus Infections (ortholog); autoimmune disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred) | | | | Green Monkey | 91 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247280 | aicda | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155239970 | aicda.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155240359 | aicda.S | | | | | | African Clawed Frog | | symbol | gene, null |