| 1348132 | ZDHHC9 | zDHHC palmitoyltransferase 9 | This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010] | X | 129803288 | 129843886 | Human | 172 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1556934 | Zdhhc9 | zinc finger, DHHC domain containing 9 | Predicted to enable Ras palmitoyltransferase activity. Involved in positive regulation of pyroptotic inflammatory response. Acts upstream of or within non-canonical inflammasome complex assembly and protein maturation. Predicted to be located in Golgi membrane and cytosol. Predicted to be part of pa lmitoyltransferase complex. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in cerebral cortex ventricular layer and cortical plate. Used to study syndromic X-linked intellectual disability Raymond type. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Raymond type. Orthologous to human ZDHHC9 (zinc finger DHHC-type palmitoyltransferase 9). [provided by Alliance of Genome Resources, Apr 2025] | X | 47260844 | 47297792 | Mouse | 136 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1561389 | Zdhhc9 | zDHHC palmitoyltransferase 9 | ENCODES a protein that exhibits palmitoyltransferase activity (ortholog); protein-cysteine S-palmitoyltransferase activity (ortholog); Ras palmitoyltransferase activity (ortholog); INVOLVED IN peptidyl-L-cysteine S-palmitoylation (ortholog); positive regulation of cGAS/STING signaling pathway (ortho log); positive regulation of pyroptotic inflammatory response (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); Golgi apparatus (ortholog); INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; bisphenol A | X | 132230243 | 132266139 | Rat | 105 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8930089 | Zdhhc9 | zDHHC palmitoyltransferase 9 | ENCODES a protein that exhibits palmitoyltransferase activity (ortholog); protein-cysteine S-palmitoyltransferase activity (ortholog); Ras palmitoyltransferase activity (ortholog); INVOLVED IN peptidyl-L-cysteine S-palmitoylation (ortholog); positive regulation of cGAS/STING signaling pathway (ortho log); positive regulation of pyroptotic inflammatory response (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); Golgi apparatus (ortholog) | NW_004955473 | 5174575 | 5208767 | Chinchilla | 22 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11685150 | ZDHHC9 | zDHHC palmitoyltransferase 9 | ENCODES a protein that exhibits acyltransferase activity (inferred); palmitoyltransferase activity (inferred); protein-cysteine S-palmitoyltransferase activity (inferred); INVOLVED IN peptidyl-L-cysteine S-palmitoylation (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); genetic diseas e (ortholog); intellectual disability (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); Golgi apparatus (inferred) | X | 118932986 | 118973238 | Bonobo | 32 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12378763 | ZDHHC9 | zinc finger DHHC-type palmitoyltransferase 9 | ENCODES a protein that exhibits acyltransferase activity (inferred); palmitoyltransferase activity (inferred); protein-cysteine S-palmitoyltransferase activity (inferred); INVOLVED IN peptidyl-L-cysteine S-palmitoylation (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); genetic diseas e (ortholog); intellectual disability (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); Golgi apparatus (inferred) | X | 101011072 | 101096394 | Dog | 31 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12734336 | Zdhhc9 | zDHHC palmitoyltransferase 9 | ENCODES a protein that exhibits acyltransferase activity (inferred); palmitoyltransferase activity (inferred); protein-cysteine S-palmitoyltransferase activity (inferred); INVOLVED IN peptidyl-L-cysteine S-palmitoylation (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); genetic diseas e (ortholog); intellectual disability (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); Golgi apparatus (inferred) | NW_004936479 | 1711756 | 1743306 | Squirrel | 32 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625839463 | Zdhhc9 | zDHHC palmitoyltransferase 9 | ENCODES a protein that exhibits palmitoyltransferase activity (ortholog); protein-cysteine S-palmitoyltransferase activity (ortholog); Ras palmitoyltransferase activity (ortholog); INVOLVED IN peptidyl-L-cysteine S-palmitoylation (ortholog); positive regulation of cGAS/STING signaling pathway (ortho log); positive regulation of pyroptotic inflammatory response (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); Golgi apparatus (ortholog) | | | | Black Rat | 22 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13996158 | ZDHHC9 | zinc finger DHHC-type palmitoyltransferase 9 | ENCODES a protein that exhibits acyltransferase activity (inferred); palmitoyltransferase activity (inferred); protein-cysteine S-palmitoyltransferase activity (inferred); INVOLVED IN peptidyl-L-cysteine S-palmitoylation (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); genetic diseas e (ortholog); intellectual disability (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); Golgi apparatus (inferred) | | | | Pig | 31 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 20866446 | ZDHHC9 | zinc finger DHHC-type palmitoyltransferase 9 | ENCODES a protein that exhibits acyltransferase activity (inferred); palmitoyltransferase activity (inferred); protein-cysteine S-palmitoyltransferase activity (inferred); INVOLVED IN host-mediated activation of viral process (inferred); positive regulation of cGAS/STING signaling pathway (inferred) ; positive regulation of pyroptotic inflammatory response (inferred); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); Golgi apparatus (inferred) | | | | Green Monkey | 24 | symbol | gene, protein-coding |
| 18926212 | Zdhhc9 | zDHHC palmitoyltransferase 9 | ENCODES a protein that exhibits acyltransferase activity (inferred); palmitoyltransferase activity (inferred); protein-cysteine S-palmitoyltransferase activity (inferred); INVOLVED IN peptidyl-L-cysteine S-palmitoylation (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); genetic diseas e (ortholog); intellectual disability (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); Golgi apparatus (inferred) | | | | Naked Mole-Rat | 32 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18414103 | ZDHHC9 | zDHHC palmitoyltransferase 9 | ENCODES a protein that exhibits palmitoyltransferase activity (ortholog); protein-cysteine S-palmitoyltransferase activity (ortholog); Ras palmitoyltransferase activity (ortholog); INVOLVED IN peptidyl-L-cysteine S-palmitoylation (ortholog); positive regulation of cGAS/STING signaling pathway (ortho log); positive regulation of pyroptotic inflammatory response (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); Golgi apparatus (ortholog) | | | | Green Monkey | 22 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155256376 | zdhhc9 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155258026 | zdhhc9.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862867 | zdhhc9.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856220 | zdhhc9.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626176773 | zdhhc9.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861416 | zdhhc9.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865461 | zdhhc9.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 735648 | NRAS | NRAS proto-oncogene, GTPase | This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsi c GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011] | 1 | 114704469 | 114716771 | Human | 658 | description | gene, protein-coding, REVIEWED [RefSeq] |