| 621346 | Wnt2 | Wnt family member 2 | ENCODES a protein that exhibits cytokine activity (ortholog); frizzled binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN lung development; positive regulation of endothelial cell proliferation; atrial cardiac muscle tissue morphogenesis (ortholog); PARTICIPATES IN Wnt signaling pa thway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; ASSOCIATED WITH Experimental Seizures; autistic disorder (ortholog); breast cancer (ortholog); FOUND IN cytoplasm (ortholog); extracellular matrix (ortholog); extracellular region (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 4 | 47294300 | 47340284 | Rat | 157 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 736431 | WNT2 | Wnt family member 2 | This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryo genesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008] | 7 | 117275451 | 117323058 | Human | 180 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736432 | Wnt2 | wingless-type MMTV integration site family, member 2 | Predicted to enable cytokine activity and frizzled binding activity. Involved in cell proliferation in midbrain and positive regulation of neurogenesis. Acts upstream of or within several processes, including circulatory system development; lung induction; and positive regulation of cell population proliferation. Predicted to be located in collagen-containing extracellular matrix; cytoplasm; and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including embryo mesenchyme; heart and pericardium; reproductive system; upper jaw primordium; and urethra. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 17988939 | 18032771 | Mouse | 198 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8819659 | Wnt2 | Wnt family member 2 | ENCODES a protein that exhibits cytokine activity (ortholog); frizzled binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN atrial cardiac muscle tissue morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PART ICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autistic disorder (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN cytoplasm (ortholog); extracellular matrix (ortholog); extracellular region (ortholog) | NW_004955432 | 22988208 | 23024530 | Chinchilla | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11811142 | WNT2 | Wnt family member 2 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); receptor ligand activity (inferred); INVOLVED IN atrial cardiac muscle tissue morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PART ICIPATES IN Wnt signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autistic disorder (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular region (inferred) | 7 | 109244772 | 109291472 | Bonobo | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12115078 | WNT2 | Wnt family member 2 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); receptor ligand activity (inferred); INVOLVED IN atrial cardiac muscle tissue morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PART ICIPATES IN Wnt signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autistic disorder (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular region (inferred) | 14 | 56123735 | 56172113 | Dog | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12717890 | Wnt2 | Wnt family member 2 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); receptor ligand activity (inferred); INVOLVED IN atrial cardiac muscle tissue morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PART ICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autistic disorder (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular region (inferred) | NW_004936589 | 1825209 | 1866898 | Squirrel | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13980284 | WNT2 | Wnt family member 2 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); receptor ligand activity (inferred); INVOLVED IN atrial cardiac muscle tissue morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PART ICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autistic disorder (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular region (inferred) | | | | Pig | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14389765 | Wnt2 | | | | | | Fly | | symbol | gene, null |
| 18651399 | WNT2 | Wnt family member 2 | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); receptor ligand activity (inferred); INVOLVED IN atrial cardiac muscle tissue morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PART ICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autistic disorder (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular region (inferred) | | | | Green Monkey | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929442 | Wnt2 | Wnt family member 2 | ENCODES a protein that exhibits receptor ligand activity (ortholog); INVOLVED IN atrial cardiac muscle tissue morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling pathway; W nt signaling, canonical pathway; ASSOCIATED WITH autistic disorder (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN cytoplasm (ortholog); extracellular matrix (ortholog) | | | | Naked Mole-Rat | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 286644735 | wnt2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626066119 | Wnt2 | Wnt family member 2 | ENCODES a protein that exhibits cytokine activity (ortholog); frizzled binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN atrial cardiac muscle tissue morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PART ICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autistic disorder (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN cytoplasm (ortholog); extracellular matrix (ortholog); extracellular region (ortholog) | | | | Black Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285578587 | wnt2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856574 | wnt2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856819 | wnt2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860061 | wnt2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863560 | wnt2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359339 | wnt2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359509 | wnt2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359608 | wnt2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 69346 | Wnt2b | Wnt family member 2B | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN canonical Wnt signaling pathway (ortholog); cellular response to starvation (ortholog); chondrocyte differentiation (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carci noma pathway; ASSOCIATED WITH Diarrhea 9 (ortholog); endodermal sinus tumor (ortholog); Failure to Thrive (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil | 2 | 195142573 | 195156945 | Rat | 138 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733303 | WNT2B | Wnt family member 2B | This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] | 1 | 112466541 | 112530165 | Human | 152 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733304 | Wnt2b | wingless-type MMTV integration site family, member 2B | Predicted to enable cytokine activity and frizzled binding activity. Involved in forebrain regionalization. Acts upstream of or within several processes, including canonical Wnt signaling pathway; mesenchymal-epithelial cell signaling; and regulation of morphogenesis of a branching structure. Predic ted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; reproductive system; sensory organ; and urethra. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human WNT2B (Wnt family member 2B). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 104852121 | 104869025 | Mouse | 147 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8832082 | Wnt2b | Wnt family member 2B | INVOLVED IN canonical Wnt signaling pathway (ortholog); cellular response to starvation (ortholog); chondrocyte differentiation (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Diarrhea 9 (ortholog); endodermal sinus tumor (ortholog); Failure to Th rive (ortholog) | NW_004955435 | 15948262 | 15962958 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11757752 | WNT2B | Wnt family member 2B | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); signaling receptor binding (inferred); INVOLVED IN canonical Wnt signaling pathway (ortholog); cellular response to starvation (ortholog); lung induction (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Diarrhea 9 (ortholog); endodermal sinus tumor (ortholog); Failure to Thrive (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | 1 | 115119360 | 115177942 | Bonobo | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12255186 | WNT2B | Wnt family member 2B | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN canonical Wnt signaling pathway (ortholog); cellular response to starvation (ortholog); lung induction (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Diarrhea 9 (o rtholog); endodermal sinus tumor (ortholog); Failure to Thrive (ortholog); FOUND IN extracellular region (inferred) | 17 | 63034719 | 63054369 | Dog | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12609210 | Wnt2b | Wnt family member 2B | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); signaling receptor binding (inferred); INVOLVED IN canonical Wnt signaling pathway (ortholog); cellular response to starvation (ortholog); lung induction (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Diarrhea 9 (ortholog); endodermal sinus tumor (ortholog); Failure to Thrive (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | NW_004936690 | 1077538 | 1094005 | Squirrel | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14087032 | WNT2B | Wnt family member 2B | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN canonical Wnt signaling pathway (ortholog); cellular response to starvation (ortholog); lung induction (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Diarrhea 9 (o rtholog); endodermal sinus tumor (ortholog); Failure to Thrive (ortholog); FOUND IN extracellular region (inferred) | | | | Pig | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18718608 | WNT2B | Wnt family member 2B | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); signaling receptor binding (inferred); INVOLVED IN canonical Wnt signaling pathway (ortholog); cellular response to starvation (ortholog); lung induction (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Diarrhea 9 (ortholog); endodermal sinus tumor (ortholog); Failure to Thrive (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18905546 | Wnt2b | Wnt family member 2B | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); signaling receptor binding (inferred); INVOLVED IN canonical Wnt signaling pathway (ortholog); cellular response to starvation (ortholog); chondrocyte differentiation (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Diarrhea 9 (ortholog); endodermal sinus tumor (ortholog); Failure to Thrive (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Naked Mole-Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244760 | wnt2b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625910525 | Wnt2b | Wnt family member 2B | INVOLVED IN canonical Wnt signaling pathway (ortholog); cellular response to starvation (ortholog); chondrocyte differentiation (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Diarrhea 9 (ortholog); endodermal sinus tumor (ortholog); Failure to Th rive (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233122 | wnt2b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 733867 | WNT4 | Wnt family member 4 | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008] | 1 | 22117313 | 22143097 | Human | 441 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 16566873 | AL354760.1 | novel transcript, antisense to WNT2B | | | | | Human | | name | gene, lncrna |
| 1342887 | ST7L | suppression of tumorigenicity 7 like | This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancer s. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011] | 1 | 112517803 | 112619684 | Human | 66 | description | gene, protein-coding, REVIEWED [RefSeq] |