| 3930 | Uts2 | urotensin 2 | ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN blood vessel diameter maintenance; negative regulation of blood pressure; negative regulation of glomerular filtration; ASSOCIATED WITH asthma; cardiomyopathy; Diabetic Nephropathies; FOUND IN extracellular space; INTERACTS WIT H 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil; ammonium chloride | 5 | 166725471 | 166739063 | Rat | 100 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 737599 | UTS2 | urotensin 2 | This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] | 1 | 7847612 | 7913249 | Human | 103 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737600 | Uts2 | urotensin 2 | This gene encodes a member of the urotensin family of peptide hormones. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone before secretion into the plasma. Mice lacking the encoded protein have a significantly decreased low density lipoprotein choles terol profile and hepatic steatosis that is consistent with decreased hepatocyte de novo cholesterol synthesis and apolipoprotein B secretion. [provided by RefSeq, Sep 2016] | 4 | 151081554 | 151086267 | Mouse | 141 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8823134 | Uts2 | urotensin 2 | INVOLVED IN blood vessel diameter maintenance (ortholog); negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); ASSOCIATED WITH asthma (ortholog); Bradycardia (ortholog); cardiomyopathy (ortholog); FOUND IN extracellular space (ortholog) | NW_004955486 | 5052045 | 5056610 | Chinchilla | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11869273 | UTS2 | urotensin 2 | ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN blood vessel diameter maintenance (ortholog); negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); ASSOCIATED WITH asthma (ortholog); Bradycardia (ortholog); cardiomyopathy (ortholog); FOUND IN extracellular space (ortholog) | 1 | 6609104 | 6616966 | Bonobo | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12398904 | UTS2 | urotensin 2 | ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN blood vessel diameter maintenance (ortholog); negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); ASSOCIATED WITH asthma (ortholog); Bradycardia (ortholog); cardiomyopathy (ortholog); FOUND IN extracellular space (ortholog) | 5 | 61503268 | 61508146 | Dog | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12570850 | Uts2 | urotensin 2 | ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN blood vessel diameter maintenance (ortholog); negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); ASSOCIATED WITH asthma (ortholog); Bradycardia (ortholog); cardiomyopathy (ortholog); FOUND IN extracellular space (ortholog) | NW_004936623 | 2339259 | 2345717 | Squirrel | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13875868 | UTS2 | urotensin 2 | ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN blood vessel diameter maintenance (ortholog); negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); ASSOCIATED WITH asthma (ortholog); Bradycardia (ortholog); cardiomyopathy (ortholog); FOUND IN extracellular space (ortholog) | | | | Pig | 59 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18469752 | UTS2 | urotensin 2 | INVOLVED IN blood vessel diameter maintenance (ortholog); negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); ASSOCIATED WITH asthma (ortholog); Bradycardia (ortholog); cardiomyopathy (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285737068 | uts2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626098117 | Uts2 | urotensin 2 | INVOLVED IN blood vessel diameter maintenance (ortholog); negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); ASSOCIATED WITH asthma (ortholog); Bradycardia (ortholog); cardiomyopathy (ortholog); FOUND IN extracellular space (ortholog) | | | | Black Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285322021 | uts2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 286158023 | uts2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1551954 | Uts2b | urotensin 2B | Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in regulation of blood pressure. Predicted to be located in extracellular region. Is expressed in brain; male reproductive gland or organ; and metanephros. Orthologous to human UTS2 S2B (urotensin 2B). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 27172072 | 27188989 | Mouse | 38 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 727977 | Uts2b | urotensin 2B | ENCODES a protein that exhibits G protein-coupled receptor binding; INVOLVED IN regulation of blood pressure; FOUND IN extracellular region (inferred); INTERACTS WITH bisphenol A; furan; gentamycin | 11 | 86929210 | 86944255 | Rat | 36 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1603529 | UTS2B | urotensin 2B | Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in regulation of blood pressure. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 191267168 | 191346182 | Human | 39 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8948449 | Uts2b | urotensin 2B | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); INVOLVED IN regulation of blood pressure (ortholog) | NW_004955420 | 16947003 | 17016229 | Chinchilla | 2 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11717758 | UTS2B | urotensin 2B | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); INVOLVED IN regulation of blood pressure (ortholog) | 3 | 188559245 | 188622518 | Bonobo | 4 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12410685 | UTS2B | urotensin 2B | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); INVOLVED IN regulation of blood pressure (ortholog); FOUND IN extracellular region (inferred) | 34 | 23110145 | 23145025 | Dog | 11 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12526193 | Uts2b | urotensin 2B | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); INVOLVED IN regulation of blood pressure (ortholog) | NW_004936900 | 446668 | 451841 | Squirrel | 2 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14232546 | UTS2B | urotensin 2B | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); INVOLVED IN regulation of blood pressure (ortholog); FOUND IN extracellular region (inferred) | | | | Pig | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18353407 | UTS2B | urotensin 2B | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); INVOLVED IN regulation of blood pressure (ortholog) | | | | Green Monkey | 2 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932771 | Uts2b | urotensin 2B | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); INVOLVED IN regulation of blood pressure (ortholog) | | | | Naked Mole-Rat | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245177 | uts2b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626041462 | Uts2b | urotensin 2B | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); INVOLVED IN regulation of blood pressure (ortholog) | | | | Black Rat | 2 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 621884 | Uts2r | urotensin 2 receptor | ENCODES a protein that exhibits urotensin II receptor activity; INVOLVED IN negative regulation of blood pressure; negative regulation of glomerular filtration; negative regulation of urine volume; ASSOCIATED WITH acute kidney failure; cardiomyopathy; Diabetic Nephropathies; FOUND IN early endosome; recycling endosome; INTERACTS WITH ammonium chloride; C60 fullerene; copper atom | 10 | 106936398 | 106937558 | Rat | 69 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1332177 | Uts2r | urotensin 2 receptor | Predicted to enable urotensin II receptor activity. Predicted to be involved in several processes, including neuropeptide signaling pathway; regulation of blood pressure; and regulation of circadian sleep/wake cycle. Predicted to be located in early endosome and recycling endosome. Predicted to be a ctive in plasma membrane. Orthologous to human UTS2R (urotensin 2 receptor). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 121051097 | 121052799 | Mouse | 84 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1342744 | UTS2R | urotensin 2 receptor | Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 82371765 | 82377458 | Human | 75 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8868824 | Uts2r | urotensin 2 receptor | ENCODES a protein that exhibits urotensin II receptor activity (ortholog); INVOLVED IN negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); negative regulation of urine volume (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); cardiomyo pathy (ortholog); Diabetic Nephropathies (ortholog); FOUND IN early endosome (ortholog); recycling endosome (ortholog) | NW_004955506 | 756859 | 761891 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12015510 | UTS2R | urotensin 2 receptor | ENCODES a protein that exhibits urotensin II receptor activity (ortholog); INVOLVED IN negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); negative regulation of urine volume (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); cardiomyo pathy (ortholog); Diabetic Nephropathies (ortholog); FOUND IN early endosome (ortholog); recycling endosome (ortholog) | 17 | 76783432 | 76788639 | Bonobo | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12292700 | UTS2R | urotensin 2 receptor | ENCODES a protein that exhibits urotensin II receptor activity (ortholog); INVOLVED IN negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); negative regulation of urine volume (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); cardiomyo pathy (ortholog); Diabetic Nephropathies (ortholog); FOUND IN early endosome (ortholog); recycling endosome (ortholog) | | | | Dog | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12458556 | Uts2r | urotensin 2 receptor | ENCODES a protein that exhibits urotensin II receptor activity (ortholog); INVOLVED IN negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); negative regulation of urine volume (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); cardiomyo pathy (ortholog); Diabetic Nephropathies (ortholog); FOUND IN early endosome (ortholog); recycling endosome (ortholog) | NW_004936923 | 24952 | 31083 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14079654 | UTS2R | urotensin 2 receptor | ENCODES a protein that exhibits urotensin II receptor activity (ortholog); INVOLVED IN negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); negative regulation of urine volume (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); cardiomyo pathy (ortholog); Diabetic Nephropathies (ortholog); FOUND IN early endosome (ortholog); recycling endosome (ortholog) | | | | Pig | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18765670 | UTS2R | urotensin 2 receptor | ENCODES a protein that exhibits urotensin II receptor activity (ortholog); INVOLVED IN negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); negative regulation of urine volume (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); cardiomyo pathy (ortholog); Diabetic Nephropathies (ortholog); FOUND IN early endosome (ortholog); recycling endosome (ortholog) | | | | Green Monkey | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241823 | uts2r | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626055093 | Uts2r | urotensin 2 receptor | ENCODES a protein that exhibits urotensin II receptor activity (ortholog); INVOLVED IN negative regulation of blood pressure (ortholog); negative regulation of glomerular filtration (ortholog); negative regulation of urine volume (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); cardiomyo pathy (ortholog); Diabetic Nephropathies (ortholog); FOUND IN early endosome (ortholog); recycling endosome (ortholog) | | | | Black Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288056929 | uts2rl | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155243451 | uts2b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155238377 | uts2b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155230874 | uts2r.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155255291 | uts2r.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 288083369 | uts2rl2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 284241986 | uts2rl3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 329329261 | uts2rl3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284701039 | uts2rl3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596933935 | uts2rl3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596935157 | uts2rl3.S | | | | | | African Clawed Frog | | symbol | gene, null |