Uts2 (urotensin 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Uts2 (urotensin 2) Mus musculus
Analyze
Symbol: Uts2
Name: urotensin 2
RGD ID: 737600
MGI Page MGI
Description: Predicted to enable hormone activity. Predicted to be involved in several processes, including regulation of blood pressure; regulation of circadian sleep/wake cycle; and regulation of heart rate. Predicted to be active in extracellular space. Is expressed in several structures, including Harderian gland; alimentary system; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in gestational diabetes; hypertension; and type 2 diabetes mellitus. Orthologous to human UTS2 (urotensin 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: MGC130253; MGC130254; pre; prepro-UII; U-II; Ucn; Ucn2; UII; urocortin 2; urotensin II; urotensin-2; urotensin-II
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394151,081,554 - 151,086,267 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4151,081,554 - 151,086,267 (+)EnsemblGRCm39 Ensembl
GRCm384150,997,097 - 151,001,810 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,997,097 - 151,001,810 (+)EnsemblGRCm38mm10GRCm38
MGSCv374150,371,206 - 150,375,919 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364149,840,897 - 149,845,610 (+)NCBIMGSCv36mm8
Celera4153,272,921 - 153,277,635 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map481.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Increased plasma levels of Urotensin-II in preeclampsia-eclampsia: a new mediator in pathogenesis? Balat O, etal., Eur J Obstet Gynecol Reprod Biol. 2005 May 1;120(1):33-8.
2. Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta. Bousette N, etal., Atherosclerosis. 2004 Sep;176(1):117-23.
3. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases Cheng DY, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Jun;29(6):381-4.
4. Plasma concentration of urotensin II is raised in hypertension. Cheung BM, etal., J Hypertens. 2004 Jul;22(7):1341-4.
5. Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors. Coulouarn Y, etal., FEBS Lett 1999 Aug 20;457(1):28-32.
6. Elevated expression of urotensin II and its receptor in diabetic cardiomyopathy. Dai HY, etal., J Diabetes Complications. 2008 Mar-Apr;22(2):137-43.
7. Circulating urotensin II levels in moderate to severe congestive heart failure: its relations with myocardial function and well established neurohormonal markers. Gruson D, etal., Peptides. 2006 Jun;27(6):1527-31. Epub 2005 Dec 20.
8. Urotensin-II-mediated cardiomyocyte hypertrophy: effect of receptor antagonism and role of inflammatory mediators. Johns DG, etal., Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct;370(4):238-50. Epub 2004 Sep 30.
9. Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy. Langham RG, etal., Am J Kidney Dis. 2004 Nov;44(5):826-31.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury. Prosser HC, etal., Peptides. 2008 May;29(5):770-7. Epub 2007 Aug 21.
14. The upregulation of endothelial nitric oxide synthase and urotensin-II is associated with pulmonary hypertension and vascular diseases in rats produced by aortocaval shunting. Qi J, etal., Heart Vessels. 2004 Mar;19(2):81-8.
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure. Russell FD, etal., Am J Physiol Heart Circ Physiol. 2003 Oct;285(4):H1576-81. Epub 2003 Jun 5.
18. Increased plasma urotensin-II levels are associated with diabetic retinopathy and carotid atherosclerosis in Type 2 diabetes. Suguro T, etal., Clin Sci (Lond). 2008 Dec;115(11):327-34.
19. Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese. Suzuki S, etal., Peptides. 2004 Oct;25(10):1803-8.
20. [Role of urotensin II gene in the genetic susceptibility to gestational diabetes mellitus in northern Chinese women]. Tan YJ, etal., Zhonghua Fu Chan Ke Za Zhi. 2006 Nov;41(11):732-5.
21. Diabetes-induced upregulation of urotensin II and its receptor plays an important role in TGF-beta1-mediated renal fibrosis and dysfunction. Tian L, etal., Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1234-42. Epub 2008 Sep 16.
22. Elevated plasma levels of immunoreactive urotensin II and its increased urinary excretion in patients with Type 2 diabetes mellitus: association with progress of diabetic nephropathy. Totsune K, etal., Peptides. 2004 Oct;25(10):1809-14.
23. Elevated expression of urotensin II and its receptor in skeletal muscle of diabetic mouse. Wang HX, etal., Regul Pept. 2009 Apr 10;154(1-3):85-90. doi: 10.1016/j.regpep.2009.01.004. Epub 2009 Jan 27.
24. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics Wu XJ, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Dec;24(6):656-9.
25. Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol. Zhang YG, etal., Acta Pharmacol Sin. 2007 Jan;28(1):36-43.
26. Urotensin II is an inverse predictor of incident cardiovascular events in end-stage renal disease. Zoccali C, etal., Kidney Int. 2006 Apr;69(7):1253-8.
Additional References at PubMed
PMID:12477932   PMID:16160878   PMID:16361078   PMID:16602821   PMID:18710417   PMID:18806619   PMID:20562862   PMID:21376094   PMID:21605557   PMID:21677750   PMID:21873635   PMID:22723440  
PMID:22886350   PMID:23344731   PMID:23755157   PMID:24194600   PMID:25805930   PMID:27448985   PMID:29133126   PMID:31238319   PMID:36892588   PMID:38355793  


Genomics

Comparative Map Data
Uts2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394151,081,554 - 151,086,267 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4151,081,554 - 151,086,267 (+)EnsemblGRCm39 Ensembl
GRCm384150,997,097 - 151,001,810 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,997,097 - 151,001,810 (+)EnsemblGRCm38mm10GRCm38
MGSCv374150,371,206 - 150,375,919 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364149,840,897 - 149,845,610 (+)NCBIMGSCv36mm8
Celera4153,272,921 - 153,277,635 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map481.53NCBI
UTS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3817,847,612 - 7,913,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl17,843,083 - 7,853,512 (-)EnsemblGRCh38hg38GRCh38
GRCh3717,907,672 - 7,913,551 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3617,830,262 - 7,836,159 (-)NCBINCBI36Build 36hg18NCBI36
Build 3417,841,940 - 7,847,838NCBI
Celera17,015,352 - 7,021,232 (-)NCBICelera
Cytogenetic Map1p36.23NCBI
HuRef17,055,968 - 7,061,853 (-)NCBIHuRef
CHM1_117,895,413 - 7,901,298 (-)NCBICHM1_1
T2T-CHM13v2.017,378,659 - 7,444,444 (-)NCBIT2T-CHM13v2.0
Uts2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85166,725,471 - 166,739,063 (+)NCBIGRCr8
mRatBN7.25161,450,846 - 161,456,235 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,450,846 - 161,456,237 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5164,167,730 - 164,173,039 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,984,293 - 165,989,452 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,946,373 - 165,951,683 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05168,078,748 - 168,084,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5168,078,748 - 168,084,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05171,655,843 - 171,661,228 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45168,143,315 - 168,148,700 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15168,153,502 - 168,158,888 (+)NCBI
Celera5159,703,053 - 159,708,438 (+)NCBICelera
Cytogenetic Map5q36NCBI
Uts2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554865,052,045 - 5,056,610 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554865,052,045 - 5,056,610 (+)NCBIChiLan1.0ChiLan1.0
UTS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21220,372,481 - 220,378,795 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11219,012,271 - 219,019,892 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016,609,104 - 6,616,966 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.117,853,824 - 7,864,688 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl17,854,687 - 7,864,688 (-)Ensemblpanpan1.1panPan2
UTS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1561,503,268 - 61,508,146 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha561,512,208 - 61,524,420 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0561,720,176 - 61,732,192 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl561,720,240 - 61,722,254 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1561,719,384 - 61,731,402 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0561,583,986 - 61,596,155 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0561,987,535 - 61,999,550 (-)NCBIUU_Cfam_GSD_1.0
Uts2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505831,855,288 - 31,860,643 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366232,340,778 - 2,345,700 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366232,339,259 - 2,345,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UTS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl668,552,887 - 68,559,674 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1668,552,889 - 68,560,827 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
UTS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120123,903,137 - 123,910,180 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605427,938,370 - 27,944,781 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Uts2
310 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:92
Interacting mature miRNAs:96
Transcripts:ENSMUST00000030803
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000030803   ⟹   ENSMUSP00000030803
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4151,081,554 - 151,086,267 (+)Ensembl
GRCm38.p6 Ensembl4150,997,097 - 151,001,810 (+)Ensembl
RefSeq Acc Id: NM_011910   ⟹   NP_036040
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394151,081,554 - 151,086,267 (+)NCBI
GRCm384150,997,097 - 151,001,810 (+)ENTREZGENE
MGSCv374150,371,206 - 150,375,919 (+)RGD
Celera4153,272,921 - 153,277,635 (+)RGD
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_036040 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD55767 (Get FASTA)   NCBI Sequence Viewer  
  AAI07300 (Get FASTA)   NCBI Sequence Viewer  
  AAI07301 (Get FASTA)   NCBI Sequence Viewer  
  AAL55430 (Get FASTA)   NCBI Sequence Viewer  
  EDL14901 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000030803
  ENSMUSP00000030803.2
GenBank Protein Q9QZQ3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036040   ⟸   NM_011910
- Peptide Label: preproprotein
- UniProtKB: Q9QZQ3 (UniProtKB/Swiss-Prot),   Q541G7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000030803   ⟸   ENSMUST00000030803

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZQ3-F1-model_v2 AlphaFold Q9QZQ3 1-123 view protein structure

Promoters
RGD ID:6885626
Promoter ID:EPDNEW_M6264
Type:multiple initiation site
Name:Uts2_1
Description:Mus musculus urotensin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384150,997,085 - 150,997,145EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346329 AgrOrtholog
Ensembl Genes ENSMUSG00000028963 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030803 ENTREZGENE
  ENSMUST00000030803.2 UniProtKB/Swiss-Prot
InterPro Urotensin_II UniProtKB/Swiss-Prot
KEGG Report mmu:24111 UniProtKB/Swiss-Prot
MGD MGI:1346329 ENTREZGENE
NCBI Gene 24111 ENTREZGENE
PANTHER UROTENSIN 2 UniProtKB/Swiss-Prot
  UROTENSIN-2 UniProtKB/Swiss-Prot
Pfam Urotensin_II UniProtKB/Swiss-Prot
PhenoGen Uts2 PhenoGen
PROSITE UROTENSIN_II UniProtKB/Swiss-Prot
UniProt Q541G7 ENTREZGENE, UniProtKB/TrEMBL
  Q9QZQ3 ENTREZGENE, UniProtKB/Swiss-Prot