| 620765 | Ucn2 | urocortin 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 2 binding; corticotropin-releasing hormone receptor binding (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN cellular response to glucocorticoid stimulus; cellular response to hypoxia; negative regulation of follicle-stimulating hormone secretion; PARTICIPATES IN corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH colitis; Anorexia (ortholog); atherosclerosis (ortholog); FOUND IN extracellular space; INTERACTS WITH ammonium chloride; atrazine; bisphenol A | 8 | 118516111 | 118517660 | Rat | 60 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1348669 | UCN2 | urocortin 2 | This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008] | 3 | 48561718 | 48563781 | Human | 61 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1614218 | Ucn2 | urocortin 2 | This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded p rotein exhibit increased insulin sensitivity and were protected against fat-induced insulin resistance. In addition, female mice lacking the encoded protein exhibit a significant increase in the basal daily rhythms of adrenocorticotropic hormone and corticosterone, and a significant decrease in fluid intake and depressive-like behavior. [provided by RefSeq, Sep 2016] | 9 | 108815231 | 108816232 | Mouse | 74 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8733480 | Ucn2 | urocortin 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 2 binding (ortholog); corticotropin-releasing hormone receptor binding (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to glucocorticoid stimulus (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH Anorexia (ortholog); atherosclerosis (ortholog); colitis (ortholog); FOUND IN extracellular space (ortholog) | NW_004955532 | 648845 | 650020 | Chinchilla | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11794784 | UCN2 | urocortin 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 2 binding (ortholog); corticotropin-releasing hormone receptor binding (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to glucocorticoid stimulus (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH Anorexia (ortholog); atherosclerosis (ortholog); colitis (ortholog); FOUND IN extracellular space (ortholog) | 3 | 48484628 | 48485179 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12260462 | UCN2 | urocortin 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 2 binding (ortholog); corticotropin-releasing hormone receptor binding (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to glucocorticoid stimulus (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH Anorexia (ortholog); atherosclerosis (ortholog); colitis (ortholog); FOUND IN extracellular space (ortholog) | 20 | 40551060 | 40552920 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12692043 | Ucn2 | urocortin 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 2 binding (ortholog); corticotropin-releasing hormone receptor binding (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to glucocorticoid stimulus (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH Anorexia (ortholog); atherosclerosis (ortholog); colitis (ortholog); FOUND IN extracellular space (ortholog) | NW_004936529 | 347411 | 348040 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625956017 | Ucn2 | urocortin 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 2 binding (ortholog); corticotropin-releasing hormone receptor binding (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to glucocorticoid stimulus (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH Anorexia (ortholog); atherosclerosis (ortholog); colitis (ortholog); FOUND IN extracellular space (ortholog) | | | | Black Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18927081 | Ucn2 | urocortin 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 2 binding (ortholog); G protein-coupled receptor binding (ortholog); hormone binding (ortholog); INVOLVED IN cellular response to glucocorticoid stimulus (ortholog); cellular response to hypoxia (ortholog); negative regulation of follicle-stimulating hormone secretion (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH Anorexia (ortholog); atherosclerosis (ortholog); colitis (ortholog); FOUND IN extracellular space (ortholog) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20867464 | UCN2 | urocortin 2 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 14143122 | UCN2 | urocortin 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 2 binding (ortholog); INVOLVED IN cellular response to glucocorticoid stimulus (ortholog); cellular response to hypoxia (ortholog); negative regulation of follicle-stimulating hormone secretion (ortholog); PARTICIPATES IN corti cotropin-releasing hormone signaling pathway; ASSOCIATED WITH Anorexia (ortholog); atherosclerosis (ortholog); colitis (ortholog); FOUND IN extracellular space (ortholog) | | | | Pig | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18545830 | UCN2 | urocortin 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 2 binding (ortholog); INVOLVED IN cellular response to glucocorticoid stimulus (ortholog); cellular response to hypoxia (ortholog); negative regulation of follicle-stimulating hormone secretion (ortholog); PARTICIPATES IN corti cotropin-releasing hormone signaling pathway; ASSOCIATED WITH Anorexia (ortholog); atherosclerosis (ortholog); colitis (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 3930 | Uts2 | urotensin 2 | ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN blood vessel diameter maintenance; negative regulation of blood pressure; negative regulation of glomerular filtration; ASSOCIATED WITH asthma; cardiomyopathy; Diabetic Nephropathies; FOUND IN extracellular space; INTERACTS WIT H 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil; ammonium chloride | 5 | 166725471 | 166739063 | Rat | 100 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737599 | UTS2 | urotensin 2 | This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] | 1 | 7847612 | 7913249 | Human | 103 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 737600 | Uts2 | urotensin 2 | This gene encodes a member of the urotensin family of peptide hormones. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone before secretion into the plasma. Mice lacking the encoded protein have a significantly decreased low density lipoprotein choles terol profile and hepatic steatosis that is consistent with decreased hepatocyte de novo cholesterol synthesis and apolipoprotein B secretion. [provided by RefSeq, Sep 2016] | 4 | 151081554 | 151086267 | Mouse | 141 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |