| 3926 | Ube2i | ubiquitin-conjugating enzyme E2I | ENCODES a protein that exhibits bHLH transcription factor binding; ionotropic glutamate receptor binding; SUMO transferase activity; INVOLVED IN obsolete positive regulation of DNA-binding transcription factor activity; positive regulation of intracellular steroid hormone receptor signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; PARTICIPATES IN altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; sumoylation pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); dilated cardiomyopathy (ortholog); FOUND IN dendrite; fibrillar center; nuclear body; INTERACTS WITH (+)-pilocarpine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil | 10 | 14782245 | 14802911 | Rat | 204 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 11469 | Ube2i | ubiquitin-conjugating enzyme E2I | Enables HLH domain binding activity and SUMO conjugating enzyme activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nuclear export; and protein sumoylation. Acts upstream of or within positive regulation of canonical NF-kappaB signal transduc tion. Located in nuclear body. Part of SUMO ligase complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in several structures, including early embryo; forebrain; forelimb bud; limb; and oocyte. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 25479484 | 25494965 | Mouse | 251 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 734464 | UBE2I | ubiquitin conjugating enzyme E2 I | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] | 16 | 1309152 | 1327017 | Human | 272 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8778258 | Ube2i | ubiquitin conjugating enzyme E2 I | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); enzyme binding (ortholog); HLH domain binding (ortholog); INVOLVED IN import into nucleus (ortholog); modulation of chemical synaptic transmission (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN aldosterone signaling pathway; altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); dilated cardiomyopathy (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); fibrillar center (ortholog) | NW_004955442 | 15902026 | 15913033 | Chinchilla | 133 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12025556 | UBE2I | ubiquitin conjugating enzyme E2 I | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); ionotropic glutamate receptor binding (ortholog); SUMO transferase activity (ortholog); INVOLVED IN nuclear export (ortholog); obsolete positive regulation of DNA-binding transcription factor activity (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); PARTICIPATES IN aldosterone signaling pathway; altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); dilated cardiomyopathy (ortholog); FOUND IN dendrite (ortholog); fibrillar center (ortholog); nuclear body (ortholog) | | | | Bonobo | 136 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12325594 | UBE2I | ubiquitin conjugating enzyme E2 I | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); enzyme binding (ortholog); HLH domain binding (ortholog); INVOLVED IN import into nucleus (ortholog); modulation of chemical synaptic transmission (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN aldosterone signaling pathway; altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); dilated cardiomyopathy (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); fibrillar center (ortholog) | 6 | 39440123 | 39453688 | Dog | 136 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12601608 | Ube2i | ubiquitin conjugating enzyme E2 I | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); enzyme binding (ortholog); HLH domain binding (ortholog); INVOLVED IN import into nucleus (ortholog); modulation of chemical synaptic transmission (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN aldosterone signaling pathway; altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); dilated cardiomyopathy (ortholog); FOUND IN dendrite (ortholog); fibrillar center (ortholog); glutamatergic synapse (ortholog) | NW_004936694 | 2561701 | 2571284 | Squirrel | 139 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 13867512 | UBE2I | ubiquitin conjugating enzyme E2 I | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); enzyme binding (ortholog); HLH domain binding (ortholog); INVOLVED IN import into nucleus (ortholog); modulation of chemical synaptic transmission (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN aldosterone signaling pathway; altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); dilated cardiomyopathy (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); fibrillar center (ortholog) | | | | Pig | 72 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18526653 | UBE2I | ubiquitin conjugating enzyme E2 I | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); ionotropic glutamate receptor binding (ortholog); SUMO transferase activity (ortholog); INVOLVED IN nuclear export (ortholog); obsolete positive regulation of DNA-binding transcription factor activity (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); PARTICIPATES IN aldosterone signaling pathway; altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); dilated cardiomyopathy (ortholog); FOUND IN dendrite (ortholog); fibrillar center (ortholog); nuclear body (ortholog) | | | | Green Monkey | 136 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18927338 | Ube2i | ubiquitin conjugating enzyme E2 I | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); enzyme binding (ortholog); HLH domain binding (ortholog); INVOLVED IN import into nucleus (ortholog); modulation of chemical synaptic transmission (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN aldosterone signaling pathway; altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); dilated cardiomyopathy (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); fibrillar center (ortholog) | | | | Naked Mole-Rat | 137 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866793 | UBE2I | ubiquitin conjugating enzyme E2 I | | | | | Green Monkey | | symbol | gene, protein-coding |
| 155234920 | ube2i | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626057448 | Ube2i | ubiquitin conjugating enzyme E2 I | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); enzyme binding (ortholog); HLH domain binding (ortholog); INVOLVED IN import into nucleus (ortholog); modulation of chemical synaptic transmission (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN aldosterone signaling pathway; altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); dilated cardiomyopathy (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); fibrillar center (ortholog) | | | | Black Rat | 133 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240611 | ube2i.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259846 | ube2i.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16562899 | UBE2I-AS1 | UBE2I antisense RNA 1 | | | | | Human | | symbol , COSMIC , name , Human Proteome Map | gene, lncrna |
| 151671720 | UBE2I-AS1 | UBE2I antisense RNA 1 | | 16 | 1293507 | 1299605 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1566292 | Ube2i-ps1 | ubiquitin-conjugating enzyme E2I, pseudogene 1 | INTERACTS WITH indole-3-methanol | 14 | 54720014 | 54720937 | Rat | 1 | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 15039207 | Ube2i-ps1 | ubiquitin-conjugating enzyme E2I, pseudogene 1 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 2320136 | Ube2i-ps2 | ubiquitin-conjugating enzyme E2I, pseudogene 2 | | 11 | 57099095 | 57125744 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 15039155 | Ube2i-ps2 | ubiquitin-conjugating enzyme E2I, pseudogene 2 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 1587060 | Ube2i-ps3 | ubiquitin-conjugating enzyme E2I, pseudogene 3 | | 6 | 74539449 | 74540831 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 15037265 | Ube2i-ps3 | ubiquitin-conjugating enzyme E2I, pseudogene 3 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 7518044 | Ube2i-ps4 | ubiquitin-conjugating enzyme E2I, pseudogene 4 | | 10 | 70199368 | 70200062 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 40982266 | Ube2i-ps5 | ubiquitin-conjugating enzyme E2I, pseudogene 5 | | 9 | 43478350 | 43480327 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41185982 | Ube2i-ps6 | ubiquitin-conjugating enzyme E2I, pseudogene 6 | | 4 | 12055341 | 12056095 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16567324 | AC120498.9 | novel transcript, antisense to UBE2I | | | | | Human | | name | gene, lncrna |
| 16563308 | AL031714.1 | novel transcript, antisense to UBE2I | | | | | Human | | name | gene, lncrna |
| 16553342 | AC016907.1 | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) (UBE2I) pseudogene | | | | | Human | | name | gene, processed_pseudogene |