| 620053 | Trpm7 | transient receptor potential cation channel, subfamily M, member 7 | ENCODES a protein that exhibits calcium channel activity; monoatomic cation channel activity; protein kinase activity; INVOLVED IN calcium ion transport; intracellular magnesium ion homeostasis; memory; ASSOCIATED WITH Reperfusion Injury; adenoma (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN neuronal cell body; synaptic vesicle membrane; varicosity; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 4,4'-diaminodiphenylmethane | 3 | 134499617 | 134588113 | Rat | 221 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1353386 | TRPM7 | transient receptor potential cation channel subfamily M member 7 | This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular c alcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017] | 15 | 50557158 | 50686797 | Human | 233 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557461 | Trpm7 | transient receptor potential cation channel, subfamily M, member 7 | Enables cytoskeletal protein binding activity; metal ion transmembrane transporter activity; and protein kinase activity. Involved in intracellular magnesium ion homeostasis; metal ion transport; and protein homotetramerization. Acts upstream of or within several processes, including actomyosin stru cture organization; calcium-dependent cell-matrix adhesion; and protein autophosphorylation. Located in several cellular components, including cytoplasmic vesicle; nucleus; and ruffle. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and skin. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 126633478 | 126718181 | Mouse | 290 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9043529 | Trpm7 | transient receptor potential cation channel subfamily M member 7 | ENCODES a protein that exhibits actin binding (ortholog); calcium channel activity (ortholog); kinase activity (ortholog); INVOLVED IN actomyosin structure organization (ortholog); calcium ion transmembrane transport (ortholog); calcium ion transport (ortholog); ASSOCIATED WITH adenoma (ortholog); a myotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ortholog); FOUND IN cytoplasmic vesicle (ortholog); neuronal cell body (ortholog); nucleus (ortholog) | NW_004955409 | 3690722 | 3787139 | Chinchilla | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11869868 | TRPM7 | transient receptor potential cation channel subfamily M member 7 | ENCODES a protein that exhibits calcium channel activity (ortholog); monoatomic cation channel activity (ortholog); protein kinase activity (ortholog); INVOLVED IN actomyosin structure organization (ortholog); calcium ion transport (ortholog); calcium-dependent cell-matrix adhesion (ortholog); ASSOC IATED WITH adenoma (ortholog); amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ortholog); FOUND IN neuronal cell body (ortholog); synaptic vesicle membrane (ortholog); varicosity (ortholog) | 15 | 29513220 | 29639506 | Bonobo | 89 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12252903 | TRPM7 | transient receptor potential cation channel subfamily M member 7 | ENCODES a protein that exhibits calcium channel activity (ortholog); monoatomic cation channel activity (ortholog); protein kinase activity (ortholog); INVOLVED IN actomyosin structure organization (ortholog); calcium ion transport (ortholog); calcium-dependent cell-matrix adhesion (ortholog); ASSOC IATED WITH adenoma (ortholog); amyotrophic lateral sclerosis (ortholog); Colonic Polyps (ortholog); FOUND IN neuronal cell body (ortholog); synaptic vesicle membrane (ortholog); varicosity (ortholog) | 30 | 16465546 | 16579874 | Dog | 86 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12734017 | Trpm7 | transient receptor potential cation channel subfamily M member 7 | ENCODES a protein that exhibits calcium channel activity (ortholog); monoatomic cation channel activity (ortholog); protein kinase activity (ortholog); INVOLVED IN actomyosin structure organization (ortholog); calcium ion transport (ortholog); calcium-dependent cell-matrix adhesion (ortholog); ASSOC IATED WITH adenoma (ortholog); amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ortholog); FOUND IN neuronal cell body (ortholog); synaptic vesicle membrane (ortholog); varicosity (ortholog) | NW_004936471 | 12564617 | 12666229 | Squirrel | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235749 | trpm7 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13995424 | TRPM7 | transient receptor potential cation channel subfamily M member 7 | ENCODES a protein that exhibits calcium channel activity (ortholog); monoatomic cation channel activity (ortholog); protein kinase activity (ortholog); INVOLVED IN actomyosin structure organization (ortholog); calcium ion transport (ortholog); calcium-dependent cell-matrix adhesion (ortholog); ASSOC IATED WITH adenoma (ortholog); amyotrophic lateral sclerosis (ortholog); Colonic Polyps (ortholog); FOUND IN neuronal cell body (ortholog); synaptic vesicle membrane (ortholog); varicosity (ortholog) | | | | Pig | 90 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626081834 | Trpm7 | transient receptor potential cation channel subfamily M member 7 | ENCODES a protein that exhibits actin binding (ortholog); calcium channel activity (ortholog); kinase activity (ortholog); INVOLVED IN actomyosin structure organization (ortholog); calcium ion transmembrane transport (ortholog); calcium ion transport (ortholog); ASSOCIATED WITH adenoma (ortholog); a myotrophic lateral sclerosis (ortholog); Colonic Polyps (ortholog); FOUND IN cytoplasmic vesicle (ortholog); neuronal cell body (ortholog); nucleus (ortholog) | | | | Black Rat | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18525752 | TRPM7 | transient receptor potential cation channel subfamily M member 7 | ENCODES a protein that exhibits calcium channel activity (ortholog); monoatomic cation channel activity (ortholog); protein kinase activity (ortholog); INVOLVED IN actomyosin structure organization (ortholog); calcium ion transport (ortholog); calcium-dependent cell-matrix adhesion (ortholog); ASSOC IATED WITH adenoma (ortholog); amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ortholog); FOUND IN neuronal cell body (ortholog); synaptic vesicle membrane (ortholog); varicosity (ortholog) | | | | Green Monkey | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930814 | Trpm7 | transient receptor potential cation channel subfamily M member 7 | ENCODES a protein that exhibits calcium channel activity (ortholog); monoatomic cation channel activity (ortholog); protein kinase activity (ortholog); INVOLVED IN actomyosin structure organization (ortholog); calcium ion transport (ortholog); calcium-dependent cell-matrix adhesion (ortholog); ASSOC IATED WITH adenoma (ortholog); amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ortholog); FOUND IN neuronal cell body (ortholog); synaptic vesicle membrane (ortholog); varicosity (ortholog) | | | | Naked Mole-Rat | 92 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235748 | trpm7.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243949 | trpm7.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 284311674 | XB5892783 [provisional:trpm7] | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 16562353 | AC084756.1 | novel transcript, antisense to TRPM7 | | | | | Human | | name | gene, lncrna |