| 1343933 | TRIM25 | tripartite motif containing 25 | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 ligase and is involved in mu ltiple cellular processes, including regulation of antiviral innate immunity. [provided by RefSeq, Sep 2021] | 17 | 56887909 | 56914049 | Human | 197 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1594396 | Trim25 | tripartite motif-containing 25 | ENCODES a protein that exhibits RIG-I binding (ortholog); transcription coactivator activity (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN response to estrogen; response to vitamin D; antiviral innate immune response (ortholog); PARTICIPATES IN influenza A pathway; Retinoic a cid-inducible gene (RIG) I-like receptor signaling pathway; ASSOCIATED WITH Joubert syndrome (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic stress granule (ortholog); cytosol (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 74310024 | 74328473 | Rat | 204 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1614192 | Trim25 | tripartite motif-containing 25 | Predicted to enable RIG-I binding activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in host-mediated suppression of symbiont invasion; regulation of protein localization; and suppression of viral release by host. Acts upstream of or within cellular respons e to leukemia inhibitory factor. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human TRIM25 (tripartite motif containing 25). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 88890194 | 88911119 | Mouse | 216 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8905887 | Trim25 | tripartite motif containing 25 | ENCODES a protein that exhibits RIG-I binding (ortholog); transcription coactivator activity (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); cellular response to leukemia inhibitory factor (ortholog); cytoplasmic pattern recognition receptor signaling pathway (ortholog); ASSOCIATED WITH Joubert syndrome (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic stress granule (ortholog); cytosol (ortholog) | NW_004955451 | 5918287 | 5934252 | Chinchilla | 41 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11891550 | TRIM25 | tripartite motif containing 25 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); response to estrogen (ortholog); response to vitamin D (ortholog); ASSOCIATED WITH Joubert syndrome (ortholog); FOUND IN cytoplasm (inferred); cy toplasmic stress granule (inferred); cytosol (inferred) | 17 | 50965592 | 50991630 | Bonobo | 56 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12361388 | TRIM25 | tripartite motif containing 25 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); response to estrogen (ortholog); response to vitamin D (ortholog); ASSOCIATED WITH Joubert syndrome (ortholog); FOUND IN cytoplasm (inferred); cy toplasmic stress granule (inferred); cytosol (inferred) | 9 | 31703628 | 31725674 | Dog | 49 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12590971 | Trim25 | tripartite motif containing 25 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); response to estrogen (ortholog); response to vitamin D (ortholog); ASSOCIATED WITH Joubert syndrome (ortholog); FOUND IN cytoplasm (inferred); cy toplasmic stress granule (inferred); cytosol (inferred) | NW_004936490 | 5979320 | 5997632 | Squirrel | 49 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18927940 | Trim25 | tripartite motif containing 25 | ENCODES a protein that exhibits RIG-I binding (ortholog); transcription coactivator activity (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); cellular response to leukemia inhibitory factor (ortholog); cytoplasmic pattern recognition receptor signaling pathway (ortholog); ASSOCIATED WITH Joubert syndrome (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | | | | Naked Mole-Rat | 50 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626003260 | Trim25 | tripartite motif containing 25 | ENCODES a protein that exhibits RIG-I binding (ortholog); transcription coactivator activity (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); cellular response to leukemia inhibitory factor (ortholog); cytoplasmic pattern recognition receptor signaling pathway (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic stress granule (ortholog); cytosol (ortholog) | | | | Black Rat | 40 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 598152730 | trim25 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14038489 | TRIM25 | tripartite motif containing 25 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); response to estrogen (ortholog); response to vitamin D (ortholog); ASSOCIATED WITH Joubert syndrome (ortholog); FOUND IN cytoplasm (inferred); cy toplasmic stress granule (inferred); cytosol (inferred) | | | | Pig | 54 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18762710 | TRIM25 | tripartite motif containing 25 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); response to estrogen (ortholog); response to vitamin D (ortholog); ASSOCIATED WITH Joubert syndrome (ortholog); FOUND IN cytoplasm (inferred); cy toplasmic stress granule (inferred); cytosol (inferred) | | | | Green Monkey | 56 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1585067 | Trim25-ps1 | tripartite motif-containing 25, pseudogene 1 | | 1 | 111486077 | 111535886 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 286294015 | XB5765006 [provisional:trim25] | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 16563515 | AC015912.1 | novel transcript, antisense to TRIM25 | | | | | Human | | name | gene, lncrna |
| 18920346 | LOC101716688 | E3 ubiquitin/ISG15 ligase TRIM25-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 625895573 | LOC116893285 | E3 ubiquitin/ISG15 ligase TRIM25-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 625888403 | LOC116910227 | E3 ubiquitin/ISG15 ligase TRIM25-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 38602746 | IPAN | inhibitor of RIG-I/TRIM25 mediated viral protein degradation ncRNA | | 1 | 88462888 | 88469762 | Human | | name | gene, ncrna, MODEL [RefSeq] |
| 1311352 | Trim80 | tripartite motif protein 80 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN immune system process (inferred); innate immune response (inferred); FOUND IN cytoplasm (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3-chloropropan e-1,2-diol | 10 | 101181797 | 101190122 | Rat | 18 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 12174727 | TRIM80 | tripartite motif containing 80 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN immune system process (inferred); innate immune response (inferred); FOUND IN cytoplasm (inferred) | 9 | 5401186 | 5407129 | Dog | 6 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 284133782 | trim25l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 284132617 | trim25l.L | | | | | | African Clawed Frog | | symbol | gene, null |