| 3904 | Trhr | thyrotropin releasing hormone receptor | ENCODES a protein that exhibits identical protein binding; thyrotropin-releasing hormone receptor activity; INVOLVED IN positive regulation of cytosolic calcium ion concentration; positive regulation of protein-containing complex assembly; PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH hypertension; congenital hypothyroidism (ortholog); congenital nongoitrous hypothyroidism 7 (ortholog); FOUND IN cell surface; INTERACTS WITH (+)-pilocarpine; 2,2',4,4',5,5'-hexachlorobiphenyl; 3,3',5,5'-tetrabromobisphenol A | 7 | 77233175 | 77277988 | Rat | 80 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 11453 | Trhr | thyrotropin releasing hormone receptor | Predicted to enable identical protein binding activity and thyrotropin-releasing hormone receptor activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and positive regulation of prot ein-containing complex assembly. Predicted to be located in cell surface. Is expressed in several structures, including alimentary system; brain; heart; sensory organ; and skeleton. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 7 and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 44059314 | 44099308 | Mouse | 102 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 737056 | TRHR | thyrotropin releasing hormone receptor | This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone res istance. [provided by RefSeq, Sep 2011] | 8 | 109086585 | 109121565 | Human | 113 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8857165 | Trhr | thyrotropin releasing hormone receptor | ENCODES a protein that exhibits identical protein binding (ortholog); thyrotropin-releasing hormone receptor activity (ortholog); INVOLVED IN positive regulation of cytosolic calcium ion concentration (ortholog); positive regulation of protein-containing complex assembly (ortholog); ASSOCIATED WITH congenital hypothyroidism (ortholog); congenital nongoitrous hypothyroidism 7 (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog) | NW_004955417 | 16529293 | 16565359 | Chinchilla | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11829347 | TRHR | thyrotropin releasing hormone receptor | ENCODES a protein that exhibits identical protein binding (ortholog); thyrotropin-releasing hormone receptor activity (ortholog); INVOLVED IN positive regulation of cytosolic calcium ion concentration (ortholog); positive regulation of protein-containing complex assembly (ortholog); ASSOCIATED WITH congenital hypothyroidism (ortholog); congenital nongoitrous hypothyroidism 7 (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog) | 8 | 105739651 | 105780470 | Bonobo | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12358651 | TRHR | thyrotropin releasing hormone receptor | ENCODES a protein that exhibits identical protein binding (ortholog); thyrotropin-releasing hormone receptor activity (ortholog); INVOLVED IN positive regulation of cytosolic calcium ion concentration (ortholog); positive regulation of protein-containing complex assembly (ortholog); ASSOCIATED WITH congenital hypothyroidism (ortholog); congenital nongoitrous hypothyroidism 7 (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog) | 13 | 9642565 | 9681778 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12597490 | Trhr | thyrotropin releasing hormone receptor | ENCODES a protein that exhibits identical protein binding (ortholog); thyrotropin-releasing hormone receptor activity (ortholog); INVOLVED IN positive regulation of cytosolic calcium ion concentration (ortholog); positive regulation of protein-containing complex assembly (ortholog); ASSOCIATED WITH congenital hypothyroidism (ortholog); congenital nongoitrous hypothyroidism 7 (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog) | NW_004936470 | 35808569 | 35844062 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18455681 | TRHR | thyrotropin releasing hormone receptor | ENCODES a protein that exhibits identical protein binding (ortholog); thyrotropin-releasing hormone receptor activity (ortholog); INVOLVED IN positive regulation of cytosolic calcium ion concentration (ortholog); positive regulation of protein-containing complex assembly (ortholog); ASSOCIATED WITH congenital hypothyroidism (ortholog); congenital nongoitrous hypothyroidism 7 (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231616 | trhr | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18910924 | Trhr | thyrotropin releasing hormone receptor | ENCODES a protein that exhibits identical protein binding (ortholog); thyrotropin-releasing hormone receptor activity (ortholog); INVOLVED IN positive regulation of cytosolic calcium ion concentration (ortholog); positive regulation of protein-containing complex assembly (ortholog); ASSOCIATED WITH congenital hypothyroidism (ortholog); congenital nongoitrous hypothyroidism 7 (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog) | | | | Naked Mole-Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626008548 | Trhr | thyrotropin releasing hormone receptor | ENCODES a protein that exhibits identical protein binding (ortholog); thyrotropin-releasing hormone receptor activity (ortholog); INVOLVED IN positive regulation of cytosolic calcium ion concentration (ortholog); positive regulation of protein-containing complex assembly (ortholog); ASSOCIATED WITH congenital hypothyroidism (ortholog); congenital nongoitrous hypothyroidism 7 (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog) | | | | Black Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14114907 | TRHR | thyrotropin releasing hormone receptor | ENCODES a protein that exhibits identical protein binding (ortholog); thyrotropin-releasing hormone receptor activity (ortholog); INVOLVED IN positive regulation of cytosolic calcium ion concentration (ortholog); positive regulation of protein-containing complex assembly (ortholog); ASSOCIATED WITH congenital hypothyroidism (ortholog); congenital nongoitrous hypothyroidism 7 (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog) | | | | Pig | 26 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14388049 | trhr-1 | | | | | | Roundworm | | symbol | gene, null |
| 155231615 | trhr.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257937 | trhr.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 732529 | Trhr2 | thyrotropin releasing hormone receptor 2 | Predicted to enable thyrotropin-releasing hormone receptor activity. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in neuronal cell body and plasma membrane. Is expressed in brain; cap mesenchyme; embryo; and female associ ated reproductive structure. [provided by Alliance of Genome Resources, Jul 2025] | 8 | 123082804 | 123089725 | Mouse | 26 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 284504489 | trhr2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 287729335 | trhr3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 329330985 | trhr2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626182975 | trhr2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626469611 | trhr3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 329332837 | trhr3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 621262 | Mlnr | motilin receptor | ENCODES a protein that exhibits thyrotropin-releasing hormone receptor activity; INVOLVED IN G protein-coupled receptor signaling pathway (inferred); signal transduction (inferred); PARTICIPATES IN calcium/calcium-mediated signaling pathway; FOUND IN neuronal cell body; INTERACTS WITH 2,2',4,4'-Tetr abromodiphenyl ether; 6-propyl-2-thiouracil; acrylamide | 19 | 67317269 | 67340508 | Rat | 23 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1620635 | Gpr139 | G protein-coupled receptor 139 | Enables identical protein binding activity and neuropeptide receptor activity. Involved in G protein-coupled receptor signaling pathway. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in seve ral structures, including ileum; liver; male reproductive gland or organ; nervous system; and spleen. Orthologous to human GPR139 (G protein-coupled receptor 139). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 118739970 | 118783761 | Mouse | 37 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |