Mlnr (motilin receptor) - Rat Genome Database

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Gene: Mlnr (motilin receptor) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mlnr
Name: motilin receptor
RGD ID: 621262
Description: Enables thyrotropin-releasing hormone receptor activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway. Located in neuronal cell body; PARTICIPATES IN calcium/calcium-mediated signaling pathway; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: thyrotropin releasing hormone receptor 2; Trhr2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,317,269 - 67,340,508 (-)NCBIGRCr8
mRatBN7.21950,413,570 - 50,422,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,413,580 - 50,418,770 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1957,210,325 - 57,214,254 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,889,579 - 57,893,508 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,108,943 - 60,112,872 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,176,617 - 55,183,562 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,176,258 - 55,183,557 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01965,888,496 - 65,892,205 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,624,099 - 52,627,808 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11952,627,916 - 52,632,887 (-)NCBI
Celera1949,654,323 - 49,658,096 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning and characterization of a cDNA encoding a novel subtype of rat thyrotropin-releasing hormone receptor. Cao J, etal., J Biol Chem 1998 Nov 27;273(48):32281-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake. Gotoh K, etal., J Neurochem. 2007 Nov;103(3):1102-10. Epub 2007 Aug 30.
4. Cloning and characterization of a new subtype of thyrotropin-releasing hormone receptors. Itadani H, etal., Biochem Biophys Res Commun 1998 Sep 8;250(1):68-71.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12393857   PMID:15944919   PMID:18795335  


Genomics

Variants

.
Variants in Mlnr
67 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:138
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000017317
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 5 13 60 17 19 12 5 12 5 49 21 54 8 31 7

Sequence


Ensembl Acc Id: ENSRNOT00000017317   ⟹   ENSRNOP00000017317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1950,413,580 - 50,418,770 (-)Ensembl
Rnor_6.0 Ensembl1955,176,258 - 55,183,557 (-)Ensembl
RefSeq Acc Id: NM_181364   ⟹   NP_852029
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,323,196 - 67,327,125 (-)NCBI
mRatBN7.21950,414,643 - 50,418,572 (-)NCBI
Rnor_6.01955,177,690 - 55,181,399 (-)NCBI
Rnor_5.01965,888,496 - 65,892,205 (-)NCBI
RGSC_v3.41952,624,099 - 52,627,808 (-)RGD
Celera1949,654,323 - 49,658,096 (-)RGD
Sequence:
RefSeq Acc Id: XM_017601176   ⟹   XP_017456665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,317,269 - 67,340,508 (-)NCBI
mRatBN7.21950,413,570 - 50,422,842 (-)NCBI
Rnor_6.01955,176,617 - 55,183,562 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063277788   ⟹   XP_063133858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,317,269 - 67,340,508 (-)NCBI
RefSeq Acc Id: XR_010059959
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,317,269 - 67,340,508 (-)NCBI
RefSeq Acc Id: NP_852029   ⟸   NM_181364
- UniProtKB: Q9R297 (UniProtKB/TrEMBL),   A6IZR3 (UniProtKB/TrEMBL),   O88820 (UniProtKB/TrEMBL),   Q9QWW3 (UniProtKB/TrEMBL),   F7ER42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456665   ⟸   XM_017601176
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000017317   ⟸   ENSRNOT00000017317
RefSeq Acc Id: XP_063133858   ⟸   XM_063277788
- Peptide Label: isoform X1
- UniProtKB: O88820 (UniProtKB/TrEMBL),   Q9QWW3 (UniProtKB/TrEMBL),   A6IZR3 (UniProtKB/TrEMBL),   F7ER42 (UniProtKB/TrEMBL),   Q9R297 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R297-F1-model_v2 AlphaFold Q9R297 1-352 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621262 AgrOrtholog
BioCyc Gene G2FUF-5401 BioCyc
Ensembl Genes ENSRNOG00000012789 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017317 ENTREZGENE
  ENSRNOT00000017317.5 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  TRH_rcpt_1 UniProtKB/TrEMBL
KEGG Report rno:252859 UniProtKB/TrEMBL
NCBI Gene 252859 ENTREZGENE
PANTHER PTHR46061 UniProtKB/TrEMBL
  THYROLIBERIN RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Mlnr PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  TRHRECEPTOR2 UniProtKB/TrEMBL
  TRHRFAMILY UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012789 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6IZR3 ENTREZGENE, UniProtKB/TrEMBL
  F7ER42 ENTREZGENE, UniProtKB/TrEMBL
  O88820 ENTREZGENE, UniProtKB/TrEMBL
  Q9QWW3 ENTREZGENE, UniProtKB/TrEMBL
  Q9R297 ENTREZGENE
UniProt Secondary Q9R297 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-18 Mlnr  motilin receptor  Trhr2  thyrotropin releasing hormone receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-03-17 Trhr2  thyrotropin releasing hormone receptor 2  Mlnr  motilin receptor  Name and Symbol changed 629549 APPROVED
2014-12-11 Mlnr  motilin receptor  Trhr2  thyrotropin releasing hormone receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Trhr2  thyrotropin releasing hormone receptor 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Trhr2  thyrotropin releasing hormone receptor 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is brain-specific 634429