| 1312746 | TNFRSF25 | TNF receptor superfamily member 25 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008] | 1 | 6460786 | 6466173 | Human | 160 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1312747 | Tnfrsf25 | tumor necrosis factor receptor superfamily, member 25 | Predicted to be active in plasma membrane. Orthologous to human TNFRSF25 (TNF receptor superfamily member 25). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 152199985 | 152204568 | Mouse | 156 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1598206 | Tnfrsf25 | TNF receptor superfamily member 25 | INVOLVED IN apoptotic process (inferred); signal transduction (inferred); PARTICIPATES IN cytokine mediated signaling pathway; FOUND IN plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 167904377 | 167909052 | Rat | 148 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 9012408 | Tnfrsf25 | TNF receptor superfamily member 25 | FOUND IN plasma membrane (ortholog) | NW_004955486 | 6121906 | 6127060 | Chinchilla | 1 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11976340 | TNFRSF25 | TNF receptor superfamily member 25 | INVOLVED IN apoptotic process (inferred); signal transduction (inferred); FOUND IN plasma membrane (inferred) | 1 | 5222680 | 5228211 | Bonobo | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12375763 | TNFRSF25 | TNF receptor superfamily member 25 | INVOLVED IN apoptotic process (inferred); signal transduction (inferred); FOUND IN plasma membrane (inferred) | 5 | 60316473 | 60321299 | Dog | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12544973 | Tnfrsf25 | TNF receptor superfamily member 25 | INVOLVED IN apoptotic process (inferred); signal transduction (inferred); FOUND IN plasma membrane (inferred) | NW_004936623 | 1249979 | 1254273 | Squirrel | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13956845 | TNFRSF25 | TNF receptor superfamily member 25 | INVOLVED IN apoptotic process (inferred); signal transduction (inferred); FOUND IN plasma membrane (inferred) | | | | Pig | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625842450 | Tnfrsf25 | TNF receptor superfamily member 25 | FOUND IN plasma membrane (ortholog) | | | | Black Rat | 1 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922695 | Tnfrsf25 | TNF receptor superfamily member 25 | FOUND IN plasma membrane (inferred) | | | | Naked Mole-Rat | 1 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18480109 | TNFRSF25 | TNF receptor superfamily member 25 | INVOLVED IN apoptotic process (inferred); signal transduction (inferred); FOUND IN plasma membrane (inferred) | | | | Green Monkey | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18928309 | LOC101709705 | tumor necrosis factor receptor superfamily member 25 | INVOLVED IN signal transduction (inferred); FOUND IN plasma membrane (inferred) | | | | Naked Mole-Rat | 2 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1345195 | FADD | Fas associated via death domain | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25 NFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008] | 11 | 70203296 | 70207390 | Human | 461 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 737096 | TNFSF15 | TNF superfamily member 15 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] | 9 | 114784635 | 114806039 | Human | 168 | description | gene, protein-coding, REVIEWED [RefSeq] |
