| 1345557 | TIAL1 | TIA1 cytotoxic granule associated RNA binding protein like 1 | The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptos is. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008] | 10 | 119573465 | 119596964 | Human | 140 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557567 | Tial1 | Tia1 cytotoxic granule-associated RNA binding protein-like 1 | Enables mRNA 3'-UTR AU-rich region binding activity. Acts upstream of or within germ cell development; positive regulation of stem cell proliferation; and stem cell division. Located in cytoplasmic stress granule and nucleus. Is expressed in several structures, including branchial arch; central nerv ous system; primordial germ cell; sensory organ; and testis. Orthologous to human TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 128041496 | 128063450 | Mouse | 149 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1595845 | Tial1 | Tia1 cytotoxic granule-associated RNA binding protein-like 1 | ENCODES a protein that exhibits mRNA 3'-UTR AU-rich region binding (ortholog); mRNA 3'-UTR binding (ortholog); protein-RNA adaptor activity (ortholog); INVOLVED IN germ cell development (ortholog); negative regulation of cell population proliferation (ortholog); positive regulation of cell populatio n proliferation (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH transient cerebral ischemia; Disease Progression (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasmic stress granule; ribonucleoprotein complex; cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 1 | 192438794 | 192475520 | Rat | 130 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8706553 | Tial1 | TIA1 cytotoxic granule associated RNA binding protein like 1 | ENCODES a protein that exhibits mRNA 3'-UTR AU-rich region binding (ortholog); mRNA 3'-UTR binding (ortholog); protein-RNA adaptor activity (ortholog); INVOLVED IN germ cell development (ortholog); negative regulation of cell population proliferation (ortholog); positive regulation of cell populatio n proliferation (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Disease Progression (ortholog); Experimental Liver Cirrhosis (ortholog); malignant astrocytoma (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic stress granule (ortholog); cytosol (ortholog) | NW_004955551 | 370792 | 395836 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11765015 | TIAL1 | TIA1 cytotoxic granule associated RNA binding protein like 1 | ENCODES a protein that exhibits mRNA 3'-UTR AU-rich region binding (ortholog); INVOLVED IN germ cell development (ortholog); positive regulation of cell population proliferation (ortholog); stem cell division (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Disease Progression (ortho log); Experimental Liver Cirrhosis (ortholog); malignant astrocytoma (ortholog); FOUND IN cytoplasmic stress granule (ortholog); ribonucleoprotein complex (ortholog) | 10 | 116142127 | 116165631 | Bonobo | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12396291 | TIAL1 | TIA1 cytotoxic granule associated RNA binding protein like 1 | ENCODES a protein that exhibits mRNA 3'-UTR AU-rich region binding (ortholog); INVOLVED IN germ cell development (ortholog); positive regulation of cell population proliferation (ortholog); stem cell division (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Disease Progression (ortho log); Experimental Liver Cirrhosis (ortholog); malignant astrocytoma (ortholog); FOUND IN cytoplasmic stress granule (ortholog); ribonucleoprotein complex (ortholog) | 28 | 29729246 | 29750703 | Dog | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12625879 | Tial1 | TIA1 cytotoxic granule associated RNA binding protein like 1 | ENCODES a protein that exhibits DNA binding (inferred); mRNA 3'-UTR AU-rich region binding (inferred); mRNA 3'-UTR binding (inferred); INVOLVED IN germ cell development (ortholog); positive regulation of cell population proliferation (ortholog); stem cell division (ortholog); PARTICIPATES IN spliceo some pathway; ASSOCIATED WITH Disease Progression (ortholog); Experimental Liver Cirrhosis (ortholog); malignant astrocytoma (ortholog); FOUND IN cytoplasmic stress granule (ortholog); ribonucleoprotein complex (ortholog) | NW_004936486 | 8925819 | 8947872 | Squirrel | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626103429 | Tial1 | TIA1 cytotoxic granule associated RNA binding protein like 1 | ENCODES a protein that exhibits mRNA 3'-UTR AU-rich region binding (ortholog); mRNA 3'-UTR binding (ortholog); protein-RNA adaptor activity (ortholog); INVOLVED IN germ cell development (ortholog); negative regulation of cell population proliferation (ortholog); positive regulation of cell populatio n proliferation (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Disease Progression (ortholog); Experimental Liver Cirrhosis (ortholog); malignant astrocytoma (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic stress granule (ortholog); cytosol (ortholog) | | | | Black Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626178260 | tial1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18563876 | TIAL1 | TIA1 cytotoxic granule associated RNA binding protein like 1 | ENCODES a protein that exhibits mRNA 3'-UTR AU-rich region binding (ortholog); INVOLVED IN germ cell development (ortholog); positive regulation of cell population proliferation (ortholog); stem cell division (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Disease Progression (ortho log); Experimental Liver Cirrhosis (ortholog); malignant astrocytoma (ortholog); FOUND IN cytoplasmic stress granule (ortholog); ribonucleoprotein complex (ortholog) | | | | Green Monkey | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626186072 | tial1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18916372 | Tial1 | TIA1 cytotoxic granule associated RNA binding protein like 1 | ENCODES a protein that exhibits DNA binding (inferred); mRNA 3'-UTR AU-rich region binding (inferred); mRNA 3'-UTR binding (inferred); INVOLVED IN germ cell development (ortholog); positive regulation of cell population proliferation (ortholog); stem cell division (ortholog); PARTICIPATES IN spliceo some pathway; ASSOCIATED WITH Disease Progression (ortholog); Experimental Liver Cirrhosis (ortholog); malignant astrocytoma (ortholog); FOUND IN cytoplasmic stress granule (ortholog); ribonucleoprotein complex (ortholog) | | | | Naked Mole-Rat | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13965322 | TIAL1 | TIA1 cytotoxic granule associated RNA binding protein like 1 | ENCODES a protein that exhibits mRNA 3'-UTR AU-rich region binding (ortholog); INVOLVED IN germ cell development (ortholog); positive regulation of cell population proliferation (ortholog); stem cell division (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Disease Progression (ortho log); Experimental Liver Cirrhosis (ortholog); malignant astrocytoma (ortholog); FOUND IN cytoplasmic stress granule (ortholog); ribonucleoprotein complex (ortholog) | | | | Pig | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626175652 | tial1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 616390070 | tial1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 616390097 | tial1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 598153259 | tial1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2319362 | Tial1-ps1 | Tia1 cytotoxic granule-associated RNA binding protein-like 1, pseudogene 1 | | 8 | 12418808 | 12419568 | Rat | | symbol , old_gene_name , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16565465 | TIAL1P1 | TIAL1 pseudogene | | 6 | 51385301 | 51385826 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |