| 1359268 | Snip1 | Smad nuclear interacting protein 1 | ENCODES a protein that exhibits transcription regulator inhibitor activity (ortholog); INVOLVED IN miRNA processing (ortholog); mRNA splicing, via spliceosome (ortholog); negative regulation of canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ARTERIAL DISSECTION (ortholog); benign epilepsy with centrotemporal spikes (ortholog); Psychomotor Retardation, Epilepsy, and Craniofacial Dysmorphism (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); U2-type precatalytic spliceosome (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin | 5 | 142613028 | 142620502 | Rat | 103 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1550612 | Snip1 | Smad nuclear interacting protein 1 | Enables transcription regulator inhibitor activity. Involved in negative regulation of canonical NF-kappaB signal transduction. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Is active in nucleus. Is expressed in several structures, including branchial arch; ce rebral cortex; gut epithelium; metanephros; and sensory organ. Orthologous to human SNIP1 (Smad nuclear interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 124960465 | 124967836 | Mouse | 121 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605941 | SNIP1 | Smad nuclear interacting protein 1 | This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signa ling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012] | 1 | 37534449 | 37554293 | Human | 143 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9034594 | Snip1 | Smad nuclear interacting protein 1 | ENCODES a protein that exhibits transcription regulator inhibitor activity (ortholog); INVOLVED IN miRNA processing (ortholog); mRNA splicing, via spliceosome (ortholog); negative regulation of canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ARTERIAL DISSECTION (ortholog); benign epilepsy with centrotemporal spikes (ortholog); Psychomotor Retardation, Epilepsy, and Craniofacial Dysmorphism (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); spliceosomal complex (ortholog) | NW_004955452 | 15352080 | 15365545 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11735707 | SNIP1 | Smad nuclear interacting protein 1 | ENCODES a protein that exhibits transcription regulator inhibitor activity (inferred); INVOLVED IN miRNA processing (inferred); mRNA processing (inferred); mRNA splicing, via spliceosome (inferred); ASSOCIATED WITH ARTERIAL DISSECTION (ortholog); benign epilepsy with centrotemporal spikes (ortholog) ; Psychomotor Retardation, Epilepsy, and Craniofacial Dysmorphism (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); spliceosomal complex (inferred) | 1 | 36807488 | 36827347 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12347864 | SNIP1 | Smad nuclear interacting protein 1 | ENCODES a protein that exhibits transcription regulator inhibitor activity (inferred); INVOLVED IN miRNA processing (inferred); mRNA processing (inferred); mRNA splicing, via spliceosome (inferred); ASSOCIATED WITH ARTERIAL DISSECTION (ortholog); benign epilepsy with centrotemporal spikes (ortholog) ; Psychomotor Retardation, Epilepsy, and Craniofacial Dysmorphism (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); spliceosomal complex (inferred) | 15 | 4924035 | 4934565 | Dog | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12714453 | Snip1 | Smad nuclear interacting protein 1 | ENCODES a protein that exhibits transcription regulator inhibitor activity (inferred); INVOLVED IN miRNA processing (inferred); mRNA processing (inferred); mRNA splicing, via spliceosome (inferred); ASSOCIATED WITH ARTERIAL DISSECTION (ortholog); benign epilepsy with centrotemporal spikes (ortholog) ; Psychomotor Retardation, Epilepsy, and Craniofacial Dysmorphism (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); spliceosomal complex (inferred) | NW_004936474 | 19760653 | 19778224 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240467 | snip1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18924886 | Snip1 | Smad nuclear interacting protein 1 | ENCODES a protein that exhibits transcription regulator inhibitor activity (ortholog); INVOLVED IN miRNA processing (ortholog); mRNA splicing, via spliceosome (ortholog); negative regulation of canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ARTERIAL DISSECTION (ortholog); benign epilepsy with centrotemporal spikes (ortholog); Psychomotor Retardation, Epilepsy, and Craniofacial Dysmorphism (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); U12-type catalytic step 2 spliceosome (ortholog) | | | | Naked Mole-Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20865683 | SNIP1 | Smad nuclear interacting protein 1 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 13863276 | SNIP1 | Smad nuclear interacting protein 1 | ENCODES a protein that exhibits transcription regulator inhibitor activity (inferred); INVOLVED IN miRNA processing (inferred); mRNA processing (inferred); mRNA splicing, via spliceosome (inferred); ASSOCIATED WITH ARTERIAL DISSECTION (ortholog); benign epilepsy with centrotemporal spikes (ortholog) ; Psychomotor Retardation, Epilepsy, and Craniofacial Dysmorphism (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); spliceosomal complex (inferred) | | | | Pig | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18694101 | SNIP1 | Smad nuclear interacting protein 1 | ENCODES a protein that exhibits transcription regulator inhibitor activity (inferred); INVOLVED IN miRNA processing (inferred); mRNA processing (inferred); mRNA splicing, via spliceosome (inferred); ASSOCIATED WITH ARTERIAL DISSECTION (ortholog); benign epilepsy with centrotemporal spikes (ortholog) ; Psychomotor Retardation, Epilepsy, and Craniofacial Dysmorphism (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); spliceosomal complex (inferred) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626124374 | Snip1 | Smad nuclear interacting protein 1 | ENCODES a protein that exhibits transcription regulator inhibitor activity (ortholog); INVOLVED IN miRNA processing (ortholog); mRNA splicing, via spliceosome (ortholog); negative regulation of canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ARTERIAL DISSECTION (ortholog); benign epilepsy with centrotemporal spikes (ortholog); Psychomotor Retardation, Epilepsy, and Craniofacial Dysmorphism (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); spliceosomal complex (ortholog) | | | | Black Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240468 | snip1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243420 | snip1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 41276740 | Snip1-ps2 | Smad nuclear interacting protein 1, pseudogene 2 | | 15 | 20632382 | 20648717 | Rat | | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 2299009 | BCAR4 | breast cancer anti-estrogen resistance 4 | This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2015] | 16 | 11819830 | 11828832 | Human | 4 | description | gene, ncrna, VALIDATED [RefSeq] |