| 3715 | Slc6a3 | solute carrier family 6 member 3 | ENCODES a protein that exhibits amine binding; dopamine:sodium symporter activity; heterocyclic compound binding; INVOLVED IN dopamine transport; response to cAMP; response to ethanol; PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacody namics pathway; ASSOCIATED WITH heroin dependence; high grade glioma; hyperprolactinemia; FOUND IN dopaminergic synapse; neuron projection; plasma membrane; INTERACTS WITH (S)-amphetamine; (S)-naringenin; (S)-nicotine | 1 | 31537990 | 31578962 | Rat | 574 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 11315 | Slc6a3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Enables dopamine binding activity; dopamine:sodium symporter activity; and neurotransmitter transmembrane transporter activity. Involved in dopamine uptake; hyaloid vascular plexus regression; and neurotransmitter uptake. Acts upstream of or within several processes, including dopamine metabolic pro cess; lactation; and prepulse inhibition. Located in axon terminus and cell surface. Is expressed in genitourinary system; nervous system; spleen; and submandibular gland. Used to study Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and schizophrenia. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; classic dopamine transporter deficiency syndrome; mild cognitive impairment; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 73684270 | 73726791 | Mouse | 844 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 733809 | SLC6A3 | solute carrier family 6 member 3 | This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in t he number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009] | 5 | 1392794 | 1445440 | Human | 653 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8775071 | Slc6a3 | solute carrier family 6 member 3 | ENCODES a protein that exhibits amine binding (ortholog); dopamine binding (ortholog); dopamine:sodium symporter activity (ortholog); INVOLVED IN adenohypophysis development (ortholog); cognition (ortholog); dopamine biosynthetic process (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathwa y; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alcohol Withdrawal Delirium (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell surface (ortholog) | NW_004955504 | 721470 | 747553 | Chinchilla | 152 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12228863 | SLC6A3 | solute carrier family 6 member 3 | ENCODES a protein that exhibits amine binding (ortholog); dopamine:sodium symporter activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN adenohypophysis development (ortholog); cognition (ortholog); dopamine biosynthetic process (ortholog); PARTICIPATES IN alfentanil pharmacody namics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alcohol Withdrawal Delirium (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN dopaminergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic membrane (ortholog) | 34 | 11209118 | 11245456 | Dog | 153 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12452838 | Slc6a3 | solute carrier family 6 member 3 | ENCODES a protein that exhibits amine binding (ortholog); dopamine:sodium symporter activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN adenohypophysis development (ortholog); cognition (ortholog); dopamine biosynthetic process (ortholog); PARTICIPATES IN alfentanil pharmacody namics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alcohol Withdrawal Delirium (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN dopaminergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic membrane (ortholog) | NW_004936815 | 359775 | 400690 | Squirrel | 151 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18674314 | SLC6A3 | solute carrier family 6 member 3 | ENCODES a protein that exhibits amine binding (ortholog); dopamine:sodium symporter activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN adenohypophysis development (ortholog); cognition (ortholog); dopamine biosynthetic process (ortholog); PARTICIPATES IN alfentanil pharmacody namics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alcohol Withdrawal Delirium (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN dopaminergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic membrane (ortholog) | | | | Green Monkey | 152 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18905138 | Slc6a3 | solute carrier family 6 member 3 | ENCODES a protein that exhibits amine binding (ortholog); dopamine binding (ortholog); dopamine:sodium symporter activity (ortholog); INVOLVED IN adenohypophysis development (ortholog); cognition (ortholog); dopamine biosynthetic process (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathwa y; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alcohol Withdrawal Delirium (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN axon terminus (ortholog); cell surface (ortholog); dopaminergic synapse (ortholog) | | | | Naked Mole-Rat | 151 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 402525790 | SLC6A3 | solute carrier family 6 member 3 | ENCODES a protein that exhibits amine binding (ortholog); dopamine:sodium symporter activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN adenohypophysis development (ortholog); cognition (ortholog); dopamine biosynthetic process (ortholog); PARTICIPATES IN alfentanil pharmacody namics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alcohol Withdrawal Delirium (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN dopaminergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic membrane (ortholog) | | | | Bonobo | 152 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242249 | slc6a3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14277831 | SLC6A3 | solute carrier family 6 member 3 | ENCODES a protein that exhibits amine binding (ortholog); dopamine:sodium symporter activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN adenohypophysis development (ortholog); cognition (ortholog); dopamine biosynthetic process (ortholog); PARTICIPATES IN alfentanil pharmacody namics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alcohol Withdrawal Delirium (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN dopaminergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic membrane (ortholog) | | | | Pig | 153 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242248 | slc6a3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 126925197 | Slc6a3m1Span | solute carrier family 6 member 3; ENU induced mutant 1, Span | This allele was identified in the N-ethyl-N-nitrosourea (ENU)-driven target-selected mutagenesis screen. A point mutation in the Slc6a3 (DAT) coding sequence (exon 3) with a T/G transversion at nucleotide position 471 was identified in a male rat. This nucleotid e exchange leads to substitution of an asparagine amino acid residue by a lysine residue at position 157 (N157K) in the SLC6A3 (DAT) protein, which introduces new positive charge into the amino acid sequence. | | | | Rat | | symbol , description | gene, allele |