Slc6a3 (solute carrier family 6 member 3) - Rat Genome Database

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Gene: Slc6a3 (solute carrier family 6 member 3) Heterocephalus glaber
Analyze
Symbol: Slc6a3
Name: solute carrier family 6 member 3
RGD ID: 18905138
Description: ENCODES a protein that exhibits amine binding (ortholog); dopamine binding (ortholog); dopamine:sodium symporter activity (ortholog); INVOLVED IN adenohypophysis development (ortholog); cognition (ortholog); dopamine biosynthetic process (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alcohol Withdrawal Delirium (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN axon terminus (ortholog); cell surface (ortholog); dopaminergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium-dependent dopamine transporter; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624751694,099 - 719,465 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624751694,165 - 720,287 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Slc6a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624751694,099 - 719,465 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624751694,165 - 720,287 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SLC6A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3851,392,794 - 1,445,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl51,392,794 - 1,445,440 (-)EnsemblGRCh38hg38GRCh38
GRCh3751,392,909 - 1,445,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,445,909 - 1,498,538 (-)NCBINCBI36Build 36hg18NCBI36
Build 3451,445,908 - 1,498,543NCBI
Celera51,429,610 - 1,484,220 (-)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef51,373,680 - 1,426,892 (-)NCBIHuRef
CHM1_151,392,820 - 1,445,528 (-)NCBICHM1_1
T2T-CHM13v2.051,303,172 - 1,357,405 (-)NCBIT2T-CHM13v2.0
Slc6a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391373,684,270 - 73,726,791 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1373,684,866 - 73,726,791 (+)EnsemblGRCm39 Ensembl
GRCm381373,536,128 - 73,578,672 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1373,536,747 - 73,578,672 (+)EnsemblGRCm38mm10GRCm38
MGSCv371373,674,195 - 73,716,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361374,002,749 - 74,044,674 (+)NCBIMGSCv36mm8
Celera1375,865,546 - 75,907,463 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.1NCBI
Slc6a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,537,990 - 31,578,962 (-)NCBIGRCr8
mRatBN7.2129,709,443 - 29,750,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,709,443 - 29,750,413 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,510,573 - 29,551,545 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,510,418 - 35,551,390 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,711,198 - 29,752,170 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0132,323,011 - 32,363,983 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,321,580 - 32,363,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,745,060 - 33,788,878 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,516,568 - 30,557,540 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1130,518,078 - 30,558,861 (-)NCBI
Celera128,357,426 - 28,397,883 (-)NCBICelera
Cytogenetic Map1p11NCBI
Slc6a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955504721,429 - 747,630 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955504721,470 - 747,553 (-)NCBIChiLan1.0ChiLan1.0
SLC6A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v241,659,752 - 1,712,599 (-)NCBINHGRI_mPanPan1-v2
PanPan1.1 Ensembl51,437,567 - 1,488,829 (-)Ensemblpanpan1.1panPan2
SLC6A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,209,118 - 11,245,456 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,210,939 - 11,246,742 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3415,719,083 - 15,755,282 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03411,109,747 - 11,147,167 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,109,762 - 11,147,159 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,160,852 - 11,196,981 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,139,913 - 11,176,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03411,350,821 - 11,387,021 (+)NCBIUU_Cfam_GSD_1.0
Slc6a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,198,128 - 244,239,922 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936815359,775 - 400,690 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936815359,775 - 400,690 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,186,108 - 79,220,297 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11679,186,114 - 79,220,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21685,853,611 - 85,887,787 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.141,209,013 - 1,258,797 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl41,209,019 - 1,258,866 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605435,775,947 - 35,824,591 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000008448   ⟹   ENSHGLP00000008359
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624751694,099 - 719,465 (-)Ensembl
RefSeq Acc Id: XM_004845138   ⟹   XP_004845195
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624751694,165 - 720,287 (-)NCBI
RefSeq Acc Id: XM_021258585   ⟹   XP_021114244
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624751694,165 - 719,541 (-)NCBI
RefSeq Acc Id: XM_021258586   ⟹   XP_021114245
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624751694,165 - 717,768 (-)NCBI
RefSeq Acc Id: XM_021258587   ⟹   XP_021114246
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624751694,165 - 717,768 (-)NCBI
RefSeq Acc Id: XM_021258588   ⟹   XP_021114247
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624751694,165 - 717,768 (-)NCBI
RefSeq Acc Id: XM_021258589   ⟹   XP_021114248
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624751694,165 - 717,768 (-)NCBI
RefSeq Acc Id: XM_021258590   ⟹   XP_021114249
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624751694,165 - 717,768 (-)NCBI
RefSeq Acc Id: XM_021258591   ⟹   XP_021114250
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624751694,165 - 717,768 (-)NCBI
RefSeq Acc Id: XP_004845195   ⟸   XM_004845138
- Peptide Label: isoform X1
- UniProtKB: G5BPI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114244   ⟸   XM_021258585
- Peptide Label: isoform X1
- UniProtKB: G5BPI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114245   ⟸   XM_021258586
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021114250   ⟸   XM_021258591
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021114249   ⟸   XM_021258590
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021114248   ⟸   XM_021258589
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021114247   ⟸   XM_021258588
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021114246   ⟸   XM_021258587
- Peptide Label: isoform X2
Ensembl Acc Id: ENSHGLP00000008359   ⟸   ENSHGLT00000008448


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006047 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000008448 ENTREZGENE
InterPro Na/ntran_symport UniProtKB/TrEMBL
  Na/ntran_symport_dopamine UniProtKB/TrEMBL
  SNS_sf UniProtKB/TrEMBL
NCBI Gene Slc6a3 ENTREZGENE
PANTHER SODIUM-DEPENDENT DOPAMINE TRANSPORTER UniProtKB/TrEMBL
  SODIUM/CHLORIDE DEPENDENT TRANSPORTER UniProtKB/TrEMBL
Pfam SNF UniProtKB/TrEMBL
PRINTS DOPTRANSPORT UniProtKB/TrEMBL
  NANEUSMPORT UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_3 UniProtKB/TrEMBL
Superfamily-SCOP SNF-like UniProtKB/TrEMBL
UniProt A0AAX6T077_HETGA UniProtKB/TrEMBL
  A0AAX6T2T8_HETGA UniProtKB/TrEMBL
  G5BPI4 ENTREZGENE, UniProtKB/TrEMBL