| 68364 | Sigmar1 | sigma non-opioid intracellular receptor 1 | ENCODES a protein that exhibits G protein-coupled opioid receptor activity; identical protein binding (ortholog); mu-type opioid receptor binding (ortholog); INVOLVED IN conditioned place preference; cyclooxygenase pathway; negative regulation of neuron apoptotic process; ASSOCIATED WITH alcohol dep endence; diabetic neuropathy; post-traumatic stress disorder; FOUND IN axon; cytoplasm; dendrite; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl | 5 | 61700021 | 61702799 | Rat | 218 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 68519 | SIGMAR1 | sigma non-opioid intracellular receptor 1 | This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013] | 9 | 34634722 | 34637787 | Human | 319 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 68520 | Sigmar1 | sigma non-opioid intracellular receptor 1 | This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regul ating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013] | 4 | 41738493 | 41741359 | Mouse | 241 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8865229 | Sigmar1 | sigma non-opioid intracellular receptor 1 | ENCODES a protein that exhibits G protein-coupled opioid receptor activity (ortholog); identical protein binding (ortholog); mu-type opioid receptor binding (ortholog); INVOLVED IN conditioned place preference (ortholog); cyclooxygenase pathway (ortholog); negative regulation of neuron apoptotic pro cess (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amnestic disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); dendrite (ortholog) | NW_004955472 | 1493896 | 1496377 | Chinchilla | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11838431 | SIGMAR1 | sigma non-opioid intracellular receptor 1 | ENCODES a protein that exhibits G protein-coupled opioid receptor activity (ortholog); identical protein binding (ortholog); mu-type opioid receptor binding (ortholog); INVOLVED IN conditioned place preference (ortholog); cyclooxygenase pathway (ortholog); negative regulation of neuron apoptotic pro cess (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amnestic disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); dendrite (ortholog) | 9 | 34471362 | 34474459 | Bonobo | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12286348 | SIGMAR1 | sigma non-opioid intracellular receptor 1 | ENCODES a protein that exhibits G protein-coupled opioid receptor activity (ortholog); identical protein binding (ortholog); mu-type opioid receptor binding (ortholog); INVOLVED IN conditioned place preference (ortholog); cyclooxygenase pathway (ortholog); negative regulation of neuron apoptotic pro cess (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amnestic disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); dendrite (ortholog) | 11 | 51310672 | 51313426 | Dog | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12444132 | Sigmar1 | sigma non-opioid intracellular receptor 1 | ENCODES a protein that exhibits G protein-coupled opioid receptor activity (ortholog); identical protein binding (ortholog); mu-type opioid receptor binding (ortholog); INVOLVED IN conditioned place preference (ortholog); cyclooxygenase pathway (ortholog); negative regulation of neuron apoptotic pro cess (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amnestic disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); dendrite (ortholog) | NW_004936524 | 2717885 | 2720874 | Squirrel | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13845215 | SIGMAR1 | sigma non-opioid intracellular receptor 1 | ENCODES a protein that exhibits G protein-coupled opioid receptor activity (ortholog); identical protein binding (ortholog); mu-type opioid receptor binding (ortholog); INVOLVED IN conditioned place preference (ortholog); cyclooxygenase pathway (ortholog); negative regulation of neuron apoptotic pro cess (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amnestic disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); dendrite (ortholog) | | | | Pig | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 598130640 | SIGMAR1 | sigma non-opioid intracellular receptor 1 | ENCODES a protein that exhibits G protein-coupled opioid receptor activity (ortholog); identical protein binding (ortholog); mu-type opioid receptor binding (ortholog); INVOLVED IN conditioned place preference (ortholog); cyclooxygenase pathway (ortholog); negative regulation of neuron apoptotic pro cess (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amnestic disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); dendrite (ortholog) | | | | Green Monkey | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626006560 | Sigmar1 | sigma non-opioid intracellular receptor 1 | ENCODES a protein that exhibits G protein-coupled opioid receptor activity (ortholog); identical protein binding (ortholog); mu-type opioid receptor binding (ortholog); INVOLVED IN conditioned place preference (ortholog); cyclooxygenase pathway (ortholog); negative regulation of neuron apoptotic pro cess (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amnestic disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); dendrite (ortholog) | | | | Black Rat | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259103 | sigmar1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18918137 | Sigmar1 | sigma non-opioid intracellular receptor 1 | ENCODES a protein that exhibits G protein-coupled opioid receptor activity (ortholog); identical protein binding (ortholog); mu-type opioid receptor binding (ortholog); INVOLVED IN conditioned place preference (ortholog); cyclooxygenase pathway (ortholog); negative regulation of neuron apoptotic pro cess (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amnestic disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); dendrite (ortholog) | | | | Naked Mole-Rat | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237908 | sigmar1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 18395184 | ARID3C | AT-rich interaction domain 3C | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN macrophage differentiation (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); FOUND IN cytoplasm (ortholog); memb rane raft (ortholog); nucleus (ortholog) | | | | Green Monkey | 10 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |