Shmt2 Gene Search Result

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16 records found for search term Shmt2

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1308582	Shmt2	serine hydroxymethyltransferase 2	ENCODES a protein that exhibits amino acid binding; glycine hydroxymethyltransferase activity; identical protein binding; INVOLVED IN glycine biosynthetic process; glycine biosynthetic process from L-serine; glycine metabolic process; PARTICIPATES IN folate mediated one-carbon metabolic pathway; gly ... (more) cine metabolic pathway; glycine, serine and threonine metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); lung non-small cell carcinoma (ortholog); neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities (ortholog); FOUND IN mitochondrial inner membrane; mitochondrial matrix; BRISC complex (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene	7	65244247	65249580	Rat	279	symbol , PhenoGen	gene, protein-coding, VALIDATED [RefSeq]
1318437	SHMT2	serine hydroxymethyltransferase 2	This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded pro ... (more) tein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]	12	57229711	57234935	Human	321	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1318438	Shmt2	serine hydroxymethyltransferase 2 (mitochondrial)	Enables glycine hydroxymethyltransferase activity. Involved in several processes, including formate biosynthetic process; regulation of oxidative phosphorylation; and tetrahydrofolate interconversion. Acts upstream of or within dTMP biosynthetic process. Located in mitochondrial inner membrane. Is a ... (more) ctive in mitochondrial matrix and nucleus. Is expressed in several structures, including future brain; hepatic primordium; placenta; skeleton; and submandibular gland primordium. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities. Orthologous to human SHMT2 (serine hydroxymethyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]	10	127352992	127358313	Mouse	313	symbol , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
8997578	Shmt2	serine hydroxymethyltransferase 2	ENCODES a protein that exhibits amino acid binding (ortholog); chromatin binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); INVOLVED IN formate biosynthetic process (ortholog); glycine biosynthetic process (ortholog); glycine biosynthetic process from L-serine (ortholog); PART ... (more) ICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); lung non-small cell carcinoma (ortholog); neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities (ortholog); FOUND IN BRISC complex (ortholog); cytoplasm (ortholog); mitochondrial inner membrane (ortholog)	NW_004955458	4957614	4962691	Chinchilla	78	symbol	gene, protein-coding, MODEL [RefSeq]
11824480	SHMT2	serine hydroxymethyltransferase 2	ENCODES a protein that exhibits amino acid binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glycine biosynthetic process (ortholog); glycine biosynthetic process from L-serine (ortholog); glycine metabolic process (ortholog); ... (more) PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); lung non-small cell carcinoma (ortholog); neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog)	12	31692451	31697727	Bonobo	90	symbol	gene, protein-coding, MODEL [RefSeq]
12413364	SHMT2	serine hydroxymethyltransferase 2	ENCODES a protein that exhibits amino acid binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glycine biosynthetic process (ortholog); glycine biosynthetic process from L-serine (ortholog); glycine metabolic process (ortholog); ... (more) PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); lung non-small cell carcinoma (ortholog); neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog)	10	1357347	1362511	Dog	88	symbol	gene, protein-coding, MODEL [RefSeq]
12466279	Shmt2	serine hydroxymethyltransferase 2	ENCODES a protein that exhibits amino acid binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glycine biosynthetic process (ortholog); glycine biosynthetic process from L-serine (ortholog); glycine metabolic process (ortholog); ... (more) PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); lung non-small cell carcinoma (ortholog); neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog)	NW_004936646	1422844	1427929	Squirrel	90	symbol	gene, protein-coding, MODEL [RefSeq]
18375947	SHMT2	serine hydroxymethyltransferase 2	ENCODES a protein that exhibits amino acid binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glycine biosynthetic process (ortholog); glycine biosynthetic process from L-serine (ortholog); glycine metabolic process (ortholog); ... (more) PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); lung non-small cell carcinoma (ortholog); neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog)				Green Monkey	90	symbol	gene, protein-coding, MODEL [RefSeq]
155230978	shmt2						Tropical Clawed Frog		symbol	gene, null
626124290	Shmt2	serine hydroxymethyltransferase 2	ENCODES a protein that exhibits amino acid binding (ortholog); chromatin binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); INVOLVED IN formate biosynthetic process (ortholog); glycine biosynthetic process (ortholog); glycine biosynthetic process from L-serine (ortholog); PART ... (more) ICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); lung non-small cell carcinoma (ortholog); neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities (ortholog); FOUND IN BRISC complex (ortholog); cytoplasm (ortholog); mitochondrial inner membrane (ortholog)				Black Rat	78	symbol	gene, protein-coding, MODEL [RefSeq]
14224315	SHMT2	serine hydroxymethyltransferase 2	ENCODES a protein that exhibits amino acid binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glycine biosynthetic process (ortholog); glycine biosynthetic process from L-serine (ortholog); glycine metabolic process (ortholog); ... (more) PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); lung non-small cell carcinoma (ortholog); neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog); INTERACTS WITH deoxynivalenol				Pig	91	symbol	gene, protein-coding, MODEL [RefSeq]
18902411	Shmt2	serine hydroxymethyltransferase 2	ENCODES a protein that exhibits amino acid binding (ortholog); chromatin binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); INVOLVED IN formate biosynthetic process (ortholog); glycine biosynthetic process (ortholog); glycine biosynthetic process from L-serine (ortholog); PART ... (more) ICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); lung non-small cell carcinoma (ortholog); neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities (ortholog); FOUND IN BRISC complex (ortholog); mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog)				Naked Mole-Rat	81	symbol	gene, protein-coding, MODEL [RefSeq]
155247492	shmt2.L						African Clawed Frog		symbol	gene, null
155230977	shmt2.S						African Clawed Frog		symbol	gene, null
1598349	Shmt2-ps1	serine hydroxymethyltransferase 2, pseudogene 1		2	181193255	181194596	Rat		symbol , PhenoGen	gene, pseudo, MODEL [RefSeq]
16567978	AC137834.2	novel transcript, antisense to SHMT2					Human		name	gene, lncrna