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Gene: Shmt2 (serine hydroxymethyltransferase 2 (mitochondrial)) Mus musculus
Symbol: Shmt2
Name: serine hydroxymethyltransferase 2 (mitochondrial)
RGD ID: 1318438
Description: Predicted to have several functions, including L-allo-threonine aldolase activity; cation binding activity; and glycine hydroxymethyltransferase activity. Involved in regulation of aerobic respiration; regulation of mitochondrial translation; and regulation of oxidative phosphorylation. Localizes to mitochondrial inner membrane. Is expressed in several structures, including brain; neural retina; placenta; skeleton; and submandibular gland primordium. Orthologous to human SHMT2 (serine hydroxymethyltransferase 2); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2700043D08Rik; AA408223; AA986903; glycine hydroxymethyltransferase; serine hydroxymethyltransferase, mitochondrial; serine methylase; SHMT
Homo sapiens (human) : SHMT2 (serine hydroxymethyltransferase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Shmt2 (serine hydroxymethyltransferase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shmt2 (serine hydroxymethyltransferase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SHMT2 (serine hydroxymethyltransferase 2)
Canis lupus familiaris (dog) : SHMT2 (serine hydroxymethyltransferase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shmt2 (serine hydroxymethyltransferase 2)
Sus scrofa (pig) : SHMT2 (serine hydroxymethyltransferase 2)
Chlorocebus sabaeus (African green monkey) : SHMT2 (serine hydroxymethyltransferase 2)
Heterocephalus glaber (naked mole-rat) : Shmt2 (serine hydroxymethyltransferase 2)
more info ...
Related Pseudogenes: Gm15544  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl10127,517,123 - 127,522,444 (-)EnsemblGRCm38mm10GRCm38
GRCm3810127,517,123 - 127,522,444 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710126,954,195 - 126,959,491 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610126,920,088 - 126,925,384 (-)NCBImm8
Celera10129,908,893 - 129,914,189 (-)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Shmt2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318438
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.