| 1312011 | Shmt1 | serine hydroxymethyltransferase 1 | ENCODES a protein that exhibits amino acid binding; glycine hydroxymethyltransferase activity; identical protein binding; INVOLVED IN glycine biosynthetic process; glycine biosynthetic process from L-serine; glycine metabolic process; PARTICIPATES IN folate mediated one-carbon metabolic pathway; gly cine metabolic pathway; glycine, serine and threonine metabolic pathway; ASSOCIATED WITH Animal Disease Models (ortholog); breast cancer (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol | 10 | 45968959 | 45990341 | Rat | 271 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1323770 | SHMT1 | serine hydroxymethyltransferase 1 | This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine , thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] | 17 | 18327873 | 18363550 | Human | 298 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1323771 | Shmt1 | serine hydroxymethyltransferase 1 (soluble) | Enables glycine hydroxymethyltransferase activity. Involved in tetrahydrofolate interconversion. Acts upstream of or within cellular response to leukemia inhibitory factor and dTMP biosynthetic process. Located in mitochondrion. Is active in nucleus. Is expressed in several structures, including ali mentary system; brain ventricular layer; genitourinary system; liver and biliary system; and skin. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human SHMT1 (serine hydroxymethyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 60679723 | 60702062 | Mouse | 325 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8884960 | Shmt1 | serine hydroxymethyltransferase 1 | ENCODES a protein that exhibits aldehyde-lyase activity (ortholog); amino acid binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); INVOLVED IN 'de novo' pyrimidine nucleobase biosynthetic process (ortholog); cellular response to leukemia inhibitory factor (ortholog); cellular r esponse to tetrahydrofolate (ortholog); PARTICIPATES IN carnitine biosynthetic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; ASSOCIATED WITH Animal Disease Models (ortholog); breast cancer (ortholog); Breast Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog) | NW_004955478 | 10972791 | 11001535 | Chinchilla | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11759008 | SHMT1 | serine hydroxymethyltransferase 1 | ENCODES a protein that exhibits aldehyde-lyase activity (ortholog); amino acid binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); glycine biosynthetic process (ortholog); glycine biosynthetic process from L-serine (ortholog); PARTICIPATES IN carnitine biosynthetic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; ASSOCIATED WITH Animal Disease Models (ortholog); breast cancer (ortholog); COVID-19 (ortholog); FOUND IN nucleus (ortholog) | 17 | 32870949 | 32905690 | Bonobo | 105 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12290979 | SHMT1 | serine hydroxymethyltransferase 1 | ENCODES a protein that exhibits aldehyde-lyase activity (ortholog); amino acid binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); INVOLVED IN 'de novo' pyrimidine nucleobase biosynthetic process (ortholog); cellular response to leukemia inhibitory factor (ortholog); cellular r esponse to tetrahydrofolate (ortholog); PARTICIPATES IN carnitine biosynthetic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; ASSOCIATED WITH Animal Disease Models (ortholog); breast cancer (ortholog); COVID-19 (ortholog); FOUND IN cytosol (ortholog); replication fork (ortholog); INTERACTS WITH clofibrate | 5 | 41221531 | 41248653 | Dog | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12511731 | Shmt1 | serine hydroxymethyltransferase 1 | ENCODES a protein that exhibits aldehyde-lyase activity (ortholog); amino acid binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); glycine biosynthetic process (ortholog); glycine biosynthetic process from L-serine (ortholog); PARTICIPATES IN carnitine biosynthetic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; ASSOCIATED WITH Animal Disease Models (ortholog); breast cancer (ortholog); Breast Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrion (inferred) | NW_004936741 | 1849239 | 1877724 | Squirrel | 93 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866424 | SHMT1 | serine hydroxymethyltransferase 1 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 18415297 | SHMT1 | serine hydroxymethyltransferase 1 | ENCODES a protein that exhibits aldehyde-lyase activity (ortholog); amino acid binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); glycine biosynthetic process (ortholog); glycine biosynthetic process from L-serine (ortholog); PARTICIPATES IN carnitine biosynthetic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; ASSOCIATED WITH Animal Disease Models (ortholog); breast cancer (ortholog); Breast Neoplasms (ortholog); FOUND IN nucleus (ortholog) | | | | Green Monkey | 101 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244671 | shmt1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18932676 | Shmt1 | serine hydroxymethyltransferase 1 | ENCODES a protein that exhibits aldehyde-lyase activity (ortholog); amino acid binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); INVOLVED IN 'de novo' pyrimidine nucleobase biosynthetic process (ortholog); cellular response to leukemia inhibitory factor (ortholog); cellular r esponse to tetrahydrofolate (ortholog); PARTICIPATES IN carnitine biosynthetic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; ASSOCIATED WITH Animal Disease Models (ortholog); breast cancer (ortholog); COVID-19 (ortholog); FOUND IN cytosol (ortholog); replication fork (ortholog) | | | | Naked Mole-Rat | 92 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13961886 | SHMT1 | serine hydroxymethyltransferase 1 | ENCODES a protein that exhibits aldehyde-lyase activity (ortholog); amino acid binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); glycine biosynthetic process (ortholog); glycine biosynthetic process from L-serine (ortholog); PARTICIPATES IN carnitine biosynthetic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; ASSOCIATED WITH Animal Disease Models (ortholog); breast cancer (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred); INTERACTS WITH resveratrol | | | | Pig | 96 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256483 | shmt1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1350866 | SHMT1P1 | SHMT1 pseudogene 1 | | 1 | 43849421 | 43851952 | Human | | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
