SHMT1 (serine hydroxymethyltransferase 1)

Gene: SHMT1 (serine hydroxymethyltransferase 1) Pan paniscus

Analyze

Symbol:

SHMT1

Name:

serine hydroxymethyltransferase 1

RGD ID:

11759008

Description:

ENCODES a protein that exhibits amino acid binding (ortholog); glycine hydroxymethyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); dTMP biosynthetic process (ortholog); glycine biosynthetic process (ortholog); PARTICIPATES IN carnitine biosynthetic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; ASSOCIATED WITH Animal Disease Models (ortholog); autistic disorder (ortholog); breast cancer (ortholog); FOUND IN nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serine hydroxymethyltransferase, cytosolic

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	52,905,330 - 52,940,088 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	57,616,479 - 57,650,574 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	32,870,949 - 32,905,690 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	37,849,206 - 37,884,220 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	37,849,206 - 37,884,220 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

autistic disorder (ISO)

breast cancer (ISO)

Breast Neoplasms (ISO)

common variable immunodeficiency 2 (ISO)

COVID-19 (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

Joubert syndrome 1 (ISO)

lung adenocarcinoma (ISO)

nervous system disease (ISO)

non-Hodgkin lymphoma (ISO)

ovarian cancer (ISO)

Potocki-Lupski syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to leukemia inhibitory factor (IEA,ISO)

cellular response to tetrahydrofolate (IEA)

dTMP biosynthetic process (ISO)

folic acid metabolic process (IEA)

glycine biosynthetic process (ISO)

glycine biosynthetic process from serine (IEA,ISO)

glycine metabolic process (IEA,ISO)

L-serine catabolic process (IEA)

L-serine metabolic process (IEA)

negative regulation of translation (IEA)

one-carbon metabolic process (IEA)

protein homotetramerization (IEA)

purine nucleobase biosynthetic process (IEA)

tetrahydrofolate interconversion (IEA)

tetrahydrofolate metabolic process (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

nucleoplasm (IEA)

nucleus (IEA,ISO)

Molecular Function

amino acid binding (ISO)

cobalt ion binding (IEA)

glycine hydroxymethyltransferase activity (IEA,ISO)

identical protein binding (IEA,ISO)

L-allo-threonine aldolase activity (ISO)

mRNA 5'-UTR binding (IEA)

mRNA regulatory element binding translation repressor activity (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

pyridoxal phosphate binding (IEA,ISO)

serine binding (IEA)

small molecule binding (IEA)

transferase activity (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

carnitine biosynthetic pathway (ISO)

dihydropyrimidine dehydrogenase deficiency pathway (ISO)

dimethylglycine dehydrogenase deficiency pathway (ISO)

folate cycle metabolic pathway (ISO)

folate mediated one-carbon metabolic pathway (ISO)

folate metabolic pathway (ISO)

glycine metabolic pathway (ISO)

glycine N-methyltransferase deficiency pathway (ISO)

glycine, serine and threonine metabolic pathway (ISO)

homocystinuria pathway (ISO)

hypermethioninemia pathway (ISO)

methionine cycle/metabolic pathway (ISO)

methylenetetrahydrofolate reductase deficiency pathway (ISO)

nonketotic hyperglycinemia pathway (ISO)

sarcosinemia pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SHMT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	52,905,330 - 52,940,088 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	57,616,479 - 57,650,574 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	32,870,949 - 32,905,690 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	37,849,206 - 37,884,220 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	37,849,206 - 37,884,220 (+)	Ensembl	panpan1.1		panPan2

SHMT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	18,327,873 - 18,363,550 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	18,327,873 - 18,363,550 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	18,231,187 - 18,266,864 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	18,171,912 - 18,207,581 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	18,171,912 - 18,207,581	NCBI
Celera	17	19,172,258 - 19,207,893 (-)	NCBI		Celera
Cytogenetic Map	17	p11.2	NCBI
HuRef	17	17,984,719 - 18,020,240 (-)	NCBI		HuRef
CHM1_1	17	18,239,946 - 18,275,839 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	18,274,679 - 18,310,356 (-)	NCBI		T2T-CHM13v2.0

Shmt1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	60,679,723 - 60,702,062 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	60,678,930 - 60,702,544 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	60,788,897 - 60,811,265 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	60,788,104 - 60,811,718 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	60,602,399 - 60,624,767 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	61,219,982 - 61,242,350 (-)	NCBI		MGSCv36	mm8
MGSCv36	11	60,605,092 - 60,627,460 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	11	B2	NCBI
cM Map	11	37.84	NCBI

Shmt1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	45,968,959 - 45,990,341 (-)	NCBI		GRCr8
mRatBN7.2	10	45,468,698 - 45,490,833 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	45,468,700 - 45,497,820 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	50,170,944 - 50,199,114 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	49,661,340 - 49,689,514 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	45,164,929 - 45,193,103 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	47,030,813 - 47,059,216 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	47,031,050 - 47,059,216 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	46,802,986 - 46,831,051 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	46,936,605 - 46,964,779 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	46,948,782 - 46,971,713 (-)	NCBI
Celera	10	44,724,251 - 44,752,341 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

Shmt1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955478	10,978,139 - 11,001,202 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955478	10,972,791 - 11,001,535 (+)	NCBI	ChiLan1.0	ChiLan1.0

SHMT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	41,221,531 - 41,248,653 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	41,221,562 - 41,253,166 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	41,361,842 - 41,388,892 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	41,329,062 - 41,356,290 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	41,329,080 - 41,356,907 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	41,296,632 - 41,323,803 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	41,244,262 - 41,272,073 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	41,435,940 - 41,463,042 (+)	NCBI		UU_Cfam_GSD_1.0

Shmt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	60,989,489 - 61,018,689 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936741	1,849,609 - 1,877,727 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936741	1,849,239 - 1,877,724 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SHMT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	60,416,463 - 60,435,450 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	60,414,421 - 60,435,451 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SHMT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	17,371,704 - 17,408,499 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666059	3,494,856 - 3,535,333 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Shmt1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624849	3,114,876 - 3,146,248 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624849	3,108,875 - 3,146,669 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003809772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003809773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008962069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034942295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055101796	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055101797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055101798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055101799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055101800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000036281 ⟹ ENSPPAP00000013608

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	17	37,849,206 - 37,884,220 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000036284 ⟹ ENSPPAP00000013611

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	17	37,849,206 - 37,884,220 (+)	Ensembl

RefSeq Acc Id:

XM_003809772 ⟹ XP_003809820

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	52,905,330 - 52,940,088 (+)	NCBI
NHGRI_mPanPan1	17	57,616,479 - 57,650,574 (+)	NCBI
Mhudiblu_PPA_v0	17	32,870,949 - 32,905,677 (-)	NCBI
PanPan1.1	17	37,849,206 - 37,884,220 (+)	NCBI

Sequence:

show sequence

CGGGGGCGGGGCCAAGCCCAAGCCTGGCGCGCAGGGTGCACCTACCGGAGCTCGAGCGGTCCAG
CGCCAAGTTCGGGGTTTGGGTTGGAGGGGCTGGTCACGTGGCTGGCCCGCGGCGGTGCGCGGGG
CGTTGGGTCAGCGGGTCTGGGACTGGTGGCACCGGCGGCGGCGTAGGACGGAGGCGTTGCTAGG
CAGCTTCGAACCAGTGCAATGACGATGCCAGTCAACGGGGCCCACAAGGATGCTGAACTGTGGT
CCTCACATGACAAGATGCTGGCACAACCCCTCAAAGACAGTGATGTTGAGGTTTACAACATCAT
TAAGAAGGAGAGTAACCGGCAGAGGGTTGGATTGGAGCTGATTGCCTCGGAGAATTTCGCCAGC
CGAGCAGTTTTGGAGGCCCTAGGCTCTTGCTTAAATAACAAATACTCTGAGGGGTACCCGGGCC
AGAGATACTATGGCGGGACTGAGTTTATTGATGAACTGGAGACCCTCTGTCAGAAGCGAGCCCT
GCAGGCCTATAAGCTGGACCCACAGTGCTGGGGGGTCAACGTCCAGCCCTACTCAGGCTCCCCT
GCAAACTTCGCTGTGTACACTGCCCTGGTTGAACCCCATGGGCGCATCATGGGCCTGGACCTTC
CGGATGGGGGCCACCTGACCCATGGGTTCATGACAGACAAGAAGAAAATCTCTGCCACGTCCAT
CTTCTTTGAATCTATGCCCTACAAGGTGAACCCAGATACTGGCTACATCAACTATGACCAGCTG
GAGGAGAACGCACGCCTCTTCCACCCGAAGCTGATCATCGCAGGAACCAGCTGCTACTCCCGAA
ACCTGGAATATGCCCGGCTACGGAAGATTGCAGATGAGAACGGGGCGTATCTCATGGCGGACAT
GGCTCACATCAGCGGGCTGGTGGCGGCTGGCGTGGTGCCCTCCCCATTTGAACACTGCCATGTG
GTGACCACCACCACTCACAAGACCCTGCGAGGCTGCCGAGCTGGCATGATCTTCTACAGGAAAG
GAGTGAAAAGTGTGGATCCCAAGACTGGCAAAGAGATTCTGTACAACCTGGAGTCTCTTATCAA
TTCTGCTGTGTTCCCTGGCCTGCAGGGAGGTCCCCACAACCACACCATTGCTGGGGTTGCTGTG
GCACTGAAGCAAGCTATGACTCTGGAATTTAAAGTTTATCAACACCAGGTGGTGGCCAACTGCA
GGGCTCTGTCTGAGGCCCTGACGGAGCTGGGCTACAAAATAGTCACAGGTGGTTCTGACAACCA
TTTGATCCTTGTGGATCTCCGTTCCAAAGGCACAGATGGTGGAAGGGCTGAGAAGGTGCTAGAA
GCCTGTTCTATTGCCTGCAACAAGAACACCTGTCCAGGTGACAGAAGCGCTCTGCGGCCCAGTG
GACTGCGGCTGGGGACCCCAGCACTGACGTCCCGTGGACTTTTGGAAAAAGACTTCCAAAAAGT
AGCCCACTTTATTCACAGAGGGATAGAGCTGACCCTGCAGATCCAGAGCGACACTGGTGTCAGA
GCCACCCTGAAGGAGTTCAAGGAGAGACTGGCAGGGGATAAGTACCAGGCGGTTGTGCAGGCTC
TCCGGGAGGAGGTTGAGAGCTTCGCCTCTCTCTTCCCTCTGCCTGGCCTTCCTGACTTCTAAAG
GAGCGGGCCCACTCTGGACCCACCTGGCGCCACAGAGGAAGCTGCCTGCCGGAGGACCCCCACT
TGAGAGATGGATGAGCTGCTCCAAAGGGGAACTGTTGACACTCGGGCCCTTTGAGGGGGTTTCT
TTTGGACTTTTTTCATGTTTTCTTCACAAATCAAAATTTGTTTAAGTCTCATTGTTAGTAATTC
TGGGACAGGTTATTAAAGGATTTAAATTTGAACCTGGCTTTCTCACAGCTGGACATAATTCTAG
GAAAATAAAATACTATGTCGCCACTTGGCCATAATCATTTAGATGGTGGTGTAGGGCAAAGCTG
TTAGAAAGATTCTAGCGTTTTACTCTCCCTGGGCTTTCCTCCGCCTTGCTGCAACAGAGAGGAA
ATGCCCATGTCCACAGCTTGTACACACTGCCCCCTCACTATCTTGTTATCCAGTGGCATGCCAA
AGGAGAACTGAATTAGCTTCTGAAGCTTCTGCTGTAAATCAGAAGTGTATGTTAGTCAAGAGTA
AACAAGATGCACCCAGTATGGTGGGAGGGTTTTGCTGTCAGTAGCTCAAAGTATGGTATAGAAA
TGGCCTCCTCCCTCCATCCTGGGAAGTCCCAGTCCCATCCTGGTGTGAGAATCAACCAGGCTTT
CCTGCTCCACCTGAGATAACCAACTCCCTCCCGTAATCAGGAAGCCAAATGTCACCTTCCCAAA
GAAATTTTATTTTCACGTAGCTGAAGTGCAAAACATAGATGACCATTTTTAATAAGCACAATCA
AATTTTTAACCACAGAATGTCTACAAGAATTATAGCTTTAAAAAATACAACCAATTTTTATATT
TCAAAAATATTTGAACTCAAATAAATTAATTTCTTAAAAAGTA

hide sequence

RefSeq Acc Id:

XM_003809773 ⟹ XP_003809821

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	52,905,330 - 52,940,088 (+)	NCBI
NHGRI_mPanPan1	17	57,616,479 - 57,650,574 (+)	NCBI
Mhudiblu_PPA_v0	17	32,870,949 - 32,905,690 (-)	NCBI
PanPan1.1	17	37,849,206 - 37,884,220 (+)	NCBI

Sequence:

show sequence

CGGGGGCGGGGCCAAGCCCAAGCCTGGCGCGCAGGGTGCACCTACCGGAGCTCGAGCGGTCCAG
CGCCAAGTTCGGGGTTTGGGTTGGAGGGGCTGGTCACGTGGCTGGCCCGCGGCGGTGCGCGGGG
CGTTGGGTCAGCGGGTCTGGGACTGGTGGCACCGGCGGCGGCGTAGGACGGAGGCGTTGCTAGG
CAGCTTCGAACCAGTGCAATGACGATGCCAGTCAACGGGGCCCACAAGGATGCTGAACTGTGGT
CCTCACATGACAAGATGCTGGCACAACCCCTCAAAGACAGTGATGTTGAGGTTTACAACATCAT
TAAGAAGGAGAGTAACCGGCAGAGGGTTGGATTGGAGCTGATTGCCTCGGAGAATTTCGCCAGC
CGAGCAGTTTTGGAGGCCCTAGGCTCTTGCTTAAATAACAAATACTCTGAGGGGTACCCGGGCC
AGAGATACTATGGCGGGACTGAGTTTATTGATGAACTGGAGACCCTCTGTCAGAAGCGAGCCCT
GCAGGCCTATAAGCTGGACCCACAGTGCTGGGGGGTCAACGTCCAGCCCTACTCAGGCTCCCCT
GCAAACTTCGCTGTGTACACTGCCCTGGTTGAACCCCATGGGCGCATCATGGGCCTGGACCTTC
CGGATGGGGGCCACCTGACCCATGGGTTCATGACAGACAAGAAGAAAATCTCTGCCACGTCCAT
CTTCTTTGAATCTATGCCCTACAAGGTGAACCCAGATACTGGCTACATCAACTATGACCAGCTG
GAGGAGAACGCACGCCTCTTCCACCCGAAGCTGATCATCGCAGGAACCAGCTGCTACTCCCGAA
ACCTGGAATATGCCCGGCTACGGAAGATTGCAGATGAGAACGGGGCGTATCTCATGGCGGACAT
GGCTCACATCAGCGGGCTGGTGGCGGCTGGCGTGGTGCCCTCCCCATTTGAACACTGCCATGTG
GTGACCACCACCACTCACAAGACCCTGCGAGGCTGCCGAGCTGGCATGATCTTCTACAGGAAAG
GGGTTGCTGTGGCACTGAAGCAAGCTATGACTCTGGAATTTAAAGTTTATCAACACCAGGTGGT
GGCCAACTGCAGGGCTCTGTCTGAGGCCCTGACGGAGCTGGGCTACAAAATAGTCACAGGTGGT
TCTGACAACCATTTGATCCTTGTGGATCTCCGTTCCAAAGGCACAGATGGTGGAAGGGCTGAGA
AGGTGCTAGAAGCCTGTTCTATTGCCTGCAACAAGAACACCTGTCCAGGTGACAGAAGCGCTCT
GCGGCCCAGTGGACTGCGGCTGGGGACCCCAGCACTGACGTCCCGTGGACTTTTGGAAAAAGAC
TTCCAAAAAGTAGCCCACTTTATTCACAGAGGGATAGAGCTGACCCTGCAGATCCAGAGCGACA
CTGGTGTCAGAGCCACCCTGAAGGAGTTCAAGGAGAGACTGGCAGGGGATAAGTACCAGGCGGT
TGTGCAGGCTCTCCGGGAGGAGGTTGAGAGCTTCGCCTCTCTCTTCCCTCTGCCTGGCCTTCCT
GACTTCTAAAGGAGCGGGCCCACTCTGGACCCACCTGGCGCCACAGAGGAAGCTGCCTGCCGGA
GGACCCCCACTTGAGAGATGGATGAGCTGCTCCAAAGGGGAACTGTTGACACTCGGGCCCTTTG
AGGGGGTTTCTTTTGGACTTTTTTCATGTTTTCTTCACAAATCAAAATTTGTTTAAGTCTCATT
GTTAGTAATTCTGGGACAGGTTATTAAAGGATTTAAATTTGAACCTGGCTTTCTCACAGCTGGA
CATAATTCTAGGAAAATAAAATACTATGTCGCCACTTGGCCATAATCATTTAGATGGTGGTGTA
GGGCAAAGCTGTTAGAAAGATTCTAGCGTTTTACTCTCCCTGGGCTTTCCTCCGCCTTGCTGCA
ACAGAGAGGAAATGCCCATGTCCACAGCTTGTACACACTGCCCCCTCACTATCTTGTTATCCAG
TGGCATGCCAAAGGAGAACTGAATTAGCTTCTGAAGCTTCTGCTGTAAATCAGAAGTGTATGTT
AGTCAAGAGTAAACAAGATGCACCCAGTATGGTGGGAGGGTTTTGCTGTCAGTAGCTCAAAGTA
TGGTATAGAAATGGCCTCCTCCCTCCATCCTGGGAAGTCCCAGTCCCATCCTGGTGTGAGAATC
AACCAGGCTTTCCTGCTCCACCTGAGATAACCAACTCCCTCCCGTAATCAGGAAGCCAAATGTC
ACCTTCCCAAAGAAATTTTATTTTCACGTAGCTGAAGTGCAAAACATAGATGACCATTTTTAAT
AAGCACAATCAAATTTTTAACCACAGAATGTCTACAAGAATTATAGCTTTAAAAAATACAACCA
ATTTTTATATTTCAAAAATATTTGAACTCAAATAAATTAATTTCTTAAAAAGTA

hide sequence

RefSeq Acc Id:

XM_008962069 ⟹ XP_008960317

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	52,905,370 - 52,940,088 (+)	NCBI
NHGRI_mPanPan1	17	57,616,521 - 57,650,574 (+)	NCBI
Mhudiblu_PPA_v0	17	32,871,595 - 32,905,660 (-)	NCBI
PanPan1.1	17	37,849,213 - 37,884,220 (+)	NCBI

Sequence:

show sequence

GGGGCCAAGCCCAAGCCTGGCGCGCAGGGTGCACCTACCGGAGCTCGAGCGGTCCAGCGCCAAG
TTCGGGGTTTGGGTTGGAGGGGCTGGTCACGTGGCTGGCCCGCGGCGGTGCGCGGGGCGTTGGG
TCAGCGGGTCTGGGACTGGTGGCACCGGCGGCGGCGTAGGACGGAGGCGTTGCTAGGCAGCTTC
GAACCAGTGCAATGACGATGCCAGTCAACGGGGCCCACAAGGATGCTGAACTGTGGTCCTCACA
TGACAAGATGCTGGCACAACCCCTCAAAGACAGTGATGTTGAGGTTTACAACATCATTAAGAAG
GAGAGTAACCGGCAGAGGGTTGGATTGGAGCTGATTGCCTCGGAGAATTTCGCCAGCCGAGCAG
TTTTGGAGGCCCTAGGCTCTTGCTTAAATAACAAATACTCTGAGGGGTACCCGGGCCAGAGATA
CTATGGCGGGACTGAGTTTATTGATGAACTGGAGACCCTCTGTCAGAAGCGAGCCCTGCAGGCC
TATAAGCTGGACCCACAGTGCTGGGGGGTCAACGTCCAGCCCTACTCAGGCTCCCCTGCAAACT
TCGCTGTGTACACTGCCCTGGTTGAACCCCATGGGCGCATCATGGGCCTGGACCTTCCGGATGG
GGGCCACCTGACCCATGGGTTCATGACAGACAAGAAGAAAATCTCTGCCACGTCCATCTTCTTT
GAATCTATGCCCTACAAGGTGAACCCAGATACTGGCTACATCAACTATGACCAGCTGGAGGAGA
ACGCACGCCTCTTCCACCCGAAGCTGATCATCGCAGGAACCAGCTGCTACTCCCGAAACCTGGA
ATATGCCCGGCTACGGAAGATTGCAGATGAGAACGGGGCGTATCTCATGGCGGACATGGCTCAC
ATCAGCGGGCTGGTGGCGGCTGGCGTGGTGCCCTCCCCATTTGAACACTGCCATGTGGTGACCA
CCACCACTCACAAGACCCTGCGAGGCTGCCGAGCTGGCATGATCTTCTACAGGAAAGGTGGTTC
TGACAACCATTTGATCCTTGTGGATCTCCGTTCCAAAGGCACAGATGGTGGAAGGGCTGAGAAG
GTGCTAGAAGCCTGTTCTATTGCCTGCAACAAGAACACCTGTCCAGGTGACAGAAGCGCTCTGC
GGCCCAGTGGACTGCGGCTGGGGACCCCAGCACTGACGTCCCGTGGACTTTTGGAAAAAGACTT
CCAAAAAGTAGCCCACTTTATTCACAGAGGGATAGAGCTGACCCTGCAGATCCAGAGCGACACT
GGTGTCAGAGCCACCCTGAAGGAGTTCAAGGAGAGACTGGCAGGGGATAAGTACCAGGCGGTTG
TGCAGGCTCTCCGGGAGGAGGTTGAGAGCTTCGCCTCTCTCTTCCCTCTGCCTGGCCTTCCTGA
CTTCTAAAGGAGCGGGCCCACTCTGGACCCACCTGGCGCCACAGAGGAAGCTGCCTGCCGGAGG
ACCCCCACTTGAGAGATGGATGAGCTGCTCCAAAGGGGAACTGTTGACACTCGGGCCCTTTGAG
GGGGTTTCTTTTGGACTTTTTTCATGTTTTCTTCACAAATCAAAATTTGTTTAAGTCTCATTGT
TAGTAATTCTGGGACAGGTTATTAAAGGATTTAAATTTGAACCTGGCTTTCTCACAGCTGGACA
TAATTCTAGGAAAATAAAATACTATGTCGCCACTTGGCCATAATCATTTAGATGGTGGTGTAGG
GCAAAGCTGTTAGAAAGATTCTAGCGTTTTACTCTCCCTGGGCTTTCCTCCGCCTTGCTGCAAC
AGAGAGGAAATGCCCATGTCCACAGCTTGTACACACTGCCCCCTCACTATCTTGTTATCCAGTG
GCATGCCAAAGGAGAACTGAATTAGCTTCTGAAGCTTCTGCTGTAAATCAGAAGTGTATGTTAG
TCAAGAGTAAACAAGATGCACCCAGTATGGTGGGAGGGTTTTGCTGTCAGTAGCTCAAAGTATG
GTATAGAAATGGCCTCCTCCCTCCATCCTGGGAAGTCCCAGTCCCATCCTGGTGTGAGAATCAA
CCAGGCTTTCCTGCTCCACCTGAGATAACCAACTCCCTCCCGTAATCAGGAAGCCAAATGTCAC
CTTCCCAAAGAAATTTTATTTTCACGTAGCTGAAGTGCAAAACATAGATGACCATTTTTAATAA
GCACAATCAAATTTTTAACCACAGAATGTCTACAAGAATTATAGCTTTAAAAAATACAACCAAT
TTTTATATTTCAAAAATATTTGAACTCAAATAAATTAATTTCTTAAAAAGTA

hide sequence

RefSeq Acc Id:

XM_034942295 ⟹ XP_034798186

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	52,905,371 - 52,940,088 (+)	NCBI
NHGRI_mPanPan1	17	57,616,522 - 57,650,574 (+)	NCBI
Mhudiblu_PPA_v0	17	32,871,595 - 32,905,669 (-)	NCBI

RefSeq Acc Id:

XM_055101796 ⟹ XP_054957771

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	52,905,551 - 52,940,088 (+)	NCBI
NHGRI_mPanPan1	17	57,616,700 - 57,650,574 (+)	NCBI

RefSeq Acc Id:

XM_055101797 ⟹ XP_054957772

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	52,905,537 - 52,940,088 (+)	NCBI
NHGRI_mPanPan1	17	57,616,686 - 57,650,574 (+)	NCBI

RefSeq Acc Id:

XM_055101798 ⟹ XP_054957773

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	52,905,369 - 52,940,088 (+)	NCBI
NHGRI_mPanPan1	17	57,616,521 - 57,650,574 (+)	NCBI

RefSeq Acc Id:

XM_055101799 ⟹ XP_054957774

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	52,905,546 - 52,940,088 (+)	NCBI
NHGRI_mPanPan1	17	57,616,695 - 57,650,574 (+)	NCBI

RefSeq Acc Id:

XM_055101800 ⟹ XP_054957775

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	52,905,553 - 52,940,088 (+)	NCBI
NHGRI_mPanPan1	17	57,616,702 - 57,650,574 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003809820	(Get FASTA)	NCBI Sequence Viewer
	XP_003809821	(Get FASTA)	NCBI Sequence Viewer
	XP_008960317	(Get FASTA)	NCBI Sequence Viewer
	XP_034798186	(Get FASTA)	NCBI Sequence Viewer
	XP_054957771	(Get FASTA)	NCBI Sequence Viewer
	XP_054957772	(Get FASTA)	NCBI Sequence Viewer
	XP_054957773	(Get FASTA)	NCBI Sequence Viewer
	XP_054957774	(Get FASTA)	NCBI Sequence Viewer
	XP_054957775	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000013608
	ENSPPAP00000013608.1
	ENSPPAP00000013611
	ENSPPAP00000013611.1

RefSeq Acc Id:	XP_003809820 ⟸ XM_003809772
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9ADM5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTMPVNGAHKDAELWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEA LGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVY TALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARL FHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTH KTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHTIAGVAVALKQAM TLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIAC NKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEF KERLAGDKYQAVVQALREEVESFASLFPLPGLPDF hide sequence

RefSeq Acc Id:	XP_003809821 ⟸ XM_003809773
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9A9P3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTMPVNGAHKDAELWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEA LGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVY TALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARL FHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTH KTLRGCRAGMIFYRKGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLI LVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAH FIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAVVQALREEVESFASLFPLPGLPDF hide sequence

RefSeq Acc Id:

XP_008960317 ⟸ XM_008962069

- Peptide Label:

isoform X3

- Sequence:

show sequence

MTMPVNGAHKDAELWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEA
LGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVY
TALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARL
FHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTH
KTLRGCRAGMIFYRKGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSG
LRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAVVQAL
REEVESFASLFPLPGLPDF

hide sequence

RefSeq Acc Id:	XP_034798186 ⟸ XM_034942295
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9ADM5 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSPPAP00000013611 ⟸ ENSPPAT00000036284

RefSeq Acc Id:

ENSPPAP00000013608 ⟸ ENSPPAT00000036281

RefSeq Acc Id:	XP_054957773 ⟸ XM_055101798
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9A9P3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054957772 ⟸ XM_055101797
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9ADM5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054957774 ⟸ XM_055101799
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9A9P3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054957771 ⟸ XM_055101796
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9ADM5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054957775 ⟸ XM_055101800
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9A9P3 (UniProtKB/TrEMBL)

Protein Domains

Serine hydroxymethyltransferase-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000029976	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000036281.1	UniProtKB/TrEMBL
	ENSPPAT00000036284.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.640.10	UniProtKB/TrEMBL
	3.90.1150.10	UniProtKB/TrEMBL
InterPro	PyrdxlP-dep_Trfase	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_major	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_small	UniProtKB/TrEMBL
	Ser_HO-MeTrfase	UniProtKB/TrEMBL
	Ser_HO-MeTrfase_PLP_BS	UniProtKB/TrEMBL
	SHMT-like_dom	UniProtKB/TrEMBL
KEGG Report	pps:100969107	UniProtKB/TrEMBL
NCBI Gene	SHMT1	ENTREZGENE
PANTHER	PTHR11680	UniProtKB/TrEMBL
	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC	UniProtKB/TrEMBL
Pfam	SHMT	UniProtKB/TrEMBL
PIRSF	SHMT	UniProtKB/TrEMBL
PROSITE	SHMT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53383	UniProtKB/TrEMBL
UniProt	A0A2R9A9P3	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9ADM5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB