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Gene: SHMT1 (serine hydroxymethyltransferase 1) Homo sapiens
Symbol: SHMT1
Name: serine hydroxymethyltransferase 1
RGD ID: 1323770
Description: Exhibits several functions, including anion binding activity; glycine hydroxymethyltransferase activity; and nucleic acid binding activity. Involved in several processes, including carboxylic acid metabolic process; cellular response to tetrahydrofolate; and protein homotetramerization. Localizes to cytosol and nucleoplasm. Implicated in breast cancer. Biomarker of ovarian cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 14 kDa protein; CSHMT; cytoplasmic serine hydroxymethyltransferase; glycine hydroxymethyltransferase; MGC15229; MGC24556; serine hydroxymethyltransferase 1 (soluble); serine hydroxymethyltransferase, cytosolic; serine methylase; SHMT
Mus musculus (house mouse) : Shmt1 (serine hydroxymethyltransferase 1 (soluble))  MGI  Alliance
Rattus norvegicus (Norway rat) : Shmt1 (serine hydroxymethyltransferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shmt1 (serine hydroxymethyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SHMT1 (serine hydroxymethyltransferase 1)
Canis lupus familiaris (dog) : SHMT1 (serine hydroxymethyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shmt1 (serine hydroxymethyltransferase 1)
Sus scrofa (pig) : SHMT1 (serine hydroxymethyltransferase 1)
Chlorocebus sabaeus (African green monkey) : SHMT1 (serine hydroxymethyltransferase 1)
Heterocephalus glaber (naked mole-rat) : Shmt1 (serine hydroxymethyltransferase 1)
more info ...
Related Pseudogenes: SHMT1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1718,327,860 - 18,363,563 (-)EnsemblGRCh38hg38GRCh38
GRCh381718,327,873 - 18,363,560 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371718,231,187 - 18,266,856 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,171,912 - 18,207,581 (-)NCBINCBI36hg18NCBI36
Build 341718,171,912 - 18,207,581NCBI
Celera1719,172,258 - 19,207,893 (-)NCBI
Cytogenetic Map17p11.2NCBI
HuRef1717,984,719 - 18,020,240 (-)NCBIHuRef
CHM1_11718,239,933 - 18,275,860 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SHMT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323770
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.