| 1304729 | Sfn | stratifin | ENCODES a protein that exhibits identical protein binding (ortholog); phosphoprotein binding (ortholog); phosphoserine residue binding (ortholog); INVOLVED IN cAMP/PKA signal transduction (ortholog); establishment of skin barrier (ortholog); intrinsic apoptotic signaling pathway in response to DNA d amage (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH endometrial carcinoma (ortholog); Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2-acetamidofluorene; 5-aza-2'-deoxycytidine | 5 | 151110582 | 151111854 | Rat | 323 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1312341 | SFN | stratifin | This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017] | 1 | 26863149 | 26864456 | Human | 367 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1312342 | Sfn | stratifin | Enables phosphoprotein binding activity and protein kinase binding activity. Involved in several processes, including cAMP/PKA signal transduction; establishment of skin barrier; and protein export from nucleus. Acts upstream of or within several processes, including keratinocyte differentiation; ne gative regulation of cell population proliferation; and regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to human SFN (stratifin). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 133327867 | 133329163 | Mouse | 471 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8724293 | Sfn | stratifin | ENCODES a protein that exhibits identical protein binding (ortholog); phosphoprotein binding (ortholog); phosphoserine residue binding (ortholog); INVOLVED IN cAMP/PKA signal transduction (ortholog); establishment of skin barrier (ortholog); intrinsic apoptotic signaling pathway in response to DNA d amage (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH endometrial carcinoma (ortholog); Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog) | NW_004955452 | 6217519 | 6218481 | Chinchilla | 101 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12049043 | SFN | stratifin | ENCODES a protein that exhibits identical protein binding (inferred); phosphoprotein binding (inferred); phosphoserine residue binding (inferred); INVOLVED IN keratinization (ortholog); keratinocyte development (ortholog); keratinocyte differentiation (ortholog); PARTICIPATES IN insulin responsive f acilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH endometrial carcinoma (ortholog); Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytosol (ortholog) | 1 | 26126212 | 26127761 | Bonobo | 100 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12074273 | SFN | stratifin | ENCODES a protein that exhibits identical protein binding (ortholog); phosphoprotein binding (ortholog); phosphoserine residue binding (ortholog); INVOLVED IN cAMP/PKA signal transduction (ortholog); establishment of skin barrier (ortholog); intrinsic apoptotic signaling pathway in response to DNA d amage (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH endometrial carcinoma (ortholog); Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog) | 2 | 73268289 | 73269663 | Dog | 101 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12587384 | Sfn | stratifin | ENCODES a protein that exhibits identical protein binding (inferred); phosphoprotein binding (inferred); phosphoserine residue binding (inferred); INVOLVED IN keratinization (ortholog); keratinocyte development (ortholog); keratinocyte differentiation (ortholog); PARTICIPATES IN insulin responsive f acilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH endometrial carcinoma (ortholog); Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytosol (ortholog) | NW_004936474 | 11274927 | 11279427 | Squirrel | 99 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18926488 | Sfn | stratifin | ENCODES a protein that exhibits identical protein binding (inferred); phosphoprotein binding (inferred); phosphoserine residue binding (inferred); INVOLVED IN keratinization (ortholog); keratinocyte development (ortholog); keratinocyte differentiation (ortholog); PARTICIPATES IN insulin responsive f acilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH endometrial carcinoma (ortholog); Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 99 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13931810 | SFN | stratifin | ENCODES a protein that exhibits identical protein binding (inferred); phosphoprotein binding (inferred); phosphoserine residue binding (inferred); INVOLVED IN keratinization (ortholog); keratinocyte development (ortholog); keratinocyte differentiation (ortholog); PARTICIPATES IN insulin responsive f acilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH endometrial carcinoma (ortholog); Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytosol (ortholog) | | | | Pig | 103 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626103406 | Sfn | stratifin | ENCODES a protein that exhibits identical protein binding (ortholog); phosphoprotein binding (ortholog); phosphoserine residue binding (ortholog); INVOLVED IN cAMP/PKA signal transduction (ortholog); establishment of skin barrier (ortholog); intrinsic apoptotic signaling pathway in response to DNA d amage (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH endometrial carcinoma (ortholog); Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog) | | | | Black Rat | 101 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18756265 | SFN | stratifin | ENCODES a protein that exhibits identical protein binding (inferred); phosphoprotein binding (inferred); phosphoserine residue binding (inferred); INVOLVED IN keratinization (ortholog); keratinocyte development (ortholog); keratinocyte differentiation (ortholog); PARTICIPATES IN insulin responsive f acilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH endometrial carcinoma (ortholog); Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytosol (ortholog) | | | | Green Monkey | 100 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1583672 | Sfn-ps1 | stratifin, pseudogene 1 | | 13 | 105553620 | 105555487 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1603665 | REXO2 | RNA exonuclease 2 | This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of h uman cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011] | 11 | 114439467 | 114450279 | Human | 126 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1620676 | Rexo2 | RNA exonuclease 2 | Predicted to enable 3'-5'-DNA exonuclease activity; 3'-5'-RNA exonuclease activity; and magnesium ion binding activity. Predicted to be involved in DNA metabolic process. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Located in mitochondrion. Is expressed i n several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human REXO2 (RNA exonuclease 2). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 48379812 | 48391911 | Mouse | 154 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1359510 | Sfnl1 | stratifin like 1 | FOUND IN cytoplasm (inferred); INTERACTS WITH triticonazole | 6 | 28716918 | 28718201 | Rat | 6 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 737151 | SCN9A | sodium voltage-gated channel alpha subunit 9 | This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009] | 2 | 166195185 | 166375987 | Human | 470 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |