| 3660 | Selenop | selenoprotein P | ENCODES a protein that exhibits selenium binding (ortholog); INVOLVED IN response to selenium ion; brain development (ortholog); locomotory behavior (ortholog); ASSOCIATED WITH adenoma (ortholog); Animal Mammary Neoplasms (ortholog); Cadmium Poisoning (ortholog); FOUND IN extracellular space (orthol og); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol | 2 | 54225736 | 54236022 | Rat | 307 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 737591 | SELENOP | selenoprotein P | This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018] | 5 | 42799880 | 42811892 | Human | 317 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 737592 | Selenop | selenoprotein P | This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in mouse), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants differing in 5' non-coding region have been described for this gene. Expression of these variants varies in different tissues and developmental stages (PMID:23064117). [provided by RefSeq, Feb 2017] | 15 | 3300249 | 3309992 | Mouse | 357 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8855019 | Selenop | selenoprotein P | ENCODES a protein that exhibits selenium binding (ortholog); INVOLVED IN brain development (ortholog); locomotory behavior (ortholog); post-embryonic development (ortholog); ASSOCIATED WITH adenoma (ortholog); Animal Mammary Neoplasms (ortholog); Cadmium Poisoning (ortholog); FOUND IN extracellular space (ortholog) | NW_004955426 | 26951003 | 26961839 | Chinchilla | 33 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11857290 | SELENOP | selenoprotein P | ENCODES a protein that exhibits selenium binding (inferred); INVOLVED IN brain development (ortholog); locomotory behavior (ortholog); post-embryonic development (ortholog); ASSOCIATED WITH adenoma (ortholog); Animal Mammary Neoplasms (ortholog); Cadmium Poisoning (ortholog); FOUND IN extracellular space (ortholog) | 5 | 67570087 | 67582192 | Bonobo | 37 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12204302 | SELENOP | selenoprotein P | ENCODES a protein that exhibits selenium binding (inferred); INVOLVED IN brain development (ortholog); locomotory behavior (ortholog); post-embryonic development (ortholog); ASSOCIATED WITH adenoma (ortholog); Animal Mammary Neoplasms (ortholog); Cadmium Poisoning (ortholog); FOUND IN extracellular space (ortholog) | 4 | 66953060 | 66964162 | Dog | 35 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12663266 | Selenop | selenoprotein P | ENCODES a protein that exhibits selenium binding (inferred); INVOLVED IN brain development (ortholog); locomotory behavior (ortholog); post-embryonic development (ortholog); ASSOCIATED WITH adenoma (ortholog); Animal Mammary Neoplasms (ortholog); Cadmium Poisoning (ortholog); FOUND IN extracellular space (ortholog) | NW_004936518 | 155905 | 166932 | Squirrel | 37 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18923264 | Selenop | selenoprotein P | ENCODES a protein that exhibits selenium binding (inferred); INVOLVED IN brain development (ortholog); locomotory behavior (ortholog); post-embryonic development (ortholog); ASSOCIATED WITH adenoma (ortholog); Animal Mammary Neoplasms (ortholog); Cadmium Poisoning (ortholog); FOUND IN extracellular space (ortholog) | | | | Naked Mole-Rat | 37 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18490934 | SELENOP | selenoprotein P | ENCODES a protein that exhibits selenium binding (ortholog); INVOLVED IN brain development (ortholog); locomotory behavior (ortholog); post-embryonic development (ortholog); ASSOCIATED WITH adenoma (ortholog); Animal Mammary Neoplasms (ortholog); Cadmium Poisoning (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 33 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 13844646 | SELENOP | selenoprotein P | ENCODES a protein that exhibits selenium binding (inferred); INVOLVED IN brain development (ortholog); locomotory behavior (ortholog); post-embryonic development (ortholog); ASSOCIATED WITH adenoma (ortholog); Animal Mammary Neoplasms (ortholog); Cadmium Poisoning (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 35 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16566310 | AC008945.1 | novel transcript, antisense to SEPP1 | | | | | Human | | name | gene, lncrna |
| 16571392 | AC008945.2 | novel transcript, antisense to SEPP1 | | | | | Human | | name | gene, lncrna |
