| 3631 | Scn1b | sodium voltage-gated channel beta subunit 1 | ENCODES a protein that exhibits sodium channel regulator activity; sodium channel inhibitor activity (ortholog); INVOLVED IN regulation of sodium ion transport; regulation of voltage-gated sodium channel activity; response to pyrethroid; PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacai ne pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH type 2 diabetes mellitus; asphyxiating thoracic dystrophy 3 (ortholog); benign epilepsy with centrotemporal spikes (ortholog); FOUND IN node of Ranvier; plasma membrane; voltage-gated sodium channel complex; INTERACTS WITH (+)-trans-(S)-allethrin; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether | 1 | 95481298 | 95491211 | Rat | 253 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 737154 | Scn1b | sodium channel, voltage-gated, type I, beta | Enables sodium channel inhibitor activity. Involved in several processes, including membrane depolarization during cardiac muscle cell action potential; regulation of sodium ion transport; and regulation of ventricular cardiac muscle cell membrane repolarization. Acts upstream of or within several p rocesses, including corticospinal neuron axon guidance; neuronal action potential propagation; and positive regulation of neuron projection development. Located in T-tubule; intercalated disc; and node of Ranvier. Part of voltage-gated sodium channel complex. Is expressed in heart and telencephalon. Used to study generalized epilepsy with febrile seizures plus. Human ortholog(s) of this gene implicated in Brugada syndrome 5; developmental and epileptic encephalopathy 52; familial atrial fibrillation; and generalized epilepsy with febrile seizures plus 1. Orthologous to human SCN1B (sodium voltage-gated channel beta subunit 1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 30815949 | 30826436 | Mouse | 266 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1350483 | SCN1B | sodium voltage-gated channel beta subunit 1 | Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinet ics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] | 19 | 35030470 | 35040449 | Human | 522 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8705090 | Scn1b | sodium voltage-gated channel beta subunit 1 | ENCODES a protein that exhibits sodium channel inhibitor activity (ortholog); sodium channel regulator activity (ortholog); INVOLVED IN axon guidance (ortholog); cardiac conduction (ortholog); cardiac muscle cell action potential involved in contraction (ortholog); PARTICIPATES IN alfentanil pharmac odynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH asphyxiating thoracic dystrophy 3 (ortholog); benign epilepsy with centrotemporal spikes (ortholog); Brugada syndrome (ortholog); FOUND IN intercalated disc (ortholog); node of Ranvier (ortholog); plasma membrane (ortholog) | NW_004955468 | 4375517 | 4383383 | Chinchilla | 118 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12037991 | SCN1B | sodium voltage-gated channel beta subunit 1 | ENCODES a protein that exhibits sodium channel regulator activity (ortholog); INVOLVED IN axon guidance (ortholog); corticospinal neuron axon guidance (ortholog); locomotion (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacod ynamics pathway; ASSOCIATED WITH asphyxiating thoracic dystrophy 3 (ortholog); benign epilepsy with centrotemporal spikes (ortholog); Brugada syndrome (ortholog); FOUND IN plasma membrane (ortholog); voltage-gated sodium channel complex (ortholog) | 19 | 31974499 | 31984488 | Bonobo | 127 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12317220 | SCN1B | sodium voltage-gated channel beta subunit 1 | ENCODES a protein that exhibits sodium channel regulator activity (ortholog); INVOLVED IN axon guidance (ortholog); corticospinal neuron axon guidance (ortholog); locomotion (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacod ynamics pathway; ASSOCIATED WITH asphyxiating thoracic dystrophy 3 (ortholog); benign epilepsy with centrotemporal spikes (ortholog); Brugada syndrome (ortholog); FOUND IN plasma membrane (ortholog); voltage-gated sodium channel complex (ortholog) | 1 | 117504428 | 117510666 | Dog | 126 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12523474 | Scn1b | sodium voltage-gated channel beta subunit 1 | ENCODES a protein that exhibits sodium channel regulator activity (ortholog); INVOLVED IN axon guidance (ortholog); corticospinal neuron axon guidance (ortholog); locomotion (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacod ynamics pathway; ASSOCIATED WITH asphyxiating thoracic dystrophy 3 (ortholog); benign epilepsy with centrotemporal spikes (ortholog); Brugada syndrome (ortholog); FOUND IN plasma membrane (ortholog); voltage-gated sodium channel complex (ortholog) | NW_004936570 | 1187916 | 1195423 | Squirrel | 127 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14070481 | SCN1B | sodium voltage-gated channel beta subunit 1 | ENCODES a protein that exhibits sodium channel regulator activity (ortholog); INVOLVED IN axon guidance (ortholog); corticospinal neuron axon guidance (ortholog); locomotion (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacod ynamics pathway; ASSOCIATED WITH asphyxiating thoracic dystrophy 3 (ortholog); benign epilepsy with centrotemporal spikes (ortholog); Brugada syndrome (ortholog); FOUND IN plasma membrane (ortholog); voltage-gated sodium channel complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 131 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18925010 | Scn1b | sodium voltage-gated channel beta subunit 1 | ENCODES a protein that exhibits sodium channel regulator activity (ortholog); INVOLVED IN axon guidance (ortholog); cardiac conduction (ortholog); cardiac muscle contraction (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacod ynamics pathway; ASSOCIATED WITH asphyxiating thoracic dystrophy 3 (ortholog); benign epilepsy with centrotemporal spikes (ortholog); Brugada syndrome (ortholog); FOUND IN intercalated disc (ortholog); node of Ranvier (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 123 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18737429 | SCN1B | sodium voltage-gated channel beta subunit 1 | ENCODES a protein that exhibits sodium channel regulator activity (ortholog); INVOLVED IN axon guidance (ortholog); corticospinal neuron axon guidance (ortholog); locomotion (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacod ynamics pathway; ASSOCIATED WITH asphyxiating thoracic dystrophy 3 (ortholog); benign epilepsy with centrotemporal spikes (ortholog); Brugada syndrome (ortholog); FOUND IN plasma membrane (ortholog); voltage-gated sodium channel complex (ortholog) | | | | Green Monkey | 127 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626063604 | Scn1b | sodium voltage-gated channel beta subunit 1 | ENCODES a protein that exhibits sodium channel inhibitor activity (ortholog); sodium channel regulator activity (ortholog); INVOLVED IN axon guidance (ortholog); cardiac conduction (ortholog); cardiac muscle cell action potential involved in contraction (ortholog); PARTICIPATES IN alfentanil pharmac odynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH asphyxiating thoracic dystrophy 3 (ortholog); benign epilepsy with centrotemporal spikes (ortholog); Brugada syndrome (ortholog); FOUND IN intercalated disc (ortholog); node of Ranvier (ortholog); plasma membrane (ortholog) | | | | Black Rat | 114 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288083488 | scn1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 287335844 | scn1b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284146814 | scn1b.S | | | | | | African Clawed Frog | | symbol | gene, null |
