| 68952 | Ryr3 | ryanodine receptor 3 | ENCODES a protein that exhibits calcium-induced calcium release activity; ryanodine-sensitive calcium-release channel activity; intracellularly gated calcium channel activity (ortholog); INVOLVED IN negative regulation of cytosolic calcium ion concentration; response to hypoxia; calcium ion transpor t (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; Alzheimer's disease pathway; ASSOCIATED WITH pulmonary hypertension; colorectal cancer (ortholog); congenital myopathy 20 (ortholog); FOUND IN cytoplasmic side of plasma membrane; perinuclear region of cytoplasm; junctional membrane complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide | 3 | 119886129 | 120433465 | Rat | 139 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 69015 | RYR3 | ryanodine receptor 3 | The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by dep olarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] | 15 | 33310967 | 33866102 | Human | 1477 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 69016 | Ryr3 | ryanodine receptor 3 | Enables ryanodine-sensitive calcium-release channel activity. Acts upstream of or within intracellular calcium ion homeostasis and striated muscle contraction. Located in sarcoplasmic reticulum membrane. Part of junctional membrane complex. Is expressed in several structures, including cardiovascula r system; central nervous system; diaphragm; hemolymphoid system; and musculature. Human ortholog(s) of this gene implicated in congenital myopathy 20 and hepatocellular carcinoma. Orthologous to human RYR3 (ryanodine receptor 3). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 112461699 | 113047755 | Mouse | 167 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8995179 | Ryr3 | ryanodine receptor 3 | ENCODES a protein that exhibits calcium-induced calcium release activity (ortholog); intracellularly gated calcium channel activity (ortholog); ryanodine-sensitive calcium-release channel activity (ortholog); INVOLVED IN calcium ion transport (ortholog); intracellular calcium ion homeostasis (orthol og); negative regulation of cytosolic calcium ion concentration (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); congenital myopathy 20 (ortholog); Contracture (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); junctional membrane complex (ortholog); perinuclear region of cytoplasm (ortholog) | NW_004955416 | 712506 | 1260111 | Chinchilla | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11964246 | RYR3 | ryanodine receptor 3 | ENCODES a protein that exhibits calcium-induced calcium release activity (ortholog); ryanodine-sensitive calcium-release channel activity (ortholog); INVOLVED IN intracellular calcium ion homeostasis (ortholog); negative regulation of cytosolic calcium ion concentration (ortholog); response to hypox ia (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); congenital myopathy 20 (ortholog); Contracture (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); junctional membrane complex (ortholog); perinuclear region of cytoplasm (ortholog) | 15 | 11816430 | 12379101 | Bonobo | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12219187 | RYR3 | ryanodine receptor 3 | ENCODES a protein that exhibits calcium-induced calcium release activity (ortholog); ryanodine-sensitive calcium-release channel activity (ortholog); INVOLVED IN intracellular calcium ion homeostasis (ortholog); negative regulation of cytosolic calcium ion concentration (ortholog); response to hypox ia (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); congenital myopathy 20 (ortholog); Contracture (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); junctional membrane complex (ortholog); perinuclear region of cytoplasm (ortholog) | 30 | 1179575 | 1533352 | Dog | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12501006 | Ryr3 | ryanodine receptor 3 | ENCODES a protein that exhibits calcium-induced calcium release activity (ortholog); ryanodine-sensitive calcium-release channel activity (ortholog); INVOLVED IN intracellular calcium ion homeostasis (ortholog); negative regulation of cytosolic calcium ion concentration (ortholog); response to hypox ia (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); congenital myopathy 20 (ortholog); Contracture (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); junctional membrane complex (ortholog); perinuclear region of cytoplasm (ortholog) | NW_004936673 | 2078095 | 2434872 | Squirrel | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13906535 | RYR3 | ryanodine receptor 3 | ENCODES a protein that exhibits calcium-induced calcium release activity (ortholog); ryanodine-sensitive calcium-release channel activity (ortholog); INVOLVED IN intracellular calcium ion homeostasis (ortholog); negative regulation of cytosolic calcium ion concentration (ortholog); response to hypox ia (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); congenital myopathy 20 (ortholog); Contracture (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); junctional membrane complex (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Pig | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866303 | RYR3 | ryanodine receptor 3 | ENCODES a protein that exhibits calcium channel activity (inferred); calcium ion binding (inferred); calmodulin binding (inferred); INVOLVED IN calcium ion transmembrane transport (inferred); calcium ion transport (inferred); calcium-mediated signaling (inferred); FOUND IN calcium channel complex (i nferred); membrane (inferred); sarcolemma (inferred) | | | | Green Monkey | 28 | symbol | gene, protein-coding |
| 284085230 | ryr3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626091166 | Ryr3 | ryanodine receptor 3 | ENCODES a protein that exhibits calcium-induced calcium release activity (ortholog); intracellularly gated calcium channel activity (ortholog); ryanodine-sensitive calcium-release channel activity (ortholog); INVOLVED IN calcium ion transport (ortholog); intracellular calcium ion homeostasis (orthol og); negative regulation of cytosolic calcium ion concentration (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); congenital myopathy 20 (ortholog); Contracture (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); junctional membrane complex (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Black Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935342 | Ryr3 | ryanodine receptor 3 | ENCODES a protein that exhibits calcium-induced calcium release activity (ortholog); intracellularly gated calcium channel activity (ortholog); ryanodine-sensitive calcium-release channel activity (ortholog); INVOLVED IN intracellular calcium ion homeostasis (ortholog); negative regulation of cytoso lic calcium ion concentration (ortholog); response to hypoxia (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); congenital myopathy 20 (ortholog); Contracture (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); junctional membrane complex (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Naked Mole-Rat | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18460820 | RYR3 | ryanodine receptor 3 | ENCODES a protein that exhibits calcium-induced calcium release activity (ortholog); intracellularly gated calcium channel activity (ortholog); ryanodine-sensitive calcium-release channel activity (ortholog); INVOLVED IN calcium ion transport (ortholog); intracellular calcium ion homeostasis (orthol og); negative regulation of cytosolic calcium ion concentration (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); congenital myopathy 20 (ortholog); Contracture (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); junctional membrane complex (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288057104 | ryr3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284085556 | ryr3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16562218 | RYR3-DT | RYR3 divergent transcript | INTERACTS WITH aristolochic acid A | 15 | 33303657 | 33310659 | Human | 1 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 616940384 | RYR3-AS1 | RYR3 antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 16562124 | AC010809.1 | novel transcript, antisense to RYR3 | | | | | Human | | name | gene, lncrna |
| 16562197 | AC010809.2 | novel transcript, antisense to RYR3 | | | | | Human | | name | gene, lncrna |
| 16567968 | AC010809.3 | novel transcript, antisense to RYR3 | | | | | Human | | name | gene, lncrna |
