| 1305275 | Ror2 | receptor tyrosine kinase-like orphan receptor 2 | ENCODES a protein that exhibits frizzled binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); Wnt-protein binding (ortholog); INVOLVED IN astrocyte development; bone mineralization; macrophage migration; PARTICIPATES IN Wnt signaling, non-canonical pathway; ASSOCIAT ED WITH autosomal dominant Robinow syndrome 1 (ortholog); autosomal recessive Robinow syndrome (ortholog); brachydactyly (ortholog); FOUND IN cell surface; dendrite; glutamatergic synapse; INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; atrazine | 17 | 12124749 | 12300044 | Rat | 167 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313207 | ROR2 | receptor tyrosine kinase like orphan receptor 2 | The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008] | 9 | 91722601 | 91950228 | Human | 444 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1313208 | Ror2 | receptor tyrosine kinase-like orphan receptor 2 | Enables Wnt-protein binding activity; frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in positive regulation of DNA-templated transcription and positive regulation of canonical Wnt signaling pathway. Acts upstream of or within several processe s, including cartilage development; cell surface receptor signaling pathway; and embryonic morphogenesis. Predicted to be located in several cellular components, including cell surface; microtubule; and neuronal cell body. Predicted to be part of receptor complex. Predicted to be active in several cellular components, including axon; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study autosomal recessive Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like orphan receptor 2). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 53263353 | 53440160 | Mouse | 361 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8872143 | Ror2 | receptor tyrosine kinase like orphan receptor 2 | ENCODES a protein that exhibits frizzled binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); Wnt-protein binding (ortholog); INVOLVED IN astrocyte development (ortholog); BMP signaling pathway (ortholog); bone mineralization (ortholog); PARTICIPATES IN Wnt signalin g, non-canonical pathway; ASSOCIATED WITH autosomal dominant Robinow syndrome 1 (ortholog); autosomal recessive Robinow syndrome (ortholog); brachydactyly (ortholog); FOUND IN cell surface (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | NW_004955515 | 313612 | 554751 | Chinchilla | 68 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11850463 | ROR2 | receptor tyrosine kinase like orphan receptor 2 | ENCODES a protein that exhibits frizzled binding (ortholog); INVOLVED IN astrocyte development (ortholog); BMP signaling pathway (ortholog); bone mineralization (ortholog); PARTICIPATES IN Wnt signaling, non-canonical pathway; ASSOCIATED WITH autosomal dominant Robinow syndrome 1 (ortholog); autosom al recessive Robinow syndrome (ortholog); brachydactyly (ortholog); FOUND IN cell surface (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | 9 | 62782183 | 63005626 | Bonobo | 81 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12285165 | ROR2 | receptor tyrosine kinase like orphan receptor 2 | ENCODES a protein that exhibits frizzled binding (ortholog); INVOLVED IN astrocyte development (ortholog); BMP signaling pathway (ortholog); bone mineralization (ortholog); PARTICIPATES IN Wnt signaling, non-canonical pathway; ASSOCIATED WITH autosomal dominant Robinow syndrome 1 (ortholog); autosom al recessive Robinow syndrome (ortholog); brachydactyly (ortholog); FOUND IN cell surface (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | 1 | 95209122 | 95280956 | Dog | 80 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12679716 | Ror2 | receptor tyrosine kinase like orphan receptor 2 | ENCODES a protein that exhibits frizzled binding (ortholog); INVOLVED IN astrocyte development (ortholog); BMP signaling pathway (ortholog); bone mineralization (ortholog); PARTICIPATES IN Wnt signaling, non-canonical pathway; ASSOCIATED WITH autosomal dominant Robinow syndrome 1 (ortholog); autosom al recessive Robinow syndrome (ortholog); brachydactyly (ortholog); FOUND IN cell surface (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | NW_004936796 | 630307 | 675157 | Squirrel | 80 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 20866331 | ROR2 | receptor tyrosine kinase like orphan receptor 2 | ENCODES a protein that exhibits ATP binding (inferred); coreceptor activity (inferred); kinase activity (inferred); INVOLVED IN cell surface receptor protein tyrosine kinase signaling pathway (inferred); positive regulation of cell migration (inferred); signal transduction (inferred); FOUND IN membr ane (inferred); plasma membrane (inferred); receptor complex (inferred) | | | | Green Monkey | 18 | symbol | gene, protein-coding |
| 155239636 | ror2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18368220 | ROR2 | receptor tyrosine kinase like orphan receptor 2 | ENCODES a protein that exhibits frizzled binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); Wnt-protein binding (ortholog); INVOLVED IN astrocyte development (ortholog); BMP signaling pathway (ortholog); bone mineralization (ortholog); PARTICIPATES IN Wnt signalin g, non-canonical pathway; ASSOCIATED WITH autosomal dominant Robinow syndrome 1 (ortholog); autosomal recessive Robinow syndrome (ortholog); brachydactyly (ortholog); FOUND IN cell surface (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | | | | Green Monkey | 68 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18912084 | Ror2 | receptor tyrosine kinase like orphan receptor 2 | ENCODES a protein that exhibits frizzled binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN astrocyte development (ortholog); BMP signaling pathway (ortholog); bone mineralization (ortholog); PARTICIPATES IN Wnt signaling, non-canonical pathway; ASSOCI ATED WITH autosomal dominant Robinow syndrome 1 (ortholog); autosomal recessive Robinow syndrome (ortholog); brachydactyly (ortholog); FOUND IN cell surface (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | | | | Naked Mole-Rat | 81 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625944149 | Ror2 | receptor tyrosine kinase like orphan receptor 2 | ENCODES a protein that exhibits frizzled binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); Wnt-protein binding (ortholog); INVOLVED IN astrocyte development (ortholog); BMP signaling pathway (ortholog); bone mineralization (ortholog); PARTICIPATES IN Wnt signalin g, non-canonical pathway; ASSOCIATED WITH autosomal dominant Robinow syndrome 1 (ortholog); autosomal recessive Robinow syndrome (ortholog); brachydactyly (ortholog); FOUND IN cell surface (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 68 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14106292 | ROR2 | receptor tyrosine kinase like orphan receptor 2 | ENCODES a protein that exhibits frizzled binding (ortholog); INVOLVED IN astrocyte development (ortholog); BMP signaling pathway (ortholog); bone mineralization (ortholog); PARTICIPATES IN Wnt signaling, non-canonical pathway; ASSOCIATED WITH autosomal dominant Robinow syndrome 1 (ortholog); autosom al recessive Robinow syndrome (ortholog); brachydactyly (ortholog); FOUND IN cell surface (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | | | | Pig | 80 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155248821 | ror2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155248156 | ror2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1318175 | RORA | RAR related orphan receptor A | The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nu cleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014] | 15 | 60488284 | 61229302 | Human | 354 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1318176 | Rora | RAR-related orphan receptor alpha | The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nu cleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014] | 9 | 68560627 | 69295528 | Mouse | 496 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |