Ror2 (receptor tyrosine kinase like orphan receptor 2) - Rat Genome Database

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Gene: Ror2 (receptor tyrosine kinase like orphan receptor 2) Chinchilla lanigera
Analyze
Symbol: Ror2
Name: receptor tyrosine kinase like orphan receptor 2
RGD ID: 8872143
Description: ENCODES a protein that exhibits frizzled binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); Wnt-protein binding (ortholog); INVOLVED IN astrocyte development (ortholog); BMP signaling pathway (ortholog); bone mineralization (ortholog); PARTICIPATES IN Wnt signaling, non-canonical pathway; ASSOCIATED WITH 3-methylglutaconic aciduria type 1 (ortholog); autosomal dominant Robinow syndrome 1 (ortholog); autosomal recessive Robinow syndrome (ortholog); FOUND IN cell surface (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: receptor tyrosine kinase-like orphan receptor 2; tyrosine-protein kinase transmembrane receptor ROR2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955515313,604 - 553,774 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955515313,612 - 554,751 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ror2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955515313,604 - 553,774 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955515313,612 - 554,751 (+)NCBIChiLan1.0ChiLan1.0
ROR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38991,722,601 - 91,950,228 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl991,563,091 - 91,950,228 (-)EnsemblGRCh38hg38GRCh38
GRCh37994,484,883 - 94,712,510 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36993,524,705 - 93,752,265 (-)NCBINCBI36Build 36hg18NCBI36
Build 34991,564,438 - 91,791,999NCBI
Celera964,921,783 - 65,148,752 (-)NCBICelera
Cytogenetic Map9q22.31NCBI
HuRef964,163,034 - 64,390,111 (-)NCBIHuRef
CHM1_1994,631,872 - 94,858,883 (-)NCBICHM1_1
T2T-CHM13v2.09103,889,331 - 104,116,677 (-)NCBIT2T-CHM13v2.0
Ror2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391353,263,353 - 53,440,160 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1353,263,348 - 53,440,160 (-)EnsemblGRCm39 Ensembl
GRCm381353,109,317 - 53,286,124 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1353,109,312 - 53,286,124 (-)EnsemblGRCm38mm10GRCm38
MGSCv371353,204,686 - 53,381,478 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361353,121,749 - 53,293,643 (-)NCBIMGSCv36mm8
Celera1354,186,098 - 54,362,690 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1327.68NCBI
Ror2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81712,124,749 - 12,300,044 (+)NCBIGRCr8
mRatBN7.21711,972,830 - 12,148,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1711,972,830 - 12,148,152 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1711,902,485 - 12,082,513 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01713,505,264 - 13,680,160 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01711,822,226 - 11,997,115 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01711,953,552 - 12,134,386 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1711,953,552 - 12,134,386 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01714,049,344 - 14,228,982 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41717,735,999 - 17,917,032 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11717,736,906 - 17,919,811 (-)NCBI
Celera1711,736,765 - 11,913,446 (+)NCBICelera
Cytogenetic Map17p14NCBI
ROR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21147,544,807 - 47,768,359 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1947,547,221 - 47,770,508 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0962,782,183 - 63,005,626 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1990,879,826 - 90,939,834 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl990,851,983 - 90,965,084 (-)Ensemblpanpan1.1panPan2
ROR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1195,209,122 - 95,280,956 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl195,088,745 - 95,280,151 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha195,543,539 - 95,729,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0195,696,378 - 95,881,728 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl195,696,095 - 95,881,726 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1195,323,082 - 95,508,191 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0195,049,721 - 95,234,616 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0195,808,860 - 95,994,257 (+)NCBIUU_Cfam_GSD_1.0
Ror2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494413,309,541 - 13,354,707 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936796630,756 - 674,279 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936796630,307 - 675,157 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ROR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl142,804,061 - 3,035,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1142,803,840 - 3,035,384 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2143,602,862 - 3,834,887 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ROR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112102,172,288 - 102,397,297 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603890,423,503 - 90,650,327 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ror2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624868479,290 - 731,650 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624868479,303 - 732,723 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000002663   ⟹   ENSCLAP00000002609
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955515313,604 - 553,774 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000002664   ⟹   ENSCLAP00000002610
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955515495,806 - 553,774 (+)Ensembl
RefSeq Acc Id: XM_005408865   ⟹   XP_005408922
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955515313,612 - 554,751 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005408866   ⟹   XP_005408923
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955515495,844 - 554,751 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005408922 (Get FASTA)   NCBI Sequence Viewer  
  XP_005408923 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000002609
  ENSCLAP00000002609.1
  ENSCLAP00000002610
  ENSCLAP00000002610.1
Reference Protein Sequences
RefSeq Acc Id: XP_005408922   ⟸   XM_005408865
- Peptide Label: isoform X1
- UniProtKB: A0A8C2URE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005408923   ⟸   XM_005408866
- Peptide Label: isoform X2
- UniProtKB: A0A8C2ULE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000002610   ⟸   ENSCLAT00000002664
RefSeq Acc Id: ENSCLAP00000002609   ⟸   ENSCLAT00000002663
Protein Domains
FZ   Ig-like   Kringle   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001886 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000002663 ENTREZGENE
  ENSCLAT00000002663.1 UniProtKB/TrEMBL
  ENSCLAT00000002664 ENTREZGENE
  ENSCLAT00000002664.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Frizzled_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
  Kringle_CS UniProtKB/TrEMBL
  Kringle_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_rcpt_ROR UniProtKB/TrEMBL
NCBI Gene Ror2 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR2 UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PIRSF TyrPK_TMrec_ROR UniProtKB/TrEMBL
PRINTS KRINGLE UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00130 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57440 UniProtKB/TrEMBL
UniProt A0A8C2ULE0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2URE5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Ror2  receptor tyrosine kinase like orphan receptor 2    receptor tyrosine kinase-like orphan receptor 2  Symbol and/or name change 5135510 APPROVED